The role of parasites and fungi in secondary infertility

Kranjcic-Zec, F Ivana; Dzamic, M Aleksandar; Mitrovic, M.; Arsenijevic-Arsic, Valentina; Radonjić, Vidosava

doi:10.2298/mpns0402030k

Cited by 17 publications

(16 citation statements)

References 2 publications

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“…An inhibitory role of T. vaginalis metabolites (Han et al. , 2004) or of a soluble extract (Kranjcić‐Zec et al. , 2004) of these protozoan on sperm motility was further reported.…”

Section: Effects Of Microorganismsmentioning

confidence: 98%

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Male accessory gland infection and sperm parameters (review)

Vignera

Vicari

Condorelli

et al. 2011

International Journal of Andrology

164

125

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Male accessory gland infection (MAGI) has been identified among those diagnostic categories which have a negative impact on the reproductive function and fertility in males (Rowe et al., World Health Organization Manual for the Standardised Investigation and Diagnosis of the Infertile Couple, Cambridge University Press, Cambridge, 1993). MAGI is a hypernym which groups the following different clinical categories: prostatitis, prostate-vesiculitis and prostate-vesiculo-epididymitis. Some of the characteristics they share are: common diseases, mainly have a chronic course, rarely cause obstruction of the seminal pathways, can have an unpredictable intracanicular spread to one or more sexual accessory glands of the reproductive tract, as well as to one or both sides. In this review, we show that all components involving the inflammatory response (from the agents which first trigger it to each component of the inflammatory response dynamic) can deteriorate conventional and/or non-conventional sperm parameters arising from one or more of the following mechanisms: altered secretory function of the epididymis, seminal vesicles, and prostate which reduce the antioxidant properties or scavenging role of the seminal plasma; deterioration of spermatogenesis; and (unilateral or bilateral) organic or functional sub-obstruction of the seminal tract.

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“…An inhibitory role of T. vaginalis metabolites (Han et al. , 2004) or of a soluble extract (Kranjcić‐Zec et al. , 2004) of these protozoan on sperm motility was further reported.…”

Section: Effects Of Microorganismsmentioning

confidence: 98%

“…, 2004) of these protozoan on sperm motility was further reported. Incubation with a T. vaginalis soluble factor also resulted in increased viscosity, number of debris and in vitro sperm membrane damage (Kranjcić‐Zec et al. , 2004).…”

Section: Effects Of Microorganismsmentioning

confidence: 99%

Male accessory gland infection and sperm parameters (review)

Vignera

Vicari

Condorelli

et al. 2011

International Journal of Andrology

164

125

View full text Add to dashboard Cite

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“… 5 Subsequent studies have attempted to establish a mechanism by which these abnormalities arise. 7 10 Almost all of the previous studies have concentrated on contact-dependent adhesion of T. vaginalis on sperm cells, whereas the possible consequences of substances secreted by T. vaginalis remain largely unexamined. Little information is available on the effect of the extracellular polymeric substances (EPS) of T. vaginalis on the functional integrity and fertilizing capacity of sperm.…”

Section: Introductionmentioning

confidence: 99%

The secretory products of Trichomonas vaginalis decrease fertilizing capacity of mice sperm in vitro

et al. 2015

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Trichomonas vaginalis infection is one of the most prevalent sexually transmitted infections in humans and is now recognized as an important cause of infertility in men. There is little information about the effect of extracellular polymeric substances (EPS) from T. vaginalis on sperm, but previous reports do not provide a conclusive description of the functional integrity of the sperm. To investigate the impact of EPS on the fertilizing capacity of sperm, we assessed sperm motility, acrosomal status, hypo-osmotic swelling, and in vitro fertilization rate after incubating the sperm with EPS in vitro using mice. The incubation of sperm with EPS significantly decreased sperm motility, viability, and functional integrity in a concentration and time-dependent manner. These effects on sperm quality also resulted in a decreased fertilization rate in vitro. This is the first report that demonstrates the direct negative impact of the EPS of T. vaginalis on the fertilization rate of sperm in vitro. However, further study should be performed using human sperm to determine if EPS has similar negative impact on human sperm fertilizing capacity in vitro.

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“…[1] In addition to bacteria, other pathogens can also affect semen quality and result in infertility as a consequence. [2] The roles of parasites and fungi in induction of infertility are confirmed. [2] The most well-known virus-induced infection leading to infertility is mumps.…”

mentioning

confidence: 99%

“…[2] The roles of parasites and fungi in induction of infertility are confirmed. [2] The most well-known virus-induced infection leading to infertility is mumps. Indeed, mumps result in orchitis.…”

mentioning

confidence: 99%