The role of oxidative stress and NADPH oxidase in cerebrovascular disease

Chrissobolis, Sophocles; Faraci, Frank M.

doi:10.1016/j.molmed.2008.09.003

Cited by 193 publications

(187 citation statements)

References 88 publications

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“…Activation of the NADPH oxidase has been linked as a major causative role in injured brain by generating reactive oxygen radicals. When it is activated, NADPH oxidase forms an active complex with several phox subunits, including p67 phox , which upon activation translocates to the membrane from the cytoplasm (22)(23)(24). We found that gp91 phox , a subunit of the NADPH oxidase complex that is constitutively expressed in microglia in the CNS (25), was up-regulated in the kernicteric brain.…”

Section: Alteration Of Redox Status and Activation Of Stress-responsementioning

confidence: 76%

Developmental Onset of Bilirubin-induced Neurotoxicity Involves Toll-like Receptor 2-dependent Signaling in Humanized UDP-glucuronosyltransferase1 Mice

Yueh

Chen

Nguyen

et al. 2014

Journal of Biological Chemistry

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Background: Neonatal jaundice with dangerously high levels of serum bilirubin leads to neurological toxicity. Results: Toll-like receptor 2 signaling is essential for regulation of glia activation, neuroinflammation, and oxidative stress when neonatal mice experience severe hyperbilirubinemia. Conclusion: Toll-like receptor 2 signaling is linked to a protection mode against serum bilirubin-induced brain toxicity. Significance: Understanding how signaling from innate immunity contributes to bilirubin-induced pathology.

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Section: Alteration Of Redox Status and Activation Of Stress-responsementioning

confidence: 76%

Developmental Onset of Bilirubin-induced Neurotoxicity Involves Toll-like Receptor 2-dependent Signaling in Humanized UDP-glucuronosyltransferase1 Mice

Yueh

Chen

Nguyen

et al. 2014

Journal of Biological Chemistry

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“…Thus far, the role of oxidative stress has been documented in the pathophysiology of numerous disorders. Cardio-and cerebrovascular diseases as well as diabetes mellitus are important examples of these disorders, whose prevalence are reaching near epidemic levels and thus regarded as public health concerns (Chrissobolis & Faraci, 2008;Lakshmi et al, 2009;Giacco & Brownlee, 2010).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activities of Juniperus foetidissima essential oils against several oxidative systems

Emami¹,

Asgary²,

Naderi³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The present study aimed to evaluate the antioxidant activity of essential oils obtained from branchlets of male and female trees as well as fruits of Juniperus foetidissima Willd., Cupressaceae, from Iran. For this purpose, essential oils of J. foetidissima were phytochemically analyzed and different concentrations of them were tested in five oxidative systems: 1) low-density lipoprotein oxidation; 2) linoleic acid peroxidation; 3) red blood cell hemolysis; 4) hemoglobin glycation; and 5) insulin glycation assays. In all employed systems, antioxidant effects were observed from the three tested oils though in varying degrees. The most promising activities of the oils were observed against hemoglobin and insulin glycation. Antioxidant activities of the oils did not appear to be dose-dependent. In addition, no consistent superiority in antioxidant effects was observed from a single oil in different assays. In view of the current results, J. foetidissima branchlet and fruit oils could be regarded as effective natural products with anti-glycation activity.

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“…The causes and impact of oxidative stress are a major focus in studies of vascular biology. Oxidative stress plays a fundamental role in cerebral vascular dysfunction in diverse models of disease, but little is known regarding its role in aging (5). The first goal of this study was to define the effect of age on the cerebral artery and to examine the hypothesis that age-related dysfunction is mediated by ROS.…”

mentioning

confidence: 99%

Role of oxidative stress and AT₁ receptors in cerebral vascular dysfunction with aging

Modrick

Didion²,

Sigmund³

et al. 2009

American Journal of Physiology-Heart and Circulatory Physiology

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114

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Vascular dysfunction occurs with aging. We hypothesized that oxidative stress and ANG II [acting via ANG II type 1 (AT 1) receptors] promotes cerebral vascular dysfunction with aging. We studied young (5-6 mo), old (17-19 mo), and very old (23 Ϯ 1 mo) mice. In basilar arteries in vitro, acetylcholine (an endothelium-dependent agonist) produced dilation in young wild-type mice that was reduced by ϳ60 and 90% (P Ͻ 0.05) in old and very old mice, respectively. Similar effects were seen using A23187, a second endothelium-dependent agonist. The vascular response to acetylcholine in very old mice was almost completely restored with tempol (a scavenger of superoxide) and partly restored by PJ34, an inhibitor of poly(ADP-ribose) polymerase (PARP). We used mice deficient in Mn-SOD (Mn-SOD ϩ/Ϫ ) to test whether this form of SOD protected during aging but found that age-induced endothelial dysfunction was not altered by Mn-SOD deficiency. Cerebral vascular responses were similar in young mice lacking AT 1 receptors (AT1 Ϫ/Ϫ ) and wild-type mice. Vascular responses to acetylcholine and A23187 were reduced by ϳ50% in old wild-type mice (P Ͻ 0.05) but were normal in old AT 1-deficient mice. Thus, aging produces marked endothelial dysfunction in the cerebral artery that is mediated by ROS, may involve the activation of PARP, but was not enhanced by Mn-SOD deficiency. Our findings suggest a novel and fundamental role for ANG II and AT 1 receptors in ageinduced vascular dysfunction. basilar artery; endothelium; genetically altered mice; acetylcholine; angiotensin II; A23187

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The role of oxidative stress and NADPH oxidase in cerebrovascular disease

Cited by 193 publications

References 88 publications

Developmental Onset of Bilirubin-induced Neurotoxicity Involves Toll-like Receptor 2-dependent Signaling in Humanized UDP-glucuronosyltransferase1 Mice

Developmental Onset of Bilirubin-induced Neurotoxicity Involves Toll-like Receptor 2-dependent Signaling in Humanized UDP-glucuronosyltransferase1 Mice

Antioxidant activities of Juniperus foetidissima essential oils against several oxidative systems

Role of oxidative stress and AT₁ receptors in cerebral vascular dysfunction with aging

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The role of oxidative stress and NADPH oxidase in cerebrovascular disease

Cited by 193 publications

References 88 publications

Developmental Onset of Bilirubin-induced Neurotoxicity Involves Toll-like Receptor 2-dependent Signaling in Humanized UDP-glucuronosyltransferase1 Mice

Developmental Onset of Bilirubin-induced Neurotoxicity Involves Toll-like Receptor 2-dependent Signaling in Humanized UDP-glucuronosyltransferase1 Mice

Antioxidant activities of Juniperus foetidissima essential oils against several oxidative systems

Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging

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Role of oxidative stress and AT₁ receptors in cerebral vascular dysfunction with aging