The role of Piwi nuclear localization in the differentiation and proliferation of germline stem cells

Yakushev, E. Y.; Mikhaleva, Elena A.; Abramov, Yuri; Zyrianova, Irina M.; Гвоздев, В. А.; Klenov, Mikhail S.

doi:10.1134/s0026893316040154

Cited by 6 publications

(1 citation statement)

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“…As observed in normal gametogenesis, CTAs promote immortalization, implantation, and migration that could correspond in carcinogenesis to transformation, invasion, and metastasis, respectively (Figure 1). In this ectopic context, reactivation of the PIWI-piRNA pathway could confer properties of proliferative germline stem cells to cancer cells [61][62][63][64][65][66][67][68].…”

Section: Mechanisms Of the Piwi-pirna Pathway Deregulation In Cancermentioning

confidence: 99%

Part 2: Deregulated Expressions of PIWI Proteins and piRNAs as New Candidate Biomarkers and Potential Therapeutic Tools in Cancer

Meseure¹,

Alsibai²

2020

Chromatin and Epigenetics

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Epigenetic abnormalities are early events in carcinogenesis and associate heterogeneity of DNA methylation, modifications of histones, and deregulation of noncoding RNAs. Aberrant expressions of PIWI proteins and piRNAs were recently observed in numerous subtypes of malignant tumors and were implicated in occurrence of most cancer hallmarks such as cell proliferation, genomic stability, apoptosis inhibition, invasion, and metastatic spread. However, this pathway is a new emerging research field, and further investigations are necessary to elucidate their oncogenic or tumor-suppressing status. Since the aberrant expression of this pathway may induce stemness, analysis of relationship between PIWI proteins, piRNAs, and cancer stem cells may open new avenues in cancer research. The objective of this review is to provide a broad overview of the emerging implication of PIWI proteins and piRNAs in carcinogenesis and their potential clinical interest as diagnostic and prognostic biomarkers and therapeutic tools.

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