The role of past intake of vitamin E in early cataract changes

Nadalin, Gabriella; Robman, Liubov; McCarty, Catherine A.; Garrett, S. K.M.; McNeil, John J; Taylor, Hugh R.

doi:10.1076/opep.6.2.105.1561

Cited by 35 publications

(15 citation statements)

References 2 publications

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“…Upon closer examination, forty-seven articles were excluded for the following reasons: thirty-six articles were irrelevant to the interest of the exposure or the outcome, seven articles (30)(31)(32)(33)(34)(35)(36) did not provide OR/RR and its 95 % CI, three articles (37)(38)(39) were duplicated studies and one article (40) was a review. Finally, twenty-seven articles (6,(10)(11)(12)(13)(15)(16)(17)(19)(20)(21)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56) were included in the present meta-analysis. The detailed literature search for article inclusion is shown in Fig.…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

“…First, the dose of supplementation used differed in the different original studies, and the use of high-dose vitamin E supplements may be associated with increased risk of ARC. Second, in the total of ten included studies on supplemental vitamin E intake and ARC risk, five were randomized controlled trials (19,20,44,47,52) that were based on populations with different nutritional status. In addition, in two randomized controlled trials (19,47) the subjects were volunteers, thus volunteer bias might be introduced.…”

Section: Rrmentioning

confidence: 99%

“…Second, in the total of ten included studies on supplemental vitamin E intake and ARC risk, five were randomized controlled trials (19,20,44,47,52) that were based on populations with different nutritional status. In addition, in two randomized controlled trials (19,47) the subjects were volunteers, thus volunteer bias might be introduced. Third, in three of five randomized controlled trials (19,44,47) and one cohort study (13) , the intervention periods of less than 5 years are too short to influence the natural history of cataract development.…”

Section: Rrmentioning

confidence: 99%

“…The association between supplemental vitamin E intake and ARC risk was examined in ten articles (10,13,16,(19)(20)(21)44,47,49,52) with ten studies including 358 007 participants and 5147 cases. Compared with the lowest category, the pooled RR of ARC for the highest category was 0·92 (95 % CI 0·78, 1·07; I 2 = 74·2 %; P heterogeneity < 0·001); no statistically significant association was observed between supplemental vitamin E intake and risk of ARC.…”

Section: Supplemental Vitamin E Intake and Risk Of Age-related Cataractmentioning

confidence: 99%

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Vitamin E and risk of age-related cataract: a meta-analysis

Zhang¹,

Jiang²,

Xie³

et al. 2015

Public Health Nutr.

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Objective: We conducted a meta-analysis to evaluate the relationship between vitamin E and age-related cataract (ARC). Design: The fixed-or random-effect model was selected based on heterogeneity. Meta-regression was used to explore potential sources of between-study heterogeneity. Publication bias was evaluated using Begg's test. The dose-response relationship was assessed by a restricted cubic spline model. Setting: Relevant studies were identified by a search of PubMed and the Cochrane Library to May 2014, without language restrictions. Subjects: Studies involved samples of people of all ages. Results: Dietary vitamin E intake, dietary and supplemental vitamin E intake, and high serum tocopherol levels were significantly associated with decreased risk of ARC, the pooled relative risk was 0·73 (95 % CI 0·58, 0·92), 0·86 (95 % CI 0·75, 0·99) and 0·77 (95 % CI 0·66, 0·91), respectively. Supplemental vitamin E intake was non-significantly associated with ARC risk (relative risk = 0·92; 95 % CI 0·78, 1·07). The findings from dose-response analysis showed evidence of a non-linear association between dietary vitamin E intake and ARC. The risk of ARC decreased with dietary vitamin E intake from 7 mg/d (relative risk = 0·94; 95 % CI 0·90, 0·97). Conclusions: The findings of the meta-analysis indicated that dietary vitamin E intake, dietary and supplemental vitamin E intake, and high level of serum tocopherol might be significantly associated with reduced ARC risk.

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Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

Section: Rrmentioning

confidence: 99%

Section: Rrmentioning

confidence: 99%

Section: Supplemental Vitamin E Intake and Risk Of Age-related Cataractmentioning

confidence: 99%

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Vitamin E and risk of age-related cataract: a meta-analysis

Zhang¹,

Jiang²,

Xie³

et al. 2015

Public Health Nutr.

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“…In the Vitamin E and Cataract Prevention Study, Nadalin et al [60] showed that when Australian women and men (55-80 years old) were orally supplied with vitamin E (500 IU/day), there was a significant association between prior vitamin E supplementation and the absence of cortical opacity, after adjusting for age, while there was no apparent protective role of prior vitamin E supplementation in terms of nuclear opacity and nuclear color regardless of the level, regularity or duration of vitamin E intake. Olmedilla et al [61] have shown in elderly Spanish women with age-related cataracts that when improvement of visual function is compared between subjects supplied with and without ␣-tocopherol (100 mg/day) for 24 months, this vitamin E supplementation has no beneficial effect on the visual performance.…”

Section: Effect Of Vitamin E Supplementation On Cataract Development mentioning

confidence: 99%

Possibility of Clinical Application of Vitamin E to Cataract Prevention

Ohta

2004

J. Clin. Biochem. Nutr.

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Summary It has been implicated that oxidative stress is involved in the development of aged-related and diabetic cataracts in humans and also in cataract development in a variety of in vivo experimental cataract models. Therefore, this article will review the possibility of the clinical application of vitamin E to cataract prevention, based on data concerning the level of vitamin E in normal and cataractous lenses of humans and experimental animals, the relationship between dietary vitamin E intake and the risk of cataracts, the effect of vitamin E supplementation on cataract development in humans, and the effect of oral or parenteral vitamin E treatment or topical vitamin E instillation on cataract development in a variety of in vivo experimental cataract models. These data reported so far may allow us to think of a possibility that vitamin E is clinically applied to cataract development.

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A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E and Beta Carotene for Age-Related Cataract and Vision Loss

2001

Arch Ophthalmol

479

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Background: Experimental and observational data suggest that micronutrients with antioxidant capabilities may retard the development of age-related cataract. Objective: To evaluate the effect of a high-dose antioxidant formulation on the development and progression of age-related lens opacities and visual acuity loss. Design: The 11-center Age-Related Eye Disease Study (AREDS) was a double-masked clinical trial. Participants were randomly assigned to receive daily oral tablets containing either antioxidants (vitamin C, 500 mg; vitamin E, 400 IU; and beta carotene, 15 mg) or no antioxidants. Participants with more than a few small drusen were also randomly assigned to receive tablets with or without zinc (80 mg of zinc as zinc oxide) and copper (2 mg of copper as cupric oxide) as part of the age-related macular degeneration trial. Baseline and annual (starting at year 2) lens photographs were graded at a reading center for the severity of lens opacities using the AREDS cataract grading scale. Main Outcome Measures: Primary outcomes were (1) an increase from baseline in nuclear, cortical, or posterior subcapsular opacity grades or cataract surgery, and (2) at least moderate visual acuity loss from baseline (Ն15 letters). Primary analyses used repeated-measures logistic regression with a statistical significance level of P = .01. Serum level measurements, medical histories, and mortality rates were used for safety monitoring. Results: Of 4757 participants enrolled, 4629 who were aged from 55 to 80 years had at least 1 natural lens present and were followed up for an average of 6.3 years. No statistically significant effect of the antioxidant formulation was seen on the development or progression of age-related lens opacities (odds ratio=0.97, P=.55). There was also no statistically significant effect of treatment in reducing the risk of progression for any of the 3 lens opacity types or for cataract surgery. For the 1117 participants with no age-related macular degeneration at baseline, no statistically significant difference was noted between treatment groups for at least moderate visual acuity loss. No statistically significant serious adverse effect was associated with treatment. Conclusion: Use of a high-dose formulation of vitamin C, vitamin E, and beta carotene in a relatively wellnourished older adult cohort had no apparent effect on the 7-year risk of development or progression of agerelated lens opacities or visual acuity loss.

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The role of past intake of vitamin E in early cataract changes

Abstract: Prior vitamin E supplementation may protect VECAT participants from developing at least early cortical cataracts. No apparent protective role in terms of nuclear opacities and nuclear color was found regardless of the level, regularity or duration of intake.

Cited by 35 publications

References 2 publications

Vitamin E and risk of age-related cataract: a meta-analysis

Vitamin E and risk of age-related cataract: a meta-analysis

Possibility of Clinical Application of Vitamin E to Cataract Prevention

A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E and Beta Carotene for Age-Related Cataract and Vision Loss

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