The Role of Parathyroid Hormone and Vitamin D Serum Concentrations in Patients with Cardiovascular Diseases

Kolaszko, Agnieszka; Nowalany-Kozielska, Ewa; Ceranowicz, Piotr; Morawiec, Beata; Kubiak, Grzegorz

doi:10.1155/2018/5287573

Cited by 12 publications

(7 citation statements)

References 46 publications

(34 reference statements)

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“…[8] It is demonstrated that elevated serum PTH level is an independent factor in myocardial injury and all-cause mortality in post-MI patients. [3334] In the current study, atorvastatin did not reverse the increasing of PTH level after acute MI in Vitamin D-deficient/insufficient patients but caused a nonsignificant drop in PTH in Vitamin D-sufficient patients. It has been proposed that the ability of atorvastatin 80 mg daily might not be enough to reduce serum PTH level; however, it seems that the modifying effect of atorvastatin on serum PTH level might be depending on Vitamin D status.…”

Section: Discussioncontrasting

confidence: 43%

Early effects of atorvastatin on Vitamin D and parathyroid hormone serum levels following acute myocardial infarction

et al. 2019

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Objective: High Vitamin D serum level after acute myocardial infarction (aMI) has shown to increase cardiac reconstruction by increasing cell survival and enhancing angiogenesis. Atorvastatin has a well-defined role in both primary and secondary prevention of cardiovascular diseases. It is suggested that this effect may partly be attributable to raising 25-hydroxyvitamin D concentrations. The aim of this study was to evaluate atorvastatin effects on Vitamin D and parathyroid hormone (PTH) levels early after aMI. Methods: All patients admitted with aMI in Imam Reza Hospital, Mashhad, Iran, from July 2014 to March 2015, were included in this pre- and postintervention study. Serum levels of Vitamin D and PTH were measured on admission and the 3 rd day after administration of atorvastatin 80 mg/day. Findings: A total of 69 post-aMI patients (47 males and 22 females) were enrolled in this study. Serum levels of Vitamin D and PTH were significantly higher (23.52 ng/ml and 46.04 pg/ml, respectively) after 72 h of atorvastatin therapy compared to the baseline (19.66 ng/ml and 31.19 pg/ml, respectively) ( P = 0.004 and 0.002, respectively). Conclusion: The early post-aMI beneficial effects of atorvastatin can be attributed to increased serum Vitamin D level; however, atorvastatin cannot significantly decrease serum PTH level after aMI. Further studies are needed to elucidate the clinical effect of atorvastatin.

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Section: Discussioncontrasting

confidence: 43%

Early effects of atorvastatin on Vitamin D and parathyroid hormone serum levels following acute myocardial infarction

et al. 2019

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“…[17] PTH is a critical regulator of bone and mineral metabolic process, and its biosynthesis is influenced by changes in blood calcium levels, which trigger responses in several pathways. [18] PTH levels in relation to 25(OH)D levels are often used to determine Vitamin D insufficiency levels.…”

Section: Discussionmentioning

confidence: 99%

Serum Fibroblast Growth Factors 23, Chemerin, and Vitamin D Levels in Patients with Psoriasis

Tawfeeq

Anzy²,

Sarhat

2022

Cihan U Erbil SCI J

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The aim of the study was to compare the levels of fibroblast growth factor 23 (FGF23) and chemerin, as well as Vitamin D in psoriasis sufferers and healthy controls. From 2021 to 2022, ninety subjects were studied. The study comprised 45 individuals with psoriasis and 45 healthy controls. Serum fasting FGF23 and chemerin levels of the study group were examined by sandwich enzyme-linked immunosorbent assay. The results demonstrate that the mean serum FGF23 and chemerin quantities in psoriasis patients were greater than in controls, with a statistically significant. Patients with psoriasis, on the other hand, had considerably lower blood Vitamin D levels than healthy controls. These findings demonstrate that psoriatic patients have lower Vitamin D levels than healthy controls, and they add to the growing body of data linking FGF23, chemerin Vitamin D levels, and the course of psoriasis.

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“…It was highly significant, above (p < 0.001) than in the studied population. and ethnicity-dependent vitamin D doses ranging between 400 and 2000 IU/day [18,19].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency and anemia is highly prevalent and dependent on the etiology of heart failure: A pilot study

et al. 2021

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Background: Anemia and vitamin D deficiency are common factors in chronic heart failure (CHF). The aim of this study was to assess vitamin D levels as well as its binding protein and anemia in relation to a cause of CHF: coronary heart disease, valvular disease and cardiomyopathy. Methods: One hundred and sixteen consecutive patients (36 females and 80 males) with CHF were admitted for percutaneous coronary interventions (PCI). Hemoglobin concentration, serum creatinine, B-type natriuretic peptide (BNP), 25-hydroxyvitamin D [25(OH)D] and its binding protein-VDBP were measured. Results: The prevalence of anemia was 22%. BNP was the highest in the group with coronary artery disease. Ejection fraction was the lowest in cardiomyopathy group. 25(OH)D was lowest in valvular disease group, significantly lower than in the coronary artery group. A similar pattern of change showed vitamin D binding protein. The prevalence of vitamin D deficiency (level below 20 ng/mL) in the whole group was 95%, in 49% of the patients 25(OH)D was below 10 ng/mL. In univariate analysis 25(OH)D correlated with hemoglobin, red blood cell count, hematocrit, mean corpuscular volume and BNP in patients with CHF in the whole group. In multiple regression analysis, predictors of 25(OH)D were estimated, glomerular filtration rate, BNP and valvular disease. Conclusions: 25(OH)D deficiency is common in CHF patients. Valvular disease is associated the most severe vitamin D deficiency and worsened kidney function. A higher prevalence of anemia in CHF due to coronary heart disease may be associated with wider use of angiotensin converting enzyme inhibitors and acetylsalicylic acid. Heart and kidney function are predictors of 25(OH)D level in the patients of this study.

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The Role of Parathyroid Hormone and Vitamin D Serum Concentrations in Patients with Cardiovascular Diseases

Cited by 12 publications

References 46 publications

Early effects of atorvastatin on Vitamin D and parathyroid hormone serum levels following acute myocardial infarction

Early effects of atorvastatin on Vitamin D and parathyroid hormone serum levels following acute myocardial infarction

Serum Fibroblast Growth Factors 23, Chemerin, and Vitamin D Levels in Patients with Psoriasis

Vitamin D deficiency and anemia is highly prevalent and dependent on the etiology of heart failure: A pilot study

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