The role of polycaprolactone-triol (PCL-T) in biomedical applications: A state-of-the-art review

Abrisham, Mahbod; Noroozi, Mina; Panahi‐Sarmad, Mahyar; Arjmand, Mohammad; Goodarzi, Vahabodin; Shakeri, Yasaman; Golbaten-Mofrad, Hooman; Dehghan, Parham; Sahzabi, Alireza Seyfi; Sadri, Mahdi; Uzun, Lokman

doi:10.1016/j.eurpolymj.2020.109701

Cited by 65 publications

(26 citation statements)

References 62 publications

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“…Similar to PLA, the intrinsic hydrophobicity of PCL does not favor the osteoblastic adhesion or proliferation, further hindering bone‐to‐implant integration. To address this issue, several modification strategies, including polymer blending, 73 plasma treatment, 74 chemical treatment, 75 protein deposition (e.g., collagen), 76 and heat treatment, 77 have been implemented to alter the surface properties, degradation behaviors, and bioactivity of PCL‐based biomaterials. Wong et al 77 fabricated a modified PCL coating on AZ91 Mg alloy by a thermal approach.…”

Section: Polymeric Coatings On Mg‐based Biomaterialsmentioning

confidence: 99%

Polymer coatings on magnesium‐based implants for orthopedic applications

Zhu

Liu

Ngai

2021

Journal of Polymer Science

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Nowadays, the need for bio‐implants, which can gradually degrade after fulfilling the therapeutic tasks is continuously increasing. Under such situation, magnesium (Mg) and its alloys have been proposed and intensively studied as the new‐generation medical implants due to their favorable biodegradability and biocompatibility. However, their swift corrosion in physiological environments can always cause an early fracture and further the surgical failure, greatly hindering their broad applications. Therefore, great efforts have been made to alter the degradation behaviors of Mg‐based implants. Biodegradable polymeric surface coatings have been revealed to be a straightforward and effective strategy for retarding the fast degradation and improving the bioactivity of Mg and its alloys. This article reviews the recent progress of polymer‐based coatings on Mg substrates, regarding the coating strategies, coating properties, and their performance in corrosive protection and biocompatibility promotion via in vitro as well as some in vivo models. The specific pros and cons of different polymeric coatings are also discussed. Finally, we put forward some perspectives on the future direction of polymeric coatings on biomedical Mg‐based implants to better adapt to clinical trials.

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Section: Polymeric Coatings On Mg‐based Biomaterialsmentioning

confidence: 99%

Polymer coatings on magnesium‐based implants for orthopedic applications

Zhu

Liu

Ngai

2021

Journal of Polymer Science

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“…[19][20][21][22] Among them, PCL can be considered as a suitable nominee for its pharmaceutical and biomedical applications due to its exhibition biocompatibility, biodegradability, and tremendous toughness. [23][24][25] Blending the PLA and PCL provides an amalgamation of these preferred properties, provoking their blend to be suitable for diverse applications such as packaging, tissue engineering, and cardiovascular applications. [26][27][28][29] Also, investigating the performance of PLA/PCL blend in the presence of various nanoparticles and its influence on the microstructure as the third component has been recently in the center of attention of researchers.…”

Section: Introductionmentioning

confidence: 99%

Investigating the hydrolytic degradation of PLA/PCL/ZnO nanocomposites by using viscoelastic models

Dadashi

Babaei

Abdolrasouli

2022

Polymer Engineering & Sci

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“…The addition of sodium alginate was performed to form films with good mechanical resistance, cohesiveness and stiffness [ 30 ], while the presence of plasticizer-like glycerin is necessary to increase the elasticity and flexibility of the film [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Formulation, Characterization and Optimization of β–Glucan and Pomegranate Juice Based Films for Its Potential in Diabetes

Avramia

Amariei

2022

Nutrients

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The aim of this study was to develop films based on β–glucans in association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition. Initially, a Box-Behnken design was generated by varying the level of β–glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL) for development of films. Subsequently, glycerin was added as 25% of the total dry matter. The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color. The water activity profile and FT–IR analysis were performed in all tests. The model was used to determine the optimal experimental values considering that the optimal film will make a sustained contribution to diabetes. The optimal values of the film sample made of β–glucans, sodium alginate, pomegranate juice and glycerin make it befitting for packaging dry powdered pharmaceuticals. Finally, antimicrobial activity against Gram-negative and Gram-positive bacteria, UV barrier properties and microcrack and pore detections through SEM were also investigated for the optimal film sample.

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The role of polycaprolactone-triol (PCL-T) in biomedical applications: A state-of-the-art review

Cited by 65 publications

References 62 publications

Polymer coatings on magnesium‐based implants for orthopedic applications

Polymer coatings on magnesium‐based implants for orthopedic applications

Investigating the hydrolytic degradation of PLA/PCL/ZnO nanocomposites by using viscoelastic models

Formulation, Characterization and Optimization of β–Glucan and Pomegranate Juice Based Films for Its Potential in Diabetes

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