The Role of Platelets in Cancer-Related Bleeding Risk: A Systematic Review

Larsen, Julie Brogaard; Højbjerg, Johanne Andersen; Hvas, Anne‐Mette

doi:10.1055/s-0039-3402429

Cited by 13 publications

(17 citation statements)

References 147 publications

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“…The quality assessment tool of The National Heart, Lung, and Blood Institute for observational cohort and cross sectional studies statement was used to study the extent of bias in the studies ( Table 4 ) (National Heart, 2018 ). This tool has been used in previous reviews (Ismaiel et al, 2019 ; López-Soto et al, 2019 ; Allevi et al, 2020 ; Kinshella et al, 2020 ; Larsen et al, 2020 ; Tarrant et al, 2020 ; Tinitali et al, 2021 ). The studies included in the present review were evaluated using this instrument.…”

Section: Resultsmentioning

confidence: 99%

The Impact of Social Support and Pregnancy on Subjective Well-Being: A Systematic Review

et al. 2021

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Background: Subjective well-being (SWB) has a protective role in mental health maintenance and is prone to change during short stressful moments, such as pregnancy. Longstanding research suggests that social support (SS) from the partner and family members of pregnant women directly or indirectly acts as a buffer against negative mental outcomes. For happier pregnancies, it is important to understand how SS and pregnancy affect the SWB.Objective: This review aims to examine the extended association of being pregnant and SS on the SWB of pregnant women.Methods: A systematic review was conducted in PubMed, ScienceDirect, and Google Scholar. Articles published in peer-reviewed journals were included regardless of the year and if they had assessed the impact of at least one SWB or SS outcome among healthy pregnant women. The tools of the National Heart, Lung, and Blood Institute were used for quality assessment.Results: Thirty-four studies that assessed the domains of SWB measurements, such as happiness, quality of life (QoL), life satisfaction, positive and negative effects, and well-being, were included and its association with either pregnancy or SS was summarized. Variable results, such as life satisfaction, happiness, and mental component of QoL, were found to be high during pregnancy, but positive emotion and physical components of QoL had decreased. Almost universally, SS during pregnancy was found to have a positive association with all measurements of SWB.Conclusion: This study had found that, despite some arising trends, pregnancy itself does not necessarily have similar impacts on SWB across healthy pregnant women. However, SS had a significant effect on SWB.

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Section: Resultsmentioning

confidence: 99%

The Impact of Social Support and Pregnancy on Subjective Well-Being: A Systematic Review

et al. 2021

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“…Patient and institutional factors often affect decisions to adjust chemotherapy. Generally, chemotherapy is administered with caution at platelet counts < 100 × 10 9 /L, and the risk of spontaneous bleeding increases at platelet counts < 10 × 10 9 /L in hematologic malignancy patients 8 and potentially higher platelet thresholds < 20 × 10 9 /L in some solid tumor patients 12,13 . When maintaining the chemotherapy dose intensity is critical for response or survival, dose modifications are avoided, and when platelet counts fall below 10 × 10 9 /L or in cases of active bleeding, platelet transfusions are frequently utilized 8 .…”

Section: Introductionmentioning

confidence: 99%

The incidence of thrombocytopenia in adult patients receiving chemotherapy for solid tumors or hematologic malignancies

Shaw

Nielson

Park

et al. 2021

European J of Haematology

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Objectives To estimate the risk of thrombocytopenia in various cancers and chemotherapy regimens. Methods Structured patient‐level data from the Flatiron Health Electronic Health Record database were used to identify adult patients who received chemotherapy for a solid tumor or hematologic malignancy from 2012 to 2017. Three‐month cumulative incidence of thrombocytopenia was assessed based on platelet counts, overall and by grade of thrombocytopenia. Co‐occurrence of anemia, neutropenia, and leukopenia was evaluated. Results Of 15,521 patients with solid tumors, 13% had thrombocytopenia within 3 months (platelet count < 100 × 109/L); 4% had grade 3 (25 to < 50 × 109/L), and 2% grade 4 (<25 × 109/L) thrombocytopenia. Of 2537 patients with hematologic malignancies, 28% had any thrombocytopenia, 16% with grade 3, and 12% with grade 4. Among patients with thrombocytopenia, it occurred without another cytopenia in 18% of solid tumors and 7% of hematologic malignancies. Conclusions In a large, US‐representative sample of patients undergoing chemotherapy in clinical practice, thrombocytopenia incidence varied across tumor and regimen types. Despite recommendations to alter chemotherapy to avoid severe thrombocytopenia, 4% of patients with solid tumors and 16% with hematologic malignancies experienced grade 3 thrombocytopenia. Prediction and prevention of thrombocytopenia may help oncologists avoid dose modifications and their adverse effects on survival.

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Section: тромбоцитыunclassified

“…Связь между числом тромбоцитов и кровотечениями убедительно описана для пациентов с гематологическими злокачественными заболеваниями, и безопасные пороговые показатели для профилактических переливаний тромбоцитов установлены [110,111]. В противовес этому сведения, касающиеся пациентов с солидными опухолями, крайне ограничены, хотя известно, что риск возникновения кровотечений увеличивается при количестве тромбоцитов ≤10×10 9 /л [110]. Тесты вязкости и анализ функции тромбоцитов могут быть более точными, если оценивается число тромбоцитов для определения рисков развития кровотечения у онкологических больных [110,112], как было установлено для других групп пациентов [113,114].…”

Section: тромбоцитыunclassified

“…В противовес этому сведения, касающиеся пациентов с солидными опухолями, крайне ограничены, хотя известно, что риск возникновения кровотечений увеличивается при количестве тромбоцитов ≤10×10 9 /л [110]. Тесты вязкости и анализ функции тромбоцитов могут быть более точными, если оценивается число тромбоцитов для определения рисков развития кровотечения у онкологических больных [110,112], как было установлено для других групп пациентов [113,114]. Здесь также следует упомянуть, что сведения о профилактических переливаниях тромбоцитов являются недостаточно качественными для пациентов с тромбоцитопенией, вызванной химиотерапией, и пациентов с солидными опухолями, равно как и для пациентов с низким дооперационным числом тромбоцитов [111,115].…”

Section: тромбоцитыunclassified

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Patient blood management in oncology in the Russian Federation: resolution to improve oncology care.

et al. 2020

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The huge global burden of oncological diseases is growing and measures to counter this complex challenge are high on national health agendas. The Russian National Long-Term Oncology Strategy 2030 defines priorities, goals and directions in the fight against cancer. Italso contains action plans for more effective prevention, earlier and more specific diagnosis and more effective treatment options. Against this backdrop, experts now suggest to complement standard oncology treatment strategies by adding Patient Blood Management (PBM). For many clinical disciplines where a low blood count and considerable blood loss are commonly encountered, this bundle of care is the new standard. Based on clinical and scientific evidence, it aims to optimise medical and surgical patient outcomes by clinically managing and preserving a patients blood. The principles of this comprehensive concept can and must be transferred to oncology, thus offering value in improving cancer care and the efficacy of medical institutions. Accumulating evidence demonstrates that anaemia and iron deficiency, but also thrombocytopenia, blood loss and coagulopathy are independent risk factors for adverse patient outcomes including morbidity, mortality, reduced quality of life and prolonged average length of hospital stay in both surgical and medical patients. For the timely and effective detection and correction of these risk factors, an international network of multi-disciplinary clinicians and researchers has developed PBM. The rapidly growing body of evidence for PBM not only shows improved patient outcomes, but also reduced resource utilisation including the use of allogeneic blood components. The reduction of allogeneic blood transfusion further improves patient safety and outcomes, since transfusion is another independent risk factor for adverse outcomes. Supported by WHO endorsements and following the recommendations of an increasing number of state or national health authorities, PBM is about to become a new standard of care. However, even though the aforementioned risk factors are highly prevalent in oncology settings due to chemo-/radiotherapy and the pathology of the disease, the integration of PBM in standard oncology treatment pathways is lagging behind. Thus, and in support of the Russian National Long-Term Oncology Strategy 2030 to improve quality of oncological care, with the support of the National Association of Specialists in PBM (NASPBM), the PBM Oncology Working Group of the Russian Federation was created, consisting of national and international experts in oncology and PBM. On July 9, 2020, the Working Group met to discuss the rationale for PBM in oncology and to assess the need to implement PBM in Russian oncology care. As a result, the Group recommended to include PBM as an integral part of standard oncology treatment pathways, delineated the action required from facilitating stakeholders in the Russian Federation, determined a roadmap for implementation and developed a national resolution as a call to action on the matter. Presented herein, this resolution acknowledges the global and local impetus to reduce cancer mortality, and the rationale for PBM interventions to improve patient outcomes and alleviate the social and economic burden of cancer on the healthcare system.

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The Role of Platelets in Cancer-Related Bleeding Risk: A Systematic Review

Cited by 13 publications

References 147 publications

The Impact of Social Support and Pregnancy on Subjective Well-Being: A Systematic Review

The Impact of Social Support and Pregnancy on Subjective Well-Being: A Systematic Review

The incidence of thrombocytopenia in adult patients receiving chemotherapy for solid tumors or hematologic malignancies

Patient blood management in oncology in the Russian Federation: resolution to improve oncology care.

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