The role of pharmacotherapy in the treatment of endometriosis across the lifespan

Schwartz, Kaia; Llarena, Natalia C.; Rehmer, Jenna M.; Richards, Elliott G.

doi:10.1080/14656566.2020.1738386

Cited by 18 publications

(15 citation statements)

References 69 publications

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“…Esses dados de custos antes e após o início do tratamento medicamentoso demonstrou que, ao se fazer um diagnóstico correto, rápido e se iniciar o tratamento de forma adequada, os gastos desnecessários com grande número de exames e vários medicamentos para controle de sintomas e de dor diminuem consideravelmente 13 . Isso evidencia ainda mais a necessidade da conscientização da população para buscar figura 5: escala de percepção de gastos dentro do orçamento familiar.…”

Section: Resultsunclassified

Impacto do tratamento medicamentoso da endometriose nas questões profissionais, sexuais e econômicas das mulheres

Trindade¹,

Bianchin²,

Kluppel³

et al. 2021

SaudColetiv (Barueri)

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Objetivo: avaliar a melhora da qualidade de vida das mulheres com endometriose sob o tratamento medicamentoso e a demora no diagnóstico. Método: o estudo se deu por meio de inquérito on-line via plataforma GoogleForms®, dirigido à mulheres diagnosticadas com endometriose. Resultado: foram entrevistadas um total de 476 mulheres (entre 19 e 38 anos de idade) residentes na cidade de Joinville e Região, a grande maioria nos estágios I e II de endometriose. A entrevista levantou dados sobre tempo até diagnóstico, medicamentos e terapêuticas utilizados, graus de comprometimento profissional, vida sexual e impacto econômico antes e após diagnostico e tratamento. Conclusão: o diagnóstico e tratamento correto para a endometriose, amenizando a sintomatologia e gastos extras, auxiliam na redução dos impactos sociais, econômicos e profissionais na vida das mulheres com essa doença.

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Section: Resultsunclassified

Impacto do tratamento medicamentoso da endometriose nas questões profissionais, sexuais e econômicas das mulheres

Trindade¹,

Bianchin²,

Kluppel³

et al. 2021

SaudColetiv (Barueri)

View full text Add to dashboard Cite

show abstract

“…Anti-vascular endothelial growth factor agents have been shown to reduce endometriosis size and score in animal models [56]. Drugs targeting inflammation, such as tumor necrosis factor alpha inhibitors, Janus kinase inhibitors and mTOR inhibitors, are also reported with promising results [57]. These new options may also be used by itself or in combination with presently existing medications.…”

Section: Treatmentmentioning

confidence: 99%

Clinical Aspects of Adolescent Endometriosis

Nakamura

2021

Endocrines

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Early diagnosis and long-term management of endometriosis is important in adolescent girls considering their potential for future pregnancy and need for preventing disease progression. However, symptoms and clinical findings of adolescent endometriosis may differ from those of typical adult endometriosis, making diagnosis difficult. In adolescents, menstrual pain may present as acyclic and unresponsive to commonly used medication. Typical imaging findings in adult endometriosis, such as ovarian endometriotic cysts and fibrotic scars, are less common in adolescents. Peritoneal lesions, characteristic of early-stage endometriosis, are commonly found in this age group. It should be noted that endometriosis may also be found in adolescents before menarche, because of premenarcheal endometriosis or congenital uterine anomaly and outflow obstruction; the latter requiring surgical correction. Although surgery is reported to be effective for pain, postsurgical recurrence rate is high, and the effect of hormonal treatment is controversial. The optimal timing for surgical intervention also remains to be determined. Here, we aim to identify the unique characteristics of endometriosis in adolescents to achieve early diagnosis and optimal management for this group of patients.

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“…Several medical options are available to manage symptomatic endometriosis, a chronic inflammatory estrogen-dependent disease characterized by the presence and proliferation of endometrium outside the uterine cavity (1)(2)(3)(4). Endometriosis is associated with painful symptoms such as chronic pelvic pain, dysmenorrhea and dyspareunia, infertility, sexological difficulties, and psychological suffering (5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Medical Treatment for Endometriosis: Tolerability, Quality of Life and Adherence

Barbara

Buggio

Facchin

et al. 2021

Front. Glob. Womens Health

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Endometriosis is associated with painful symptoms, infertility, sexological difficulties, and psychological suffering. All these symptoms have a negative impact on the overall quality of life of women with the disease, with significant personal, social and economic costs. Several medical options are available to manage symptomatic endometriosis. The pharmacological treatment for endometriosis-related pain may be necessary for decades, or at least until there is a desire for pregnancy or physiologic menopause occurs. In this perspective, clinicians should consider not only the efficacy, but also side effects, tolerability, and costs, along with women's preferences toward different treatments. In this mini-review, we analyzed the pros and cons of the available drugs for the medical therapy of endometriosis, such as estrogen-progestins, progestins, GnRH agonist and GnRH antagonists.

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The role of pharmacotherapy in the treatment of endometriosis across the lifespan

Cited by 18 publications

References 69 publications

Impacto do tratamento medicamentoso da endometriose nas questões profissionais, sexuais e econômicas das mulheres

Impacto do tratamento medicamentoso da endometriose nas questões profissionais, sexuais e econômicas das mulheres

Clinical Aspects of Adolescent Endometriosis

Medical Treatment for Endometriosis: Tolerability, Quality of Life and Adherence

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