The role of plasma IDO activity as a diagnostic marker of patients with colorectal cancer

Abstract

High levels of indoleamine 2,3-dioxygenase (IDO) are involved in tumour escape mechanisms. The aim of this study is the evaluation of L-kynurenine of plasma as marker of diagnostic and prognostic in patients with colorectal cancer. The study included 78 patients with colorectal cancer, of whom 15 % were in stage I/II, 30 % in stage III, and 55 % in stage IV, and was compared with a control group of 70 healthy subjects. The receiver operating characteristic (ROC) curve analysis showed an area under the curve of 0.917, with a specificity of 100 % and with a sensitivity to detect cancer of the colon of 85.2 %, taking 1.83 μM as a cut-off point. The overall survival analysis also indicated that patients with low levels of L-kynurenine in plasma increased survival rate after 45 months of follow-up (P = 0.032). These results show that the plasma levels of L-kynurenine could be a good biomarker to differentiate individuals with colorectal cancer from healthy individuals.

Expression and Prognostic Value of Indoleamine 2,3-dioxygenase in Pancreatic Cancer

“…This finding is consistent with recent reports on other tumors, such as colorectal cancer, ovarian cancer, hepatocellular carcinoma, and esophageal squamous cell cancer. [14192027] Although TNM staging is also a prognostic predictor for cancer patients, this factor did not exhibit statistically significant correlation with overall patient survival as detected through multivariate analysis in the present study. This observation might be explained mainly by the notion that the statistical results were limited by the low number of cases and short observation period.…”

“…Other studies demonstrated that high levels of IDO were present in the advanced stages of ovarian carcinoma and colorectal cancer. [1920] Moreover, IDO expression was found in all invasive uterine cervical cancers, whereas noninvasive tumors presented a lower expression level. [2122] These findings suggest that IDO might enhance the proliferation, invasion, and metastatic abilities of cancer cells to represent a high degree of malignancy through various mechanisms.…”

Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer

“…These data suggest that Trp catabolism by the IDO1 activity is associated with the progression of CRC. Different physiological and pathological factors, such as pregnancy, organ transplants, autoimmune diseases, or viral infections, are known to affect serum or plasma levels of Kyn in CRC patients [34, 35]. The aforementioned explains the lack of any significant association between Kyn or Trp concentrations and clinicopathological parameters in the present study.…”

Celastrol Suppresses Tryptophan Catabolism in Human Colon Cancer Cells as Revealed by Metabolic Profiling and Targeted Metabolite Analysis

“…IDO expression is markedly increased in variety of cancers, including ovarian, colorectal, pancreatic cancers, and non-small-cell lung carcinoma, 27) and plasma IDO level can be used as the diagnostic indicator for colorectal cancer. [28][29][30][31] In this work, celestrol treatment caused obviously decreased Data were expressed as mean±S.D. (n=5).…”