The Role of Oxidative Stress and Inflammatory Parameters in Heart Failure

Abstract

Heart failure (HF) remains a major medical and social problem. The NT-pro-brain natriuretic peptide (NT-proBNP) and its active form, brain-type natriuretic peptide (BNP), in a simple blood test are the gold-standard biomarkers for HF diagnosis. However, even good biomarkers such as natriuretic peptides fail to predict all the risks associated with HF due to the diversity of the mechanisms involved. The pathophysiology of HF is determined by numerous factors, including oxidative stress, inflammation, neuroendocrine activation, pathological angiogenesis, changes in apoptotic pathways, fibrosis and vascular remodeling. High readmission and mortality rates prompt a search for new markers for the diagnosis, prognosis and treatment of HF. Oxidative-stress-mediated inflammation plays a crucial role in the development of subsequent changes in the failing heart and provides a new insight into this complex mechanism. Oxidative stress and inflammatory biomarkers appear to be a promising diagnostic and prognostic tool in patients with HF. This systematic review provides an overview of the current knowledge about oxidative stress and inflammation parameters as markers of HF.

Linking MDA Levels and Blood Glucose in Streptozotocin-Induced Rat Diabetes: Implications for Diabetic Complications and Therapeutic Strategies

“…Overall, these findings underscore the importance of monitoring MDA levels as a marker for oxidative stress and its potential implications in biological systems (Bencivenga et al, 2023;Wróbel-Nowicka et al, 2024;Kong et al, 2024;Valavanidis et al, 2006). Further research may delve into elucidating the specific factors contributing to the observed increase in MDA levels in the control (+) group, leading to a better understanding of the underlying mechanisms and potential therapeutic interventions to mitigate oxidative stress-related damage.…”