The Role of p53 in Cell Cycle Regulation

Shaw, Phillip

doi:10.1016/s0344-0338(96)80088-4

Cited by 113 publications

(82 citation statements)

References 65 publications

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“…We did not correlate our data with p53 expression, because it does not seem to be of pathogenetic significance in pituitary tumors. 23,32,33,45,48,55,63 Tumor proliferation markers, such as the Ki-67-targeted MIB-1 labeling index, were observed by others 47 and our group 42,43,68,71,72 to correlate with more aggressive biological pituitary adenoma behavior, such as an increased growth rate and invasive growth. These recent data support our previous results, although MIB-1 did not achieve significance between the grades, most likely because all of the included tumors were macroadenomas.…”

Section: Mib-1 Indexmentioning

confidence: 53%

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Invasion of the cavernous sinus space in pituitary adenomas: endoscopic verification and its correlation with an MRI-based classification

Micko¹,

Wöhrer

Wolfsberger³

et al. 2015

JNS

373

253

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abbreviatioNs CS = cavernous sinus; ER = endocrinological remission; GTR = gross-total resection; ICA = internal carotid artery. submitted May 22, 2014. accepted December 2, 2014. iNclude wheN citiNg Published online February 6, 2015; DOI: 10.3171/2014.12.JNS141083. disclosure The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper. obJect An important prognostic factor for the surgical outcome and recurrence of a pituitary adenoma is its invasiveness into parasellar tissue, particularly into the space of the cavernous sinus (CS). The aims of this study were to reevaluate the existing parasellar classifications using an endoscopic technique and to evaluate the clinical and radiological outcomes associated with each grade. methods The authors investigated 137 pituitary macroadenomas classified radiologically at least on one side as Grade 1 or higher (parasellar extension) and correlated the surgical findings using an endoscopic technique, with special reference to the invasiveness of the tumor into the CS. In each case, postoperative MRI was performed to evaluate the gross-total resection (GTR) rate and the rate of endocrinological remission (ER) in functioning adenomas. results The authors found a 16% rate of CS invasion during surgery for these macroadenomas. Adenomas radiologically classified as Grade 1 were found to be invasive in 1.5%, and the GTR/ER rate was 83%/88%. For Grade 2 adenomas, the rate of invasion was 9.9%, and the GTR/ER rate was 71%/60%. For Grade 3 adenomas, the rate of invasion was 37.9%, and the GTR/ER rate was 75%/33%. When the superior compartment of the CS (Grade 3A) was involved, the authors found a rate of invasion that was lower (p < 0.001) than that when the inferior compartment was involved (Grade 3B). The rate of invasion in Grade 3A adenomas was 26.5% with a GTR/ER rate of 85%/67%, whereas for Grade 3B adenomas, the rate of surgically observed invasion was 70.6% with a GTR/ER rate of 64%/0%. All of the Grade 4 adenomas were invasive, and the GTR/ER rate was 0%. A comparison of microscopic and endoscopic techniques revealed no difference in adenomas with Grade 1 or 4 parasellar extension. In Grade 2 adenomas, however, the CS was found by the endoscopic technique to be invaded in 9.9% and by microscopic evaluation to be invaded in 88% (p < 0.001); in Grade 3 adenomas, the difference was 37.9% versus 86%, respectively (p = 0.002). Grade 4 adenomas had a statistically significant lower rate of GTR than those of all the other grades. In case of ER only, Grade 1 adenomas had a statistically significant higher rate of remission than did Grade 3B and Grade 4 adenomas. coNclusioNs The proposed classification proved that with increasing grades, the likelihood of surgically observed invasion rises and the chance of GTR and ER decreases. The direct endoscopic view confirmed the low rate of invasion of Grade 1 adenomas but showed significantly lower rates of invasion in Grade 2 and 3 adenomas than those previousl...

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Section: Mib-1 Indexmentioning

confidence: 53%

“…A radiological classification of the parasellar growth of adenomas had been proposed previously and applied widely. 13,21,27,44,45,63,78 In the higher grades of the classification scale, invasion of the CS space is observed more often and the cure rate decreases inversely.…”

Section: Discussion Invasivenessmentioning

confidence: 99%

Invasion of the cavernous sinus space in pituitary adenomas: endoscopic verification and its correlation with an MRI-based classification

Micko¹,

Wöhrer

Wolfsberger³

et al. 2015

JNS

373

253

View full text Add to dashboard Cite

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“…Cellular senescence is stimulated by the presence of oncogene activation or presence of DNA damage. Its ability to arrest the cell cycle in the G1/G2 phase is dependent on its response to stressful stimuli [25].…”

Section: Tumour Suppressor Gene Dysfunctionmentioning

confidence: 99%

Osteosarcoma: From Molecular Biology to Mesenchymal Stem Cells

Broadhead¹,

Sivaji²,

Balogh³

et al. 2017

Osteosarcoma - Biology, Behavior and Mechanisms

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Osteosarcoma is the most common primary malignant tumour of bone. Currently, despite treatment with multi-agent chemotherapy and limb salvage surgery, the iveyear survival rate for osteosarcoma remains at 70%. The pathogenesis of osteosarcoma is complex and involves alterations in cellular apoptosis, adhesion, migration, invasion and molecular signalling. Research most recently has focused on the molecular basis of the disease with the goal of identifying novel therapeutic targets. To this end, mesenchymal stem cells (MSCs) have been identiied to play a role in sarcomagenesis. MSC transformation may give rise to tumours, whereas interactions of MSCs with osteosarcoma cells in the tumour microenvironment may cause increased cell proliferation. This is in stark contrast to the role of MSCs as a promising source for tissue repair and regeneration. In order to utilize MSCs for biological reconstruction in the seting of osteosarcoma, further research is necessary to delineate the role of MSCs in osteosarcoma transformation and progression.

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“…Immunohistochemical expression of P53 protein, usually occurs due to its accumulation because of p53 gene mutation, with consequent loss of its tumor-suppressing function 13 . Mutation mechanism is controversial, and studies indicate that the protein P53 participates in apoptosis, acting contrary to Bcl-2.…”

Section: P53mentioning

confidence: 99%

Respiratory immunohistochemical study in rats exposed to cigarette smoke and alcohol

et al. 2015

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PURPOSE:To investigate the effects of exposure to cigarette and alcohol on immunohistochemical disorders caused by these attacks to respiratory system of rats. METHODS:Sixty male Wistar rats in four groups: control, cigarette smoke, alcohol and cigarette smoke + alcohol during 260 days.Immunohistochemistry was performed by researching survivin and protein P53 expressions and apoptotic index in parenchymal lung and trachea using TUNEL technique. RESULTS:There was body growth impairment in all experimental groups. Both smoker groups animals had higher trachea survivin expression and bronchial higher apoptotic index. The trachea apoptotic index was also higher in the cigarette smoke group as well as in the alveoli in the cigarette smoke + alcohol group. The three experimental groups showed negative immunoexpression for P53. CONCLUSIONS: this model resulted in immunohistochemical changes caused mainly by exposure to cigarette smoke. There was a synergistic action between alcohol and tobacco in the growth impairment in animals as well as in the cellular apoptotic index. The positive immunoexpression for tracheal survivin in animals from both groups exposed to tobacco smoke and associated with a negative P53 immunoexpression suggests that despite the aggression, carcinogenesis has not happened yet. In addition, the bronchial higher apoptotic index in smokers may be responsible for emphysema.

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The Role of p53 in Cell Cycle Regulation

Cited by 113 publications

References 65 publications

Invasion of the cavernous sinus space in pituitary adenomas: endoscopic verification and its correlation with an MRI-based classification

Invasion of the cavernous sinus space in pituitary adenomas: endoscopic verification and its correlation with an MRI-based classification

Osteosarcoma: From Molecular Biology to Mesenchymal Stem Cells

Respiratory immunohistochemical study in rats exposed to cigarette smoke and alcohol

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