The role of phagocytosis in IL-8 production by human monocytes in response to lipoproteins on Staphylococcus aureus

Kang, Hee Jung; Jeong-mi, Ha; Kim, Han Sung; Lee, Haneulnari; Kurokawa, Kenji; Lee, Bok Luel

doi:10.1016/j.bbrc.2011.02.069

Cited by 23 publications

(13 citation statements)

References 17 publications

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“…The TLR2-dependent production of cytokines (TNFα, IL-10, IL-6, IL-8, and MIP2) in various cell types (mononuclear, epithelial, and endothelial cells) in response to this mutant was very much lower than that in response to the wild type (Stoll et al, 2005; Schmaler et al, 2009; Kang et al, 2011). However, in vivo studies with a murine model of septicemia are contradictory: in one study, the S. aureus lgt − mutant was more virulent than the WT strain (Bubeck Wardenburg et al, 2006), whereas another study reports lower virulence for this mutant (Schmaler et al, 2009).…”

Section: Role Of Lipoproteins In Tlr2-mediated Sensing Of S Aureusmentioning

confidence: 98%

The function of TLR2 during staphylococcal diseases

Fournier¹

2013

Front. Cell. Inf. Microbio.

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Staphylococcus aureus is a versatile pathogen causing a wide range of infections. It has been a major threat both in hospitals and in the community for decades. S. aureus is a pyogenic bacterium that elicits recruitment of polymorphonuclear leukocytes (neutrophils) to the site of infection. Neutrophils are among the first immune cells to migrate to an infection site attracted by chemoattractant gradients, usually initiated in response to inflammation. Neutrophil recruitment to an inflammation and/or infection site is a sophisticated process involving their interaction with endothelial and epithelial cells through adhesion molecules. Phagocytes have various receptors to detect pathogens, and they include Toll-like receptors (TLRs). TLRs have been extensively studied over the last 10 years and it is now established that they are critical during bacterial infections. However, the function of TLRs, and more particularly TLR2, during staphylococcal infections is still debated. In this review we will consider recent findings concerning the staphylococcal ligands sensed by TLR2 and more specifically the role of staphylococcal lipoproteins in TLR2 recognition. A new concept to emerge in recent years is that staphylococcal components must be phagocytosed and digested in the phagosome to be efficiently detected by the TLR2 of professional phagocytes. Neutrophils are an essential part of the immune response to staphylococcal infections, and in the second part of this review we will therefore describe the role of TLR2 in PMN recruitment in response to staphylococcal infections.

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Section: Role Of Lipoproteins In Tlr2-mediated Sensing Of S Aureusmentioning

confidence: 98%

The function of TLR2 during staphylococcal diseases

Fournier¹

2013

Front. Cell. Inf. Microbio.

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“…Some other cells, such as neutrophils, NK cells, endothelial and epithelial cells, and numerous tumor cells, can also be stimulated to produce IL‐8 . Such production is induced by proinflammatory agents, such as other cytokines: IL‐1, IL‐17, and TNF‐α, and also immune complexes and integrin activation or non‐immune stimulants, including lipopolysaccharides (LPS), bacteria, and viruses …”

Section: Interleukinmentioning

confidence: 99%

Abnormal peritoneal regulation of chemokine activation—The role of IL‐8 in pathogenesis of endometriosis

Sikora

Smycz‐Kubańska

Mielczarek‐Palacz

et al. 2017

American J Rep Immunol

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“…pathogens by various means, including antimicrobial peptides; proinflammatory cytokines, which are triggered by pattern recognition receptors; reactive oxygen species (ROS); and reactive nitrogen intermediates that are derived from nitric oxide (NO) (11)(12).…”

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confidence: 99%

Unsaturated guluronate oligosaccharide enhances the antibacterial activities of macrophages

et al. 2014

FASEB j.

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Alginate from marine seaweeds is receiving continuous attention owing to its wide physiological activities. Herein, we sought to elucidate possible effects of alginate-derived polyguluronate (PG) and unsaturated guluronate oligosaccharide (GOS) on antibacterial activities of macrophages. Our results showed that, in contrast to PG, GOS markedly increased the phagocytosis of IgG-opsonized Escherichia coli and Staphylococcus aureus and further inhibited the survival of intracellular bacteria in macrophages. In line with this, GOS treatment resulted in the enhanced expression of Fcγ receptors on macrophages. In addition, GOS activated NF-κB pathway, induced TNF-α secretion, and elevated the expression of inducible nitric oxide synthase and the production of nitric oxide. Meanwhile, GOS stimulated the production of reactive oxygen species in macrophages. Moreover, guluronate trimer to hexamer (G3-G6) in GOS exhibited significant activity that increased the bacterial phagocytosis of macrophages, with the pentamer (G5), displaying the highest activity. Finally, our in vivo results further confirmed that GOS but not PG significantly improved bacterial clearance in murine acute peritonitis. In conclusion, GOS enhances antibacterial activities of macrophages via modulating signaling pathways related to innate immunity, suggesting that GOS might be a promising therapeutic candidate to improve the host defense against bacterial infection.

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The role of phagocytosis in IL-8 production by human monocytes in response to lipoproteins on Staphylococcus aureus

Cited by 23 publications

References 17 publications

The function of TLR2 during staphylococcal diseases

The function of TLR2 during staphylococcal diseases

Abnormal peritoneal regulation of chemokine activation—The role of IL‐8 in pathogenesis of endometriosis

Unsaturated guluronate oligosaccharide enhances the antibacterial activities of macrophages

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