The Role of PEDF in Tumor Growth and Metastasis

Hoshina, Daichi; Abe, Riichiro; Yamagishi, Sho‐ichi; Shimizu, Hiroaki

doi:10.2174/156652410791065327

Cited by 44 publications

(34 citation statements)

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“…PEDF and VEGF have an inverse relationship with each other, especially in cancer in which low levels of PEDF are associated with the increased incidence of metastasis and poor malignancy prognosis (43). PEDF suppressed proliferation and induced apoptosis of the tumor cell (44). The increased ratio of VEGF/PEDF is required for angiogenesis and tumor growth.…”

Section: Discussionmentioning

confidence: 97%

TFAP2A Regulates Nasopharyngeal Carcinoma Growth and Survival by Targeting HIF-1α Signaling Pathway

Shi

Xie

Zhang

et al. 2014

Cancer Prevention Research

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TFAP2A is a transcription factor that orchestrates a variety of cell processes, including cell growth and tissue differentiation. However, the regulation of TFAP2A in human nasopharyngeal carcinoma tumorigenesis and its precise mechanism of action remain largely unknown. In this study, we investigated the biologic role and clinical significance of TFAP2A in nasopharyngeal carcinoma growth and progression and identified the underlying molecular mechanisms. We found that TFAP2A was highly expressed in various nasopharyngeal carcinoma cell lines and tumor tissue specimens and was significantly correlated with hypoxia-inducible factor-1a (HIF-1a) expression. A positive correlation of TFAP2A overexpression with advanced tumor stage, local invasion, clinical progression, and poor prognosis of patients with nasopharyngeal carcinomas were also observed. Moreover, we found that knockdown of TFAP2A expression by siRNA significantly inhibited tumor cell growth in nasopharyngeal carcinoma cell lines and in a subcutaneous xenograft mouse model by targeting the HIF-1a-mediated VEGF/pigment epithelium-derived factor (PEDF) signaling pathway. Treatment of nasopharyngeal carcinoma cells with TFAP2A siRNA dramatically inhibited the expression and the release of VEGF protein but did not change the level of PEDF protein, resulting in a significant reduction of the ratio of VEGF/PEDF. Pretreatment with a HIF-1a siRNA did not significantly change the TFAP2A siRNA-mediated inhibition in cell viability. Our results indicate that TFAP2A regulates nasopharyngeal carcinoma growth and survival through the modulation of the HIF-1a-mediated VEGF/PEDF signaling pathway, and suggest that TFAP2A could be a potential prognostic biomarker and therapeutic target for nasopharyngeal carcinoma treatment. Cancer Prev Res; 7(2); 266-77. Ó2013 AACR.

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Section: Discussionmentioning

confidence: 97%

TFAP2A Regulates Nasopharyngeal Carcinoma Growth and Survival by Targeting HIF-1α Signaling Pathway

Shi

Xie

Zhang

et al. 2014

Cancer Prevention Research

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“…Many studies have demonstrated that PEDF is an effective inhibitor of angiogenesis and has promising efficacy in the treatment of some tumors (16)(17)(18). In women with endometriosis, increased angiogenic activity has been demonstrated in peritoneal fluid, and strong expression of angiogenic factor has been demonstrated in active lesions (3,4).…”

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confidence: 99%

Decreased concentrations of pigment epithelium–derived factor in peritoneal fluid of patients with endometriosis

Chen

Fan

Huang

et al. 2011

Fertility and Sterility

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“…It is believed that PEDF has neuroprotectiveproperties (10) acts as an antioxidant and antiinflammatory agent (11) inhibits cellular proliferation and supports cell differentiation. (12) …”

Section: Resultsmentioning

confidence: 99%

Serum pigment epithelium derived factor as a new marker in the metabolic syndrome

Sabry¹,

Shaaer²,

Hammady³

2017

Int J Recent Sci Res

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Background: Metabolic syndrome represents a cluster of related metabolic abnormalities, including central obesity, hyperglycemia, hypertension, dyslipidemia, and insulin resistance, with insulin resistance and central obesity in particular recognized as causative factors. Aim of the study: to determine serum level of Serum pigment epithelium derived factor (PEDF) and to examine whether PEDF serum level are associated with metabolic syndrome risk factor. Materials and Methods: The present study was conducted on 90 subjects subdivided into two groups. Patient group included 70 patients with metabolic syndrome attending the outpatient clinic in Benha University Hospital. and control group, this group included 20 apparently healthy individuals, Blood samples were drawn from all subjects to assess serum levels of PEDF, Hs-CRP, lipid profile, F.B.S, creatinine and uric acid. Results: PEDF level was significantly higher in patient group than control group, significant elevation of Hs-CRP, FBS, TG, LDL-cholesterol and uric acid in patient group versus control group and significant decrease of HDL-cholesterol in patient group versus control group. Significant positive correlation between PEDF (patient group) and each of the components of Metabolic syndromeas BMI,WC, LDL-cholesterol and total cholesterol, triglyceride, systolic &diastolic blood pressure and the accumulation of the number of this component collectively. Conclusion: Based on the evidence presented within the study, PEDF correlate significantly with metabolic syndrome and could provide a minimally-invasive mean for early detection and specific treatment of this disorder. Further research is encouraged to determine the efficacy of applying this biomarker fordiagnosis of metabolic syndrome.

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The Role of PEDF in Tumor Growth and Metastasis

Cited by 44 publications

References 0 publications

TFAP2A Regulates Nasopharyngeal Carcinoma Growth and Survival by Targeting HIF-1α Signaling Pathway

TFAP2A Regulates Nasopharyngeal Carcinoma Growth and Survival by Targeting HIF-1α Signaling Pathway

Decreased concentrations of pigment epithelium–derived factor in peritoneal fluid of patients with endometriosis

Serum pigment epithelium derived factor as a new marker in the metabolic syndrome

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