The Role of Oxidative Stress in Ovarian Cancer

White, Matthew L.; Cohen, Joshua G.; Hummel, Charles S.; Burky, Robert; Cruz, Ana Carla da; Farias‐Eisner, Robin

doi:10.1016/b978-0-12-405205-5.00005-2

Cited by 12 publications

(1 citation statement)

References 53 publications

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“…RONS levels peak during ovulation due to increased luteinizing hormone secretion that causes an increase in inflammatory precursors in the ovary, so that RONS levels act as important ovulation signals that mediate follicular wall rupture. A later decline in RONS concentration is related with a production of estrogens, which exert an antioxidant effect [11]. A crucial role of RONS in the ovarian function manifests in a multitude of ways, including their action as second messengers to control meiosis, cumulus expansion, ovulation, corpus luteum formation and regression as well as progesterone secretion [12].…”

Section: Introductionmentioning

confidence: 99%

Redox Biomarkers and Matrix Remodeling Molecules in Ovarian Cancer

Supruniuk,

Baczewska,

Żebrowska

et al. 2024

Antioxidants

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Ovarian cancer (OC) has emerged as the leading cause of death due to gynecological malignancies among women. Oxidative stress and metalloproteinases (MMPs) have been shown to influence signaling pathways and afflict the progression of carcinogenesis. Therefore, the assessment of matrix-remodeling and oxidative stress intensity can determine the degree of cellular injury and often the severity of redox-mediated chemoresistance. The study group comprised 27 patients with serous OC of which 18% were classified as Federation of Gynecology and Obstetrics (FIGO) stages I/II, while the rest were diagnosed grades III/IV. The control group comprised of 15 ovarian tissue samples. The results were compared with genetic data from The Cancer Genome Atlas. Nitro-oxidative stress, inflammation and apoptosis biomarkers were measured colorimetrically/fluorometrically or via real-time PCR in the primary ovarian tumor and healthy tissue. Stratification of patients according to FIGO stages revealed that high-grade carcinoma exhibited substantial alterations in redox balance, including the accumulation of protein glycoxidation and lipid peroxidation products. TCGA data demonstrated only limited prognostic usefulness of the studied genes. In conclusion, high-grade serous OC is associated with enhanced tissue oxidative/nitrosative stress and macromolecule damage that could not be overridden by the simultaneously augmented measures of antioxidant defense. Therefore, it can be assumed that tumor cells acquire adaptive mechanisms that enable them to withstand the potential toxic effects of elevated reactive oxygen species.

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Section: Introductionmentioning

confidence: 99%