The Role of Placental Membrane Allografts in the Surgical Treatment of Tendinopathies

Ang, Joel; Liou, Chih-Kang David; Schneider, Harry P.

doi:10.1016/j.cpm.2018.02.004

Cited by 12 publications

(7 citation statements)

References 28 publications

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“…However, the vCUT is thicker than placental membrane and can be easily manipulated and sutured at the surgical site. [27][28][29][30][31] In a rabbit model, vCUT was shown to prevent the development of postoperative adhesions and support the natural wound healing process. 26 Clinical case studies have reported positive outcomes with the use of vCUT in the surgical repair of tendons, fistulas, and limb salvage.…”

Section: Discussionmentioning

confidence: 99%

“…26 Clinical case studies have reported positive outcomes with the use of vCUT in the surgical repair of tendons, fistulas, and limb salvage. [27][28][29][30][31] To date, no CVOCA and vCUTrelated adverse events have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Surgical implantation of vCUT in animals and patients led to the reduction of inflammation and prevention of postoperative adhesions, correlating with less pain and faster postoperative recovery. [26][27][28][29][30][31] No adverse reactions have been reported for the CVOCA and vCUT.…”

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confidence: 99%

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Temporomandibular Joint Discectomy Followed by Disc Replacement Using Viable Osteochondral and Umbilical Cord Allografts Results in Improved Patient Outcomes

Connelly

Silva

Gupta

et al. 2020

Journal of Oral and Maxillofacial Surgery

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The ideal surgical solution to reconstruct the temporomandibular joint (TMJ) disc after it has been removed has remained elusive. The major obstacle has been identifying a durable biocompatible material that will provide for restoration of TMJ function. The present study evaluated the outcomes of the interpositional implantation of a cryopreserved viable osteochondral allograft (CVOCA) combined with a viable cryopreserved umbilical cord tissue (vCUT) allograft after TMJ discectomy in patients with internal derangement and/or degenerative joint disease (DJD). Patients and Methods: We implemented a retrospective case series study and enrolled patients with DJD or disc displacement diagnosed using the Diagnostic Criteria of Temporomandibular Disorders, who had undergone interpositional CVOCA and vCUT implantation after TMJ discectomy. The primary outcome variable was pain, measured using a visual analog scale (VAS). The secondary outcomes variables included maximal incisal opening (MIO) and Glasgow Benefit Inventory (GBI) general subscale scores. The primary analysis compared the preoperative measures with those at the last follow-up visit. Descriptive and analytic statistics were computed to summarize the sample's characteristics and assess the pre-and postoperative differences. Results: The study sample included 9 patients with a mean age of 36 years, and 44% were men. The VAS scores had decreased significantly from 9.0 AE 2.0 to 3.0 AE 3.0 postoperatively (P = .001). The MIO had increased from 31 AE 5 to 36 AE 5 mm (P = .178). The average GBI general subscale score of 13 AE 46 for the 9 patients showed a trend toward improved quality of life and patient satisfaction with the surgery. The median postoperative follow-up at the time of our report was 15 months (interquartile range, 10; range, 2 to 27) without treatment-related complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Temporomandibular Joint Discectomy Followed by Disc Replacement Using Viable Osteochondral and Umbilical Cord Allografts Results in Improved Patient Outcomes

Connelly

Silva

Gupta

et al. 2020

Journal of Oral and Maxillofacial Surgery

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“…Furthermore, the inhibitory effect on both proliferation and migration of fibroblast, responsible for adhesion formation, is a result of the intrinsic negative charge of HA [ 11 ]. Also, positive clinical outcomes of vCUT's surgical use indicate that the tissue allograft has anti-inflammatory properties and supports tissue repair processes [ 19 , 21 ]. The components and properties of vCUT described above suggested its potential benefits for post-surgical adhesion prevention.…”

Section: Discussionmentioning

confidence: 99%

“…Advances in cryopreservation have allowed the development of viable cryopreserved umbilical cord tissue (vCUT), which retains all the characteristics of fresh tissue with the advantage of long-term storage. vCUT is an “off-the-shelf” point-of-care commercial placental tissue allograft that is currently being used clinically in the management of limb-salvage cases and tendon and fistula surgical repairs [ [19] , [20] , [21] ]. The ease of surgical application, in conjunction with the demonstrated inherent properties of vCUT, prompted this study to further evaluate the use of vCUT for the prevention of post-surgical adhesion in a rabbit abdominal adhesion model.…”

Section: Introductionmentioning

confidence: 99%

Viable cryopreserved umbilical tissue (vCUT) reduces post-operative adhesions in a rabbit abdominal adhesion model

Dhall

Coksaygan

Hoffman

et al. 2019

Bioactive Materials

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Post-operative adhesions, a common complication of surgery, cause pain, impair organ functionality, and often require additional surgical interventions. Control of inflammation, protection of injured tissue, and rapid tissue repair are critical for adhesion prevention. Adhesion barriers are biomaterials used to prevent adhesions by physical separation of opposing injured tissues. Current adhesion barriers have poor anti-inflammatory and tissue regenerative properties. Umbilical cord tissue (UT), a part of the placenta, is inherently soft, conforming, biocompatible, and biodegradable, with antimicrobial, anti-inflammatory, and antifibrotic properties, making it an attractive alternative to currently available adhesion barriers. While use of fresh tissue is preferable, availability and short storage time limit its clinical use. A viable cryopreserved UT (vCUT) “point of care” allograft has recently become available. vCUT retains the extracellular matrix, growth factors, and native viable cells with the added advantage of a long shelf life at −80 °C. In this study, vCUT's anti-adhesion property was evaluated in a rabbit abdominal adhesion model. The cecum was abraded on two opposing sides, and vCUT was sutured to the abdominal wall on the treatment side; whereas the contralateral side of the abdomen served as an internal untreated control. Gross and histological evaluation was performed at 7, 28, and 67 days post-surgery. No adhesions were detectable on the vCUT treated side at all time points. Histological scores for adhesion, inflammation, and fibrosis were lower on the vCUT treated side as compared to the control side. In conclusion, the data supports the use of vCUT as an adhesion barrier in surgical procedures.

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Placental membrane grafts for urethral replacement in a rabbit model: a pilot study

et al. 2019

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The Role of Placental Membrane Allografts in the Surgical Treatment of Tendinopathies

Cited by 12 publications

References 28 publications

Temporomandibular Joint Discectomy Followed by Disc Replacement Using Viable Osteochondral and Umbilical Cord Allografts Results in Improved Patient Outcomes

Temporomandibular Joint Discectomy Followed by Disc Replacement Using Viable Osteochondral and Umbilical Cord Allografts Results in Improved Patient Outcomes

Viable cryopreserved umbilical tissue (vCUT) reduces post-operative adhesions in a rabbit abdominal adhesion model

Placental membrane grafts for urethral replacement in a rabbit model: a pilot study

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