The role of oxidation and enzymatic hydrolysis on the in vivo degradation of trimethylene carbonate based photocrosslinkable elastomers

Chapanian, Rafi; Tse, M. Yat; Pang, Stephen C.; Amsden, Brian G.

doi:10.1016/j.biomaterials.2008.09.038

Cited by 87 publications

(126 citation statements)

References 28 publications

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“…The degradation of PTMC in vivo produced alcohol and carbon dioxide, which did not reduce the pH at the interface between the hydrogel and the tissue. [71] ABA-type block copolymers consisting of poly(propylene fumarate) (PPF) and MPEG were synthesized by a simple transesterification method. [72] The triblock copolymer with MPEG molecular weights of 570 and 800 in aqueous solution exhibited a thermosensitive gelation process in the concentration range of 5-25 wt.-%.…”

Section: Other Thermosensitive Block Copolymersmentioning

confidence: 99%

Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

416

343

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Injectable biodegradable copolymer hydrogels, which exhibit a sol–gel phase transition in response to external stimuli, such as temperature changes or both pH and temperature (pH/temperature) alterations, have found a number of uses in biomedical and pharmaceutical applications, such as drug delivery, cell growth, and tissue engineering. These hydrogels can be used in simple pharmaceutical formulations that can be prepared by mixing the hydrogel with drugs, proteins, or cells. Such formulations are administered in a straightforward manner, through site‐specific control of release behavior, and the hydrogels are compatible with biological systems. This review will provide a summary of recent progress in biodegradable temperature‐sensitive polymers including polyesters, polyphosphazenes, polypeptides, and chitosan, and pH/temperature‐sensitive polymers such as sulfamethazine‐, poly(β‐amino ester)‐, poly(amino urethane)‐, and poly(amidoamine)‐based polymers. The advantages of pH/temperature‐sensitive polymers over simple temperature‐sensitive polymers are also discussed. A perspective on the future of injectable biodegradable hydrogels is offered.magnified image

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Section: Other Thermosensitive Block Copolymersmentioning

confidence: 99%

Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

416

343

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“…Oxidation by reactive oxygen compounds secreted by macrophages is considered to be the main cause of degradation of polycarbonates in vivo. [27,28,32,33] Low Viscosity Poly(trimethylene carbonate) for Localized Drug Delivery . .…”

Section: In Vivo Degradationmentioning

confidence: 99%

Low Viscosity Poly(trimethylene carbonate) for Localized Drug Delivery: Rheological Properties and in vivo Degradation

Timbart

Tse

Pang

et al. 2009

Macromolecular Bioscience

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The purpose of this study is to examine the potential of low-molecular-weight poly(trimethylene carbonate) for localized delivery for acid-sensitive drugs. Poly(trimethylene carbonate) of various molecular weights is prepared by ring-opening polymerization initiated by octan-1-ol and co-initiated/catalyzed by tin 2-ethylhexanoate. The resultant polymers are amorphous with low glass transition temperatures and viscosities at 37 degrees C that permit their injection through an 18(1\2) G 1.5'' needle. Their biocompatibility and the influence of the molecular weight on the rate of degradation are assessed in vivo through subcutaneous implantation in rats over 40 weeks. The polymers are well tolerated in vivo, and degrade in a fashion dependent on their initial molecular weight. For very low initial molecular weight (620 Da) and for high initial molecular weight (2,400 Da), polymer mass loss is a result of dissolution of the soluble low molecular chains from the bulk. This is contrasted by the results obtained for an intermediate initial molecular weight (1,600 Da), for which polymer mass loss is a result of both dissolution and enzymatic hydrolysis or oxidation as a result of reactive species secreted by activated macrophages at the implant surface.

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“…[65, [95][96][97] PTMC based polymers and networks degrade by an enzymatic surface erosion mechanism, without the release of acidic degradation products. [65,[98][99][100] In vivo, linear high molecular weight PTMC films were found to degrade in 3 weeks.…”

Section: Tissue Engineeringmentioning

confidence: 99%

“…PTMC networks prepared by photo-crosslinking acrylate end-capped PTMC macromers with molecular weight=7300 g/mol, showed a mass loss of 33 % after 44 weeks under the same conditions. [95] This implies that these dense networks degrade at even slower rates than the ones obtained by gamma-irradiation. The degradation rates of linear polytrimethylene carbonate polymers and networks can be further tuned by copolymerization of trimethylene carbonate with -caprolactone or D,L-lactide.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Advanced microstructures based on poly(trimethylene carbonate) : microfabrication and stereolithography

Schüller-Ravoo¹

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The role of oxidation and enzymatic hydrolysis on the in vivo degradation of trimethylene carbonate based photocrosslinkable elastomers

Cited by 87 publications

References 28 publications

Injectable Biodegradable Hydrogels

Injectable Biodegradable Hydrogels

Low Viscosity Poly(trimethylene carbonate) for Localized Drug Delivery: Rheological Properties and in vivo Degradation

Advanced microstructures based on poly(trimethylene carbonate) : microfabrication and stereolithography

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