The role of periodontal treatment associated with photodynamic therapy on the modulation of systemic inflammation in the experimental model of asthma and periodontitis

Murakami-Malaquias-da-Silva, Felipe; Rosa, Ellen Perim; Oliveira, Jessica Gonzaga; Avelar, Isabella Sena; Palma-Cruz, Marlon; Silva, Joao Gabriel Fernandes; Rigonato‐Oliveira, Nicole Cristine; Bussadori, Sandra Kalil; Negreiros, Renata Matalon; Oliveira, Ana Paula Ligeiro de; Lino-dos-Santos-Franco, Adriana; Horliana, Anna Carolina Ratto Tempestini

doi:10.1016/j.pdpdt.2019.101619

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…Treatment with antibacterial substances providing immunity against the bacteria responsible for inducing periodontitis should be in the form of vaccines targeting the main virulence factors of microorganisms; so far, vaccination against PD has only been reported in mice [32]. Therapies such as photodynamic, gene and mesenchymal stem cell therapies can slow the progression of periodontal disease by their action on the immune system [33][34][35]. Bacterial lysates act to non-specifically increase the body's systemic immunity by acting on non-specific defense mechanisms through increased type A antibodies in mucous membranes, phagocytic activity and INF-y production.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Effect on Periodontitis of Antibiotic Therapy and Bacterial Lysate Treatment

Ancuţa,

Alexandru,

Muselin

et al. 2024

IJMS

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Periodontitis is an inflammatory process that starts with soft tissue inflammation caused by the intervention of oral bacteria. By modulating local immunity, it is possible to supplement or replace current therapeutic methods. The aim of this study was to compare the effects of an immunostimulatory treatment with the antibiotherapy usually applied to periodontitis patients. On a model of periodontitis induced in 30 rats (divided into three equal groups) with bacterial strains selected from the human oral microbiome (Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum and Streptococcus oralis), we administered antibiotics, bacterial lysates and saline for 10 days. Clinically, no significant lesions were observed between the groups, but hematologically, we detected a decrease in lymphocyte and neutrophil counts in both the antibiotic and lysate-treated groups. Immunologically, IL-6 remained elevated compared to the saline group, denoting the body’s effort to compensate for bone loss due to bacterial action. Histopathologically, the results show more pronounced oral tissue regeneration in the antibiotic group and a reduced inflammatory reaction in the lysate group. We can conclude that the proposed bacterial lysate has similar effects to antibiotic therapy and can be considered an option in treating periodontitis, thus eliminating the unnecessary use of antibiotics.

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Section: Discussionmentioning

confidence: 99%

Assessment of the Effect on Periodontitis of Antibiotic Therapy and Bacterial Lysate Treatment

Ancuţa,

Alexandru,

Muselin

et al. 2024

IJMS

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“…[ 59 60 ] Although PDT shows promising results, given the problems that refractory cases show, it may not be suitable for all cases. [ 31 61 62 63 64 ]…”

Section: Discussionmentioning

confidence: 99%

Applications of lasers in refractory periodontitis: A narrative review

Varma

AlShayeb

Narayanan

et al. 2020

J Int Soc Prevent Communit Dent

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A BSTRACT Objective: The purpose of the study is to evaluate the various lasers in dentistry and to investigate if it can be used for treatment of refractory periodontitis. Methods: The study followed partially the PRISMA guidelines as it is a narrative review. A number of articles were selected from a period of 1980 to 2020 from databases, PubMed, PubMed central, Cochrane and Scopus. Articles related to the effects of lasers on periodontitis both refractory and aggressive were investigated. Results: After reviewing the literature, 70 articles were found, related to application of lasers in periodontal diseases. Out of the 70, 11 articles pertained to the effect of laser for the treatment of Refractory and inflammatory periodontitis. 5 articles related to experimental animal models, one pertaining to in-vitro and six studies related to in-vivo in human cohorts. Discussion: It was found that lasers if used in controlled parameters by incorporating laser assisted treatment such as Photodynamic therapy and low level laser therapy can be of use as an adjunct therapy for treatment of refractory periodontitis. The use of different wavelengths in the initial and maintenance phase of periodontal disease plays a positive role. The presence of in-vitro and animal model studies is one of the limitation to this study. The available studies have shown marked reduction in inflammation and better clinical and microbiological parameters. The drawback of this study is the limited literature involving laser management for refractory periodontitis in human cohorts. Conclusion: Different wavelengths of laser and choice of laser assisted periodontal treatment plays an important role in the overall progress and prognosis of periodontal disease activity.

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“…The periodontal therapy (PT) associated with photodynamic therapy (PDT) reduced the expression of TNF-a in gingiva (222). Indocyanine green (ICG)-diode laser-based photothermal therapy (PTT) decreased the expression of IL-1b and MMP-8 (223).…”

Section: Other Therapiesmentioning

confidence: 99%

Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives

Yang

Pang

et al. 2021

Front. Immunol.

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Periodontitis is one of the most common dental diseases. Compared with healthy periodontal tissues, the immune microenvironment plays the key role in periodontitis by allowing the invasion of pathogens. It is possible that modulating the immune microenvironment can supplement traditional treatments and may even promote periodontal regeneration by using stem cells, bacteria, etc. New anti-inflammatory therapies can enhance the generation of a viable local immune microenvironment and promote cell homing and tissue formation, thereby achieving higher levels of immune regulation and tissue repair. We screened recent studies to summarize the advances of the immunomodulatory treatments for periodontitis in the aspects of drug therapy, microbial therapy, stem cell therapy, gene therapy and other therapies. In addition, we included the changes of immune cells and cytokines in the immune microenvironment of periodontitis in the section of drug therapy so as to make it clearer how the treatments took effects accordingly. In the future, more research needs to be done to improve immunotherapy methods and understand the risks and long-term efficacy of these methods in periodontitis.

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The role of periodontal treatment associated with photodynamic therapy on the modulation of systemic inflammation in the experimental model of asthma and periodontitis

Cited by 6 publications

References 41 publications

Assessment of the Effect on Periodontitis of Antibiotic Therapy and Bacterial Lysate Treatment

Assessment of the Effect on Periodontitis of Antibiotic Therapy and Bacterial Lysate Treatment

Applications of lasers in refractory periodontitis: A narrative review

Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives

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