The role of ovarian steroids in affective disorders

Wei, Shau-Ming; Schiller, Crystal Edler; Schmidt, Peter J.; Rubinow, David R.

doi:10.1016/j.cobeha.2018.04.013

Cited by 21 publications

(20 citation statements)

References 69 publications

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“…The scope of this article is limited to the basics needed to initiate clinical practice and research work in this area. Especially interested readers can complement this primer with other in-depth epidemiological and methodological reviews (Eisenlohr-Moul et al, 2017;Hantsoo & Epperson, 2015;Schiller, Johnson, Abate, Schmidt, & Rubinow, 2016;Wei, Schiller, Schmidt, & Rubinow, 2018).…”

Section: Premenstrual Disorders 2 Premenstrual Disorders: a Primer Anmentioning

confidence: 99%

“…Several lines of investigation are focused on altered luteal phase serotonergic function in PMDD (Roca et al, 2002), altered function of the GABA-A receptor and its response to GABAergic progesterone metabolites (MacKenzie & Maguire, 2014;Martinez et al, 2016), and, most recently, altered cellular gene expression relevant to hormone processing (Dubey et al, 2017). Several expert, up-to-date reviews are available for those who wish to read further about the state of the knowledge in this small but growing area (Schiller et al, 2016;Wei et al, 2018). However, for the purposes of this primer, the critical point is that PMDD is caused by an abnormal neurobiological sensitivity to normal hormone changes across the menstrual cycle, and not abnormal or disordered reproductive hormones or function.…”

Section: Biological Mechanisms Of Pmddmentioning

confidence: 99%

“…Clarifying Biological Underpinnings of PMDs. The pathophysiology of PMDs (mostly PMDD) is a small but rigorous area of neurobiological research, historically carried out primarily by a few psychiatrists and behavioral scientists without clinical training (Wei et al, 2018).…”

Section: Critical Research Areas In Pmdsmentioning

confidence: 99%

“…These facts alone are sufficient to recommend that all psychotherapists receive some rudimentary training in the menstrual cycle and PMDs; however, clinical psychology and other psychotherapy training programs do not yet provide training in this area. There have been good reasons for caution around these issues in the past, such as a concern about stigmatizing or disempowering females and a lack of empirical evidence about the scope of PMDs (Hartlage et al, 2014); however, given the strong experimental evidence for individual differences in hormone sensitivity that has accumulated over the past 30 years (Wei et al, 2018)…”

Section: Psychotherapy Patients As a Group At Risk For Pmdsmentioning

confidence: 99%

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Premenstrual Disorders: A Primer and Research Agenda for Psychologists

Eisenlohr‐Moul

2019

Preprint

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Females are two times more likely to develop an affective disorder and three times more likely to make a suicide attempt. The etiology of these sex differences is complex, and cannot be reduced to biology alone. However, the growing field of reproductive mood disorders highlights how lifetime exposure to fluctuations in neuroactive sex hormones (including across the menstrual cycle) do contribute to greater female risk, specifically among those females who are neurobiologically sensitive to normal hormone changes (e.g., those with premenstrual disorders). Psychologists--and particularly clinical psychologists-- are trained to be expert in skills relevant to the study and treatment of premenstrual disorders, including assessment, differential diagnosis, and mechanisms of complex behaviors, and often develop other relevant expertise in the neurobiology of affective disorders and advanced longitudinal methods. The purpose of this article is to clarify how psychologists’ strengths can be readily applied to advance scientific knowledge and improve patient care in premenstrual disorders. In order to increase psychologist involvement in this emerging field, this article includes a primer on premenstrual disorders such as premenstrual dysphoric disorder (PMDD) and premenstrual exacerbation (PME) of underlying disorders. It then provides recommendations for research psychologists interested in engaging this field, and outlines critical research areas for future work. Finally, brief recommendations for psychologists in clinical practice are provided.

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Section: Premenstrual Disorders 2 Premenstrual Disorders: a Primer Anmentioning

confidence: 99%

Section: Biological Mechanisms Of Pmddmentioning

confidence: 99%

Section: Critical Research Areas In Pmdsmentioning

confidence: 99%

Section: Psychotherapy Patients As a Group At Risk For Pmdsmentioning

confidence: 99%

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Premenstrual Disorders: A Primer and Research Agenda for Psychologists

Eisenlohr‐Moul

2019

Preprint

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“…Several neuroimaging studies have suggested a neurofunctional basis for hormonally-related behavioral phenomena (for review see refs. 7 , 8 ). In PMDD, the luteal (symptomatic) phase of the menstrual cycle has been associated with altered task-related activations in the medial and lateral orbitofrontal cortex (OFC), amygdala 9 , dorsolateral prefrontal cortex (DLPFC) 10 , insula and medial prefrontal cortex 11 , 12 .…”

Section: Introductionmentioning

confidence: 99%

Subgenual cingulate resting regional cerebral blood flow in premenstrual dysphoric disorder: differential regulation by ovarian steroids and preliminary evidence for an association with expression of ESC/E(Z) complex genes

Wei

Baller

Martinez³

et al. 2021

Transl Psychiatry

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Substantial evidence suggests that circulating ovarian steroids modulate behavior differently in women with PMDD than in those without this condition. However, hormonal state-related abnormalities of neural functioning in PMDD remain to be better characterized. In addition, while altered neural function in PMDD likely co-exists with alterations in intrinsic cellular function, such a relationship has not been explored. Here, we investigated the effects of ovarian steroids on basal, resting regional cerebral blood flow (rCBF) in PMDD, and, in an exploratory analysis, we tested whether the rCBF findings were linked to the expression of ESC/E(Z) genes, which form an essential ovarian steroid-regulated gene-silencing complex. Resting rCBF was measured with oxygen-15 water PET (189 PET sessions in 43 healthy women and 20 women with PMDD) during three self-as-own-control conditions: GnRH agonist (Lupron)-induced ovarian suppression, estradiol add-back, and progesterone add-back. ESC/E(Z) gene expression data were obtained from RNA-sequencing of lymphoblastoid cell lines performed in a previous study and were examined in relation to hormone-induced changes in rCBF. In the rCBF PET data, there was a significant diagnosis-by-hormone interaction in the subgenual cingulate (PFDR = 0.05), an important neuroanatomical hub for regulating affective state. Whereas control women showed no hormonally-related changes in resting rCBF, those with PMDD showed decreased resting rCBF during both estradiol (P = 0.02) and progesterone (P = 0.0002) add-back conditions. In addition, in PMDD, ESC/E(Z) gene expression correlated with the change in resting rCBF between Lupron-alone and progesterone conditions (Pearson r = −0.807, P = 0.016). This work offers a formulation of PMDD that integrates behavioral, neural circuit, and cellular mechanisms, and may provide new targets for future therapeutic interventions.

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Premenstrual exacerbation of mental health disorders: a systematic review of prospective studies

Nolan

Hughes

2022

Arch Womens Ment Health

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The role of ovarian steroids in affective disorders

Cited by 21 publications

References 69 publications

Premenstrual Disorders: A Primer and Research Agenda for Psychologists

Premenstrual Disorders: A Primer and Research Agenda for Psychologists

Subgenual cingulate resting regional cerebral blood flow in premenstrual dysphoric disorder: differential regulation by ovarian steroids and preliminary evidence for an association with expression of ESC/E(Z) complex genes

Premenstrual exacerbation of mental health disorders: a systematic review of prospective studies

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