The Role of Oxidative Stress in Endometriosis

Mulgund, Aditi; Doshi, Sejal; Agarwal, Ashok

doi:10.1016/b978-0-12-800872-0.00025-1

Cited by 16 publications

(12 citation statements)

References 62 publications

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“…Or should retaining them in an environment of reduced ROS and mitigated epigenetic alterations be considered the optimal line of approach? Measurement of oxidative stress markers such as iron and nitric oxide could be employed as non-invasive diagnostic tools [ 37 ], therefore their identification should be prioritized by researchers [ 38 ]. Furthermore, the beneficial role of anti-oxidant agents in the prevention and treatment of endometriosis should be further explored [ 37 ], while clinical trials are required to determine their efficiency [ 17 ].…”

Section: Reactive Oxygen Species (Ros)mentioning

confidence: 99%

“…Measurement of oxidative stress markers such as iron and nitric oxide could be employed as non-invasive diagnostic tools [ 37 ], therefore their identification should be prioritized by researchers [ 38 ]. Furthermore, the beneficial role of anti-oxidant agents in the prevention and treatment of endometriosis should be further explored [ 37 ], while clinical trials are required to determine their efficiency [ 17 ]. Overall, thorough investigations of how oxidative stress intertwines with endometriosis-related infertility remain to be conducted and communicated back to the practitioner.…”

Section: Reactive Oxygen Species (Ros)mentioning

confidence: 99%

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Getting to Know Endometriosis-Related Infertility Better: A Review on How Endometriosis Affects Oocyte Quality and Embryo Development

et al. 2021

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Endometriosis-related infertility describes a case of deteriorated fecundity when endometriosis is diagnosed. Numerous mechanisms have been proposed in an effort to delineate the multifaceted pathophysiology that induces impairment of reproductive dynamics in patients with endometriosis. In this critical analysis, authors present the plethora of molecular events that are entailed and elaborate on how they potentially impair the oocyte’s and embryo’s competence in patients with endometriosis. Reactive oxygen species, dysregulation of the immune system and cellular architectural disruption constitute the crucial mechanisms that detrimentally affect oocyte and embryo developmental potential. The molecular level impairment of the reproductive tissue is discussed, since differentiation, proliferation and apoptosis constitute focal regulatory cellular functions that appear severely compromised in cases of endometriosis. Mapping the precise molecular mechanisms entailed in endometriosis-related infertility may help delineate the complex nature of the disorder and bring us a step closer to a more personalized approach in understanding, diagnosing and managing endometriosis-related infertility.

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Section: Reactive Oxygen Species (Ros)mentioning

confidence: 99%

Section: Reactive Oxygen Species (Ros)mentioning

confidence: 99%

Getting to Know Endometriosis-Related Infertility Better: A Review on How Endometriosis Affects Oocyte Quality and Embryo Development

et al. 2021

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“…Structurally, catalase is a tetrameric haem protein and it is mostly present in peroxisomes [80]. By contrast, glutathione peroxidase is a cytosolic antioxidant enzyme that acts against a wider variety of peroxides, as it plays major roles in preventing lipid peroxidation and maintaining the intracellular homeostasis and redox balance [75,81]. After reducing hydrogen peroxide, the oxidized glutathione further oxidizes thiol groups in proteins [71].…”

Section: Antioxidant Defense Mechanismmentioning

confidence: 99%

Antioxidant Therapies for Neuroprotection—A Review

Teleanu

Chircov

Grumezescu

et al. 2019

JCM

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Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between the production and accumulation of ROS and the ability of the body to neutralize and eliminate them. In the brain, oxidative stress exhibits significant effects, due to its increased metabolical activity and limited cellular regeneration. Thus, oxidative stress is a major factor in the progressive loss of neurons structures and functions, leading to the development of severe neurodegenerative disorders. In this context, recent years have witnessed tremendous advancements in the field of antioxidant therapies, with a special emphasis for neuroprotection. The aim of this paper is to provide an overview of the oxidative stress and antioxidant defense mechanisms and to present the most recent studies on antioxidant therapies for neuroprotection.

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“…25,26 Many studies widely accepted that oxidative stress might be implicated in the pathophysiology of endometriosis causing a general inflammatory response in the peritoneal cavity. [27][28][29][30][31] It is not known exactly how endometriosis causes infertility, but it is probably related to the inflammatory response resulting from the overproduction of prostaglandins, cytokines and macrophages, and natural killer cells. The inflammatory process thus impairs the function of the ovaries, peritoneal system, fallopian tubes, and endometrium and leads to impaired folliculogenesis, fertilization, and other conditions.…”

Section: Introductionmentioning

confidence: 99%

Antimüllerian Hormone and Oxidative Stress Biomarkers as Predictors of Successful Pregnancy in Polycystic Ovary Syndrome, Endometriosis and Tubal Infertility Factor

Fabjan¹,

VrtaÄŤnik-Bokal²,

Virant‐Klun³

et al. 2020

ACSi

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Oxidative stress in the follicular fluid (FF) is thought to be responsible for the abnormal development of oocytes. In our study patients with polycystic ovarian syndrome (PCOS), endometriosis, and tubal infertility factor (TIF), and healthy women with a male factor of infertility, were prospectively enrolled. From each patient, a sample of individual FF was collected from a dominant follicle. Concentration levels of TAS, 8-IP, 8-OHdG, and AMH were determined. In women with PCOS, we found significantly lower values of oxidative stress markers in the FF. 8-IP and TAS levels were lower in the FF of women with endometriosis. In women with TIF, we also found significantly lower values of all tested markers in the FF, except for 8-OHdG and AMH. We wanted to see whether the biomarker measured in the FF in an individual diagnosis could predict a successfully obtained embryo from this particular follicle. The FF 8-OHdG result in PCOS patients stood out and proved to be a good predictive marker of matured and fertilized oocytes in these patients. Further research is needed to be able to apply the acquired knowledge in improving the outcome of IVF procedures.

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The Role of Oxidative Stress in Endometriosis

Cited by 16 publications

References 62 publications

Getting to Know Endometriosis-Related Infertility Better: A Review on How Endometriosis Affects Oocyte Quality and Embryo Development

Getting to Know Endometriosis-Related Infertility Better: A Review on How Endometriosis Affects Oocyte Quality and Embryo Development

Antioxidant Therapies for Neuroprotection—A Review

Antimüllerian Hormone and Oxidative Stress Biomarkers as Predictors of Successful Pregnancy in Polycystic Ovary Syndrome, Endometriosis and Tubal Infertility Factor

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