The Role of Platelet Indices in Predicting Short-Term Mortality in Elderly Patients with Pulmonary Embolism

Özdemir, Serdar; Algın, Abdullah

doi:10.16899/jcm.988406

Cited by 8 publications

(5 citation statements)

References 19 publications

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“…Disseminated intravascular coagulation, immune mechanisms, and hypersplenism are some examples of mechanisms that could be mechanism of platelet reduction in malaria patients as sepsis and septic shock. 19,20 The transient increase in band cells observed in infection indicates a stronger stimulus for neutrophil production during the acute phase of infection. In the acute phase, premature release of neutrophils from the bone marrow occurs, resulting in an increased proportion of young-er, less well-differentiated neutrophils into the circulation.…”

Section: Discussionmentioning

confidence: 99%

The role of hematological parameters in differentiating Plasmodium falciparum and others – a study from Somalia

Özdemir¹,

Algın²,

Altunok³

et al. 2022

Eur J Clin Exp Med

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Introduction and aim. Accurate identification of Plasmodium species is important because of the differences in their treatment. We aimed to investigate the role of hematological and biochemical parameters in the differentiation of Plasmodium falciparum and other plasmodium species. Material and methods. This is a retrospective study. Patients admitted to the emergency department with signs and symptoms of malaria were included into the study. Patients with malaria were grouped as P. falciparum and others. Hematological parameters of two groups were compared by univariate and multivariate analysis. Statistical analysis was performed using the Jamovi. Results. A total of 107 patients were included in the study. According to univariant and multivariant analysis there was no difference in between two groups in the terms of blood urea nitrogen, aspartate aminotransferase, total bilirubin, hemoglobin, hematocrit, white blood cell count, platelet count, and mean platelet volume (in univariate analysis p values were 0.029, 0.011, 0.019, 0.171, 0.870, 0.307, 0.042, and 0.276, respectively and in multivariate analysis p values for blood urea nitrogen, aspartate aminotransferase, total bilirubin, hemoglobin, and platelet count were 0.100, 0.535, 0.328, and 0.213, respectively). Conclusion. The investigated hematological and biochemical parameters were found to be not valuable in predicting type of malaria. On the other hand, we recommend confirming the results of our study with larger samples and multicenter studies.

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Section: Discussionmentioning

confidence: 99%

The role of hematological parameters in differentiating Plasmodium falciparum and others – a study from Somalia

Özdemir¹,

Algın²,

Altunok³

et al. 2022

Eur J Clin Exp Med

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“…2 Patients with impaired hemodynamics due to pulmonary embolism may present with arterial hypotension and shock. 3 Deep vein thrombosis is an important cause of APE, and these patients may present with the complaint of leg swelling. Pulmonary embolism can be diagnosed incidentally in imaging tests performed for another reason without any complaints or findings, or at autopsy.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Symptoms and Signs in Geriatric Acute Pulmonary Embolism—An Analytical Study

Özdemir,

Özkan

2024

Ibnosina Journal of Medicine and Biomedical Sciences

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Objective The aim of this study was to evaluate the relationship between symptoms and short-term mortality in geriatric patients presenting to the emergency department with acute pulmonary embolism. Materials and Methods This retrospective cohort study was conducted to evaluate the data of geriatric patients admitted to the emergency department between September 01, 2022, and March 01, 2023. The study population comprised patients who presented with acute pulmonary embolism signs and symptoms. Demographic data, vital parameters, and symptoms were noted. Results Of the 176 patients included in the final analysis, 55 (31.2%) were female. The median of age was 76 (25th–75th percentile: 72–82.5) years. The most common symptoms were dyspnea (61.9%), fatigue (27.2%), and syncope (23.8%). There was no statistically significant difference between the survivor and nonsurvivor groups in terms of symptoms (p-values for dyspnea, syncope, chest pain, back pain, hemoptysis, extremity pain, and fatigue: 0.804, 0.765, 0.154, 0.543, 0.675, 0.342, and 0.943, respectively) (chi-squared test). Conclusion In patients presenting to the emergency department with acute pulmonary embolism, clinicians should not prioritize based on symptoms but should evaluate patients according to clinical severity scores.

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“…Platelets perform many functions other than hemostasis through biologically active molecules they store inside the cell. While bioactive mediators and adhesive proteins secreted from activated platelets provide interaction between platelets and regulate their interaction with other immune system cells 4 , 5 . Activated platelets facilitate the adhesion of neutrophils to the endothelium and regulate the pro-inflammatory functions of neutrophils.…”

Section: Introductionmentioning

confidence: 99%

Investigating the association between various platelet indices and different clinical sub-groups of severe malaria

Algın

Özdemir

Arslan³

et al. 2023

Mal. Med. J

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AimTo evaluate the ability of platelet count, mean platelet volume, platelet distribution width, and platelet mass index to predict the severity of malaria.Materials and MethodsThis study was conducted as a retrospective cohort study at a tertiary hospital in Somali. Patients grouped as severe and non-severe malaria. We compared groups in terms of platelet count, mean platelet volume, platelet distribution width, and platelet mass index.Results A total of 131 patients were included in the final analysis. Of the patients, 77 (58.7%) had non-severe malaria, and 54 (41.3%) had severe malaria. The multivariate analysis revealed that there was no significant difference between the groups in terms of platelet count, mean platelet volume, platelet distribution width, and platelet mass index (p: 0.183, 0.323, 0.204, and 0.139, respectively). In the receiver operating characteristic analysis, the area under the curve values for platelet count, mean platelet volume, platelet distribution width, and platelet mass index were 0.699, 0.619, 0.504, and 0.675, respectively.ConclusionOf the platelet indices, platelet count, mean platelet volume, platelet distribution width, and platelet mass index were not clinically significant markers that could be used to predict the severity of malaria.

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The Role of Platelet Indices in Predicting Short-Term Mortality in Elderly Patients with Pulmonary Embolism

Cited by 8 publications

References 19 publications

The role of hematological parameters in differentiating Plasmodium falciparum and others – a study from Somalia

The role of hematological parameters in differentiating Plasmodium falciparum and others – a study from Somalia

Prognostic Value of Symptoms and Signs in Geriatric Acute Pulmonary Embolism—An Analytical Study

Investigating the association between various platelet indices and different clinical sub-groups of severe malaria

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