The role of phase I and II genetic polymorphisms, smoking, alcohol and cancer family history, in the risk of developing testicular cancer

Roco, Ángela; Lavanderos, Alejandra; Cayún, Juan P; Acevedo, Cristián; Celedón, Cesar; Rubilar, Juan Carlos; Sandoval, Carolina; Cerpa, Leslie C.; García‐Martín, Elena; Agúndez, José A. G.; Esguevillas, Gara; Amo, Gemma; Canepa, Angelo; Cerda, Berta de la; Peña, Karina; Cáceres, Dante; Varela, Nelson; Quiñones, Luis A.

doi:10.1097/fpc.0000000000000379

Cited by 10 publications

(3 citation statements)

References 40 publications

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“…Chile, Tonga, and Monaco had higher ASIR, ASPR, ASDR, and agestandardized DALYs than the other countries, particularly Chile. Previous research has also discovered a higher rate of TC in Chile, and some have found that speci c genetic loci may be to blame for the high incidence and prevalence in Chile [31,32]. Most countries with a high burden of TC are in the Central Europe, Southern Latin American and Western Europe regions, so there is a need to strengthen early prevention, early diagnosis and medical services in these regions and countries to reduce the disease burden caused by TC.…”

Section: Disease Burden Projectionsmentioning

confidence: 99%

The global, regional, and national testicular cancer burden and trends from 1990 to 2019: results from the Global Burden of Disease Study 2019

Huang,

Li,

Chen

et al. 2023

Preprint

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Background:To assess the disease burden of Testicular Cancer (TC) from 1990 to 2019. Methods:Global, regional and national age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR), age-standardized death rate (ASDR) and age-standardized disability-adjusted life years rate (DALYs) from 1990-2019 were used to analyze the disease burden of TC, combined with decomposition analyses and frontier analyses. Results: The global ADIR, ASPR, ASDR, and age-standardized DALYs in 2019 were 2.79 (2.36,3.33), 21.24 (17.59,25.94), 0.28 (0.26,0.31), and 14.24 (12.91,15.98), respectively. The burden of disease varied by region and country, with Central Europe and Southern Latin America having higher than expected levels. Chile, Tonga, and Monaco were among the countries with a higher disease burden. Decomposition analysis showed population growth as the main factor for changing age-standardized DALYs. Frontier analysis showed that age-standardized DALYs in different countries have much room for improvement, especially in Tonga and Kiribati. The global ADIR, ASPR, ASDR, and age-standardized DALYs are projected to be 3.13, 24.08, 0.29, and 15.01 by 2030. Conclusions: TC remains a global public problem. There are significant regional and national differences, and therefore different regions and countries should be targeted to improve the disease burden of TC.

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Section: Disease Burden Projectionsmentioning

confidence: 99%

The global, regional, and national testicular cancer burden and trends from 1990 to 2019: results from the Global Burden of Disease Study 2019

Huang,

Li,

Chen

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…Preoperative participant information was collected from the anesthesia information management system and electronic medical record (EMR), including demographics, history of smoking and drinking, surgical history, other morbidities and so on. Smoker was defined as the Brinkman’s index of tobacco addiction >400 (>20 packs of 20 cigarettes/year), and exposure 280 g or more per week was used as a cutoff value to classified exposure of alcohol [21]. All participants received a thorough physical examination, including checking for the presence of clubbing and liver palm, ascites, the number of spider angiomas, encephalopathy and dyspnea.…”

Section: Study Proceduresmentioning

confidence: 99%

Hepatopulmonary syndrome delays postoperative recovery and increases pulmonary complications after hepatectomy

Bai

Tang

et al. 2021

European Journal of Gastroenterology &Amp; Hepatology

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“…As reactive species may set an ambient for cancer onset and evolution, the redox status of still very young male individuals could be additionally characterized by perturbations due to reduced antioxidant activities of GSTO isoenzymes. Several polymorphisms in the GST omega class have been acknowledged as cancer-risk biomarkers [ 22 , 23 , 24 , 25 ], but, to the best of our knowledge, this is the first study investigating the association of GSTO1 polymorphic expression in relation to testicular tumorigenesis [ 31 , 32 , 33 , 34 , 35 ]. Therefore, the aim of this pilot study was to further define a unique redox profile by determining the individual, combined, haplotype, and cumulative effect of GSTO1 rs4925, GSTO2 rs156697, and GSTO2 rs2297235 genetic variants on the risk for testicular germ cell tumor development.…”

Section: Introductionmentioning

confidence: 99%

The Polymorphisms in GSTO Genes (GSTO1 rs4925, GSTO2 rs156697, and GSTO2 rs2297235) Affect the Risk for Testicular Germ Cell Tumor Development: A Pilot Study

Petrovic¹,

Simić

Djukić

et al. 2023

Life

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Members of the omega class of glutathione transferases (GSTs), GSTO1, and GSTO2, catalyze a range of reduction reactions as a part of the antioxidant defense system. Polymorphisms of genes encoding antioxidant proteins and the resultant altered redox profile have already been associated with the increased risk for testicular germ cell cancer (GCT) development. The aim of this pilot study was to assess the individual, combined, haplotype, and cumulative effect of GSTO1rs4925, GSTO2rs156697, and GSTO2rs2297235 polymorphisms with the risk for testicular GCT development, in 88 patients and 96 matched controls, through logistic regression models. We found that carriers of the GSTO1*C/A*C/C genotype exhibited an increased risk for testicular GCT development. Significant association with increased risk of testicular GCT was observed in carriers of GSTO2rs2297235*A/G*G/G genotype, and in carriers of combined GSTO2rs156697*A/G*G/G and GSTO2rs2297235*A/G*G/G genotypes. Haplotype H7 (GSTO1rs4925*C/GSTO2rs2297235*G/GSTO2rs156697*G) exhibited higher risk of testicular GCT, however, without significant association (p > 0.05). Finally, 51% of testicular GCT patients were the carriers of all three risk-associated genotypes, with 2.5-fold increased cumulative risk. In conclusion, the results of this pilot study suggest that GSTO polymorphisms might affect the protective antioxidant activity of GSTO isoenzymes, therefore predisposing susceptible individuals toward higher risk for testicular GCT development.

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The role of phase I and II genetic polymorphisms, smoking, alcohol and cancer family history, in the risk of developing testicular cancer

Cited by 10 publications

References 40 publications

The global, regional, and national testicular cancer burden and trends from 1990 to 2019: results from the Global Burden of Disease Study 2019

The global, regional, and national testicular cancer burden and trends from 1990 to 2019: results from the Global Burden of Disease Study 2019

Hepatopulmonary syndrome delays postoperative recovery and increases pulmonary complications after hepatectomy

The Polymorphisms in GSTO Genes (GSTO1 rs4925, GSTO2 rs156697, and GSTO2 rs2297235) Affect the Risk for Testicular Germ Cell Tumor Development: A Pilot Study

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