The role of plant antimicrobial peptides (AMPs) in response to biotic and abiotic environmental factors

Kulaeva, Olga A.; Kliukova, Marina S.; Afonin, Alexey М.; Sulima, Anton S.; Zhukov, Vladimir A.; Тихонович, И. А.

doi:10.21638/spbu03.2020.205

Cited by 12 publications

(10 citation statements)

References 130 publications

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“…They provide a so-called “first defense line” against a variety of environmental stress factors, primarily of a biotic nature [ 4 , 5 , 6 ]. Plant defense peptides are divided into seven families according to their Cys motif [ 7 , 8 ]. Hairpin-like peptides (α-hairpinins) are one of the youngest structural families.…”

Section: Introductionmentioning

confidence: 99%

Rational Design of Plant Hairpin-like Peptide EcAMP1: Structural–Functional Correlations to Reveal Antibacterial and Antifungal Activity

2022

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Plant antimicrobial peptides from the α-hairpinins family (hairpin-like peptides) are known to possess a wide range of biological activities. However, less is known about the structural determinants of their antimicrobial activity. Here, we suggest that spatial structure as well as surface charge and hydrophobicity level contribute to the antimicrobial properties of α-hairpinin EcAMP1 from barnyard grass (Echinochloa cruss-galli) seeds. To examine the role of the peptide spatial structure, two truncated forms of EcAMP1 restricted by inner and outer cysteine pairs were synthesized. It was shown that both truncated forms of EcAMP1 lost their antibacterial activity. In addition, their antifungal activity became weaker. To review the contribution of surface charge and hydrophobicity, another two peptides were designed. One of them carried single amino acid substitution from tryptophan to alanine residue at the 20th position. The second one represented a truncated form of the native EcAMP1 lacking six C-terminal residues. But the α-helix was kept intact. It was shown that the antifungal activity of both modified peptides weakened. Thereby we can conclude that the secondary structural integrity, hydrophobic properties, and surface charge all play roles in the antimicrobial properties of α-hairpinins. In addition, the antibacterial activity of cereal α-hairpinins against Gram-positive bacteria was described for the first time. This study expands on the knowledge of structure–function interactions in antimicrobial α-hairpinins.

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Section: Introductionmentioning

confidence: 99%

Rational Design of Plant Hairpin-like Peptide EcAMP1: Structural–Functional Correlations to Reveal Antibacterial and Antifungal Activity

2022

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“…AMPs exhibit a broad spectrum of inhibitory efficacy against bacteria, fungi, and viruses [ 57 , 58 ] and play crucial roles as innate immune effectors across diverse species, including humans, animals, and crops. AMPs serve as the first line of defense against foreign invaders [ 59 , 60 ]. AMPs possess diverse biological functions [ 61 ].…”

Section: B Laterosporus Antimicrobial Peptidesmentioning

confidence: 99%

Brevibacillus laterosporus: A Probiotic with Important Applications in Crop and Animal Production

Liu,

Zai,

Weng

et al. 2024

Microorganisms

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Brevibacillus laterosporus (B. laterosporus) is widely distributed in nature and demonstrates significant potential for applications in biological control, environmental protection, agricultural production, and clinical medicine. This review provides a comprehensive overview of the applications of B. laterosporus in crop cultivation and animal feeding, as well as an examination of the antimicrobial peptides produced by B. laterosporus and their antibacterial mechanisms. B. laterosporus enhances crop cultivation by secreting hydrolases to improve nutrient absorption capabilities, synthesizing hormones to promote crop growth, and producing proteins to inhibit the reproduction of harmful organisms. B. laterosporus has been used to improve animal production by regulating the structure of the intestinal microbiota and inhibiting the growth of pathogenic bacteria through the secretion of various antimicrobial peptides. The bactericidal activity of Brevilaterins secreted by B. laterosporus is attributed to their ability to bind to lipopolysaccharide/lipid II molecules on the cell membrane, thereby altering permeability. Brevilaterins also inhibit bacterial reproduction by affecting relevant gene pathways in the cell membranes of pathogenic bacteria. These pathways include ATP synthesis, peptidoglycan biosynthesis, membrane transport, and cellular metabolism. In conclusion, B. laterosporus exhibits substantial potential as a probiotic activity in crop and animal production. However, applications of B. laterosporus in animal production could be improved, necessitating further research to elucidate the underlying probiotic mechanisms.

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“…Antimicrobial peptides (AMPs) have raised an upsurge of research interest since their first report in the 1980s (Zasloff, 2002). In plants, AMPs are the most common and prominent defense barriers that help plants to deal with pathogenic assaults (Olga et al., 2020) and are part of the innate immune system with a broad spectrum of antimicrobial activity against the invasion of exogenous fungi, bacteria, and viruses. AMPs interact with the phospholipid in the cell membrane instead of a specific receptor, and resistance against AMPs in pathogens can hardly be induced.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial peptides in Dendrobium officinale: Genomic parameters, peptide structures, and gene expression patterns

et al. 2023

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A weak codon usage bias was found in Dendrobium catenatum (D. officiale) antimicrobial peptides (AMPs), after the analysis of relative synonymous codon usage, GC contents, and the effective number of codons. The codon usage preference was mainly influenced by natural selection pressure. The self‐optimized prediction method and SWISS‐MODEL were applied for peptide structural and domain analyses, and some typical antimicrobial domains were found in D. officinale AMP amino sequences, such as knot1 domain, gibberellins‐stimulated domain, cupin_1 domain, defensin_like domain, and SLR1‐BP (S locus‐related glycoprotein 1 binding pollen coat protein) domain. To investigate the AMPs gene expression pattern, abiotic stresses, such as salt stress, drought stress, salicylic acid (SA), and methyl jasmonate (JA), were applied and the gene expression levels were detected by the real‐time fluorescent quantitative polymerase chain reaction. Results showed that, even though the basic AMPs gene expressions were low, some AMPs can still be induced by salt dress, while the drought dress did not show the same impact. The SA and JA signaling pathways might be involved in most of the AMPs expressions. The natural selection of the D. officinale AMPs and thus forming diverse types of AMPs enhanced the plant's innate immunity and disease resistance capability, which would lead to a better understanding of the molecular mechanism for D. officinale adapting to the environment. The finding that salt stress, SA, and JA signaling pathways can induce AMP expression lays a foundation for the further development and functional verification of D. officinale AMPs.

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The role of plant antimicrobial peptides (AMPs) in response to biotic and abiotic environmental factors

Cited by 12 publications

References 130 publications

Rational Design of Plant Hairpin-like Peptide EcAMP1: Structural–Functional Correlations to Reveal Antibacterial and Antifungal Activity

Rational Design of Plant Hairpin-like Peptide EcAMP1: Structural–Functional Correlations to Reveal Antibacterial and Antifungal Activity

Brevibacillus laterosporus: A Probiotic with Important Applications in Crop and Animal Production

Antimicrobial peptides in Dendrobium officinale: Genomic parameters, peptide structures, and gene expression patterns

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