The Role of PMN-Leukocyte Lysosomes in Tissue Injury, Inflammation and Hypersensitivity

Movat, Henry Z.; Uriuhara, T.; Takeuchi, Y.; Macmorine, D. R. L.

doi:10.1159/000230406

Cited by 12 publications

(1 citation statement)

References 19 publications

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“…Furthermore, the PMNLs phagocytose the Ag-Ab complexes and ultimately undergo degranulation. Degranulation and eventual necrosis of PMNLs may have significant effects in tissue destruction since the PMNL lysosomal granules contain numerous proteolytic enzymes and chemical mediators of inflammation (Cochrane 1967, Movat et al 1971, Janoff 1972, Cochrane & Janoff 1974, Goldstein 1976, Taichman & McArthur 1976. Thus the combination of complement activation and PMNL lysosomal enzyme release are considered to be possible detrimental side effects of the normal host defense mechanism in periodontal disease.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural studies of infalmmation induced in rats by injection of antigen‐antibody precipitates

Garant

1979

J of Periodontal Research

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Single intramucosal injectins of ferritin‐antiferritin into the palate adjacent to the 1st molar produced a dense neutrophil infiltration within perivscular tissue adjacent to the palatal bone. Neutrophil degranulatin related to the phagocytosisi of antigen‐antibody (Ag‐Ab) precipitates occurred during the 1st 24 hours post injection. Rapidly developing bone damage was characterized by periosteal disruption, osteoblast and osteocyte necrosis and occasional swquestration of necrotic bone. Cytoplasmic changes such as dilated endowere observed inosteoblasts within 2 hrs of Ag‐Ab injection. Wound healing with regeneraionof periosteal tissue at the margins of the lesion was observed to begin at 4 days post injection. New bone was formed directly over the older necrotic bone without any intervening bone resorption. Extracellular matrix vesicles were observed adjacent ot newly differentiated bone cells.

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