The role of pharmacological steroid therapy in preservation of renal function in severely injured patients requiring massive transfusion

Khan, Faraz A.; Ledgerwood, Anna M.; Lucas, Charles E.

doi:10.1007/s00068-015-0563-3

Eur J Trauma Emerg Surg

2015

DOI: 10.1007/s00068-015-0563-3

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The role of pharmacological steroid therapy in preservation of renal function in severely injured patients requiring massive transfusion

Faraz A. Khan

Anna M. Ledgerwood

Charles E. Lucas

Abstract: In the absence of larger studies, this study demonstrates that GC likely have no role in preserving renal function in severely injured patients.

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2023

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Cited by 1 publication

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Heterogeneity in defining multiple trauma: a systematic review of randomized controlled trials

Jeanmougin,

Cole,

Duceau

et al. 2023

Crit Care

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Introduction While numerous randomized controlled trials (RCTs) have been conducted in the field of trauma, a substantial portion of them are yielding negative results. One potential contributing factor to this trend could be the lack of agreement regarding the chosen definitions across different trials. The primary objective was to identify the terminology and definitions utilized for the characterization of multiple trauma patients within randomized controlled trials (RCTs). Methods A systematic review of the literature was performed in MEDLINE, EMBASE and clinicaltrials.gov between January 1, 2002, and July 31, 2022. RCTs or RTCs protocols were eligible if they included multiple trauma patients. The terms employed to characterize patient populations were identified, and the corresponding definitions for these terms were extracted. The subsequent impact on the population recruited was then documented to expose clinical heterogeneity. Results Fifty RCTs were included, and 12 different terms identified. Among these terms, the most frequently used were “multiple trauma” (n = 21, 42%), "severe trauma" (n = 8, 16%), "major trauma" (n = 4, 8%), and trauma with hemorrhagic shock" (n = 4, 8%). Only 62% of RCTs (n = 31) provided a definition for the terms used, resulting a total of 21 different definitions. These definitions primarily relied on the injury severity score (ISS) (n = 15, 30%), displaying an important underlying heterogeneity. The choice of the terms had an impact on the study population, affecting both the ISS and in-hospital mortality. Eleven protocols were included, featuring five different terms, with "severe trauma" being the most frequent, occurring six times (55%). Conclusion This systematic review uncovers an important heterogeneity both in the terms and in the definitions employed to recruit trauma patients within RCTs. These findings underscore the imperative of promoting the use of a unique and consistent definition.

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Heterogeneity in defining multiple trauma: a systematic review of randomized controlled trials

Jeanmougin,

Cole,

Duceau

et al. 2023

Crit Care

View full text Add to dashboard Cite

show abstract

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The role of pharmacological steroid therapy in preservation of renal function in severely injured patients requiring massive transfusion

Abstract: In the absence of larger studies, this study demonstrates that GC likely have no role in preserving renal function in severely injured patients.

Cited by 1 publication

References 20 publications

Heterogeneity in defining multiple trauma: a systematic review of randomized controlled trials

Heterogeneity in defining multiple trauma: a systematic review of randomized controlled trials

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