The role of phospholipase D in Glut‐4 translocation

Huang, Ping; Frohman, Michael A.

doi:10.1002/dmrr.416

Cited by 6 publications

(2 citation statements)

References 84 publications

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“…A marked decrease of the amount of GLUT-2 in plasma membranes was found in the treated cells compared with the untreated ones. Translocation from an intracellular pool to the plasma membrane has been widely described for GLUT-1 and GLUT-4 [25,26] . Moreover, in hematopoeietic M07e cells, a role for KIT tyrosine kinase on glucose transport activation through GLUT-1 translocation, has been suggested [27] .…”

Section: Discussionmentioning

confidence: 99%

Imatinib Mesylate Inhibits Glucose Uptake in Gastrointestinal Stromal Tumor Cells by Downregulation of the Glucose Transporters Recruitment to the Plasma Membrane

Prenen¹,

Stefan²,

Landuyt³

et al. 2005

American J. of Biochemistry and Biotechnology

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Imatinib mesylate, the inhibitor of the KIT protein tyrosine kinase that is constitutively activated in Gastrointestinal Stromal Tumors (GISTs), has been established as the first highly effective drug in the treatment of patients with advanced GISTs. Recent studies suggest that changes in the glucose metabolism could be an additional mechanism of the anti-proliferative action of imatinib. The aim of this study was to investigate the effect on glucose flux and metabolism in a human GIST882 cell line after exposure to imatinib. Imatinib induced a concentration-dependent inhibition of cell proliferation in GIST882 cells (IC₅₀, 0.030 ± 0.006 µM). By ¹⁸F-FDG uptake measurements, after 24 h exposure to the drug at concentrations of 0.03 µM and 0.3 µM, the glucose uptake decreased by ~25% and ~95%, respectively. Moreover, after a 3-h treatment at the concentration of 0.3 µM of imatinib the decrease in glucose-uptake was already more than 50%. After 24-h of treatment with 0.3 µM imatinib, the measurements of the hexokinase and glucose-6-phosphate dehydrogenase activity revealed a 30% and 37% decrease, respectively. Western blotting disclosed mainly expression of glucose transporter GLUT-2 in GIST cells. Exposure of GIST cells to imatinib resulted in the decline of the GLUT-2 receptor recruitment to cell membrane, which paralleled with the elevated amount of the total KIT protein. These findings suggest that a rapid decline in glucose uptake following imatinib treatment in GIST cells is dependent on glucose transporter impaired anchorage to the plasma membrane, with the subsequent recruitment of KIT protein

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Section: Discussionmentioning

confidence: 99%

Imatinib Mesylate Inhibits Glucose Uptake in Gastrointestinal Stromal Tumor Cells by Downregulation of the Glucose Transporters Recruitment to the Plasma Membrane

Prenen¹,

Stefan²,

Landuyt³

et al. 2005

American J. of Biochemistry and Biotechnology

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“…PI3K activates phosphoinositide-dependent kinase and atypical protein kinase C, then participates in glucose uptake via GLUT [101] as well as glycogen synthesis [102]. PDK activates the downstream effectors GLUT4, mTOR, and phosphodiesterase 3B by activating Akt, which is closely associated with subsequent glucose uptake, protein synthesis, and lipid inhibition [103].…”

Section: Pi3k-akt Pathwaymentioning

confidence: 99%

Branched-Chain Amino Acids Metabolism and Their Roles in Retinopathy: From Relevance to Mechanism

Zhang

Xia

et al. 2023

Nutrients

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Retinopathy is one of the leading causes of irreversible blindness and vision loss worldwide. Imbalanced nutrients play important roles in the pathogenesis and pathophysiology of retinal diseases. Branched-Chain Amino Acids (BCAAs), as essential amino acids, perform a variety of biological functions, including protein synthesis, glucose metabolism, lipid metabolism, inflammation, and oxidative stress in metabolic tissues of diabetes and aging-related diseases. Recently, it has been shown that BCAAs are highly related to neuroprotection, oxidative stress, inflammatory and glutamate toxicity in the retina of retinopathy. Therefore, this review summarizes the alterations of BCAA levels in retinopathy, especially diabetic retinopathy and aging-related macular disease, and the genetics, functions, and mechanisms of BCAAs in the retina as well as other metabolic tissues for reference. All of these efforts aim to provide fundamental knowledge of BCAAs for further discoveries and research on retina health based on the sensing and signaling of essential amino acids.

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Current literature in diabetes

2004

Diabetes Metabolism Res

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 17 sections: 1 Books, Reviews & Symposia; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Prediction; 7 Prevention; 8 Intervention: a) General; b) Pharmacology; 9 Pathology: a) General; b) Cardiovascular; c) Neurological; d) Renal; 10 Endocrinology & Metabolism; 11 Nutrition; 12 Animal Studies; 13 Techniques. Within each section, articles are listed in alphabetical order with respect to author (6 Weeks journals ‐ Search completed at 5th May 2004)

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The role of phospholipase D in Glut‐4 translocation

Cited by 6 publications

References 84 publications

Imatinib Mesylate Inhibits Glucose Uptake in Gastrointestinal Stromal Tumor Cells by Downregulation of the Glucose Transporters Recruitment to the Plasma Membrane

Imatinib Mesylate Inhibits Glucose Uptake in Gastrointestinal Stromal Tumor Cells by Downregulation of the Glucose Transporters Recruitment to the Plasma Membrane

Branched-Chain Amino Acids Metabolism and Their Roles in Retinopathy: From Relevance to Mechanism

Current literature in diabetes

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