The Role of P53 and K-Ras in Regulating Spleen Innate Mediators in Mice with Colon Cancer

Hadad, Sahar El; Rowily, Eman Al; Aldahlawi, Alia; Alrahimi, Jehan; Hassoubah, Shahira

doi:10.51847/wlozfpcihr

Cited by 5 publications

(2 citation statements)

References 44 publications

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“…Splenomegaly that developed after abdominal radiotherapy for gastric cancer later resulted in sepsis, pneumonia, prolonged hospitalization, sepsis-related death, and increased economic burden for the patient [37]. It was also observed that splenectomy directly correlated with a significant increase in malignancy induction, as splenectomized rats and mice showed a significant increase in malignancy induction [38]. In an epidemiological study by Kristinsson et al increased risk of not only hematologic malignancies in splenectomized patients but also many solid tumors (lungs, cheek, esophagus, pancreas, liver, colon, and prostate) occur/was reported [39].…”

Section: Discussionmentioning

confidence: 97%

Exploring the Influence of the Selected Conjugated Fatty Acids Isomers and Cancerous Process on the Fatty Acids Profile of Spleen

Lepionka,

Białek,

Czauderna

et al. 2024

Cancers

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The spleen, traditionally associated with blood filtration and immune surveillance, has recently been recognized for its role in systemic lipid metabolism and potential influence on cancer development and progression. This study investigates effects of dietary supplements, specifically conjugated linolenic acids from pomegranate seed oil and bitter melon extract, on the fatty acid (FA) composition of the spleen in the context of cancerous processes. Advanced methods, including gas chromatography–mass spectrometry and silver ion-impregnated high-performance liquid chromatography, were employed to analyze the spleen’s FA profile. Our research uncovered that dietary supplementation leads to alterations in the spleen’s FA profile, especially under the carcinogenic influence of 7,12-dimethylbenz[a]anthracene. These changes did not align with a simple protective or anti-carcinogenic pattern, as previously suggested in in vitro studies. We observed shifts in conjugated FA isomer concentrations and variations in desaturase activities, suggesting disrupted lipid metabolism in cancerous conditions. The findings underscore the spleen’s vital role in lipid metabolism within the body’s systemic health framework, highlighting the complexity of dietary supplements’ impact on FA profiles in the spleen and their potential implications in cancer progression and treatment. This study adds valuable insight into the complex interplay between diet, disease, and metabolic regulation, particularly in cancerous environments.

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Section: Discussionmentioning

confidence: 97%

Exploring the Influence of the Selected Conjugated Fatty Acids Isomers and Cancerous Process on the Fatty Acids Profile of Spleen

Lepionka,

Białek,

Czauderna

et al. 2024

Cancers

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show abstract

“…Hypersplenism developing after abdominal radiotherapy in gastric carcinoma resulted later in numerous complications [8]. It was also observed that splenectomies correlated directly to a significant increase in malignant tumor induction, as splenectomized rats and mice showed a significant increase in malignant tumor induction [9]. Epidemiological studies by Kristinsson et al revealed an increased risk of numerous solid tumors (lung, buccal, esophagus, pancreas, liver, colon, and prostate) as well as hematologic malignancies in splenectomized patients [10].…”

Section: Introductionmentioning

confidence: 99%

Splenic Elemental Composition of Breast Cancer-Suffering Rats Supplemented with Pomegranate Seed Oil and Bitter Melon Extract

Białek,

Lepionka,

Wojtak

et al. 2024

Molecules

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The aim of this study was to investigate how dietary modifications with pomegranate seed oil (PSO) and bitter melon aqueous extract (BME) affect mineral content in the spleen of rats both under normal physiological conditions and with coexisting mammary tumorigenesis. The diet of Sprague-Dawley female rats was supplemented either with PSO or with BME, or with a combination for 21 weeks. A chemical carcinogen (7,12-dimethylbenz[a]anthracene) was applied intragastrically to induce mammary tumors. In the spleen of rats, the selected elements were determined with a quadrupole mass spectrometer with inductively coupled plasma ionization (ICP-MS). ANOVA was used to evaluate differences in elemental composition among experimental groups. Multivariate statistical methods were used to discover whether some subtle dependencies exist between experimental factors and thus influence the element content. Experimental factors affected the splenic levels of macroelements, except for potassium. Both diet modification and the cancerogenic process resulted in significant changes in the content of Fe, Se, Co, Cr, Ni, Al, Sr, Pb, Cd, B, and Tl in rat spleen. Chemometric analysis revealed the greatest impact of the ongoing carcinogenic process on the mineral composition of the spleen. The obtained results may contribute to a better understanding of peripheral immune organ functioning, especially during the neoplastic process, and thus may help develop anticancer prevention and treatment strategies.

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Maternal and Fetal Outcomes in Pregnancies Affected by Osteosarcoma of the Jaw: A Case Report

Mtenga,

Sohal,

Sohal

et al. 2023

Clin Cancer Investig J

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The Role of P53 and K-Ras in Regulating Spleen Innate Mediators in Mice with Colon Cancer

Cited by 5 publications

References 44 publications

Exploring the Influence of the Selected Conjugated Fatty Acids Isomers and Cancerous Process on the Fatty Acids Profile of Spleen

Exploring the Influence of the Selected Conjugated Fatty Acids Isomers and Cancerous Process on the Fatty Acids Profile of Spleen

Splenic Elemental Composition of Breast Cancer-Suffering Rats Supplemented with Pomegranate Seed Oil and Bitter Melon Extract

Maternal and Fetal Outcomes in Pregnancies Affected by Osteosarcoma of the Jaw: A Case Report

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