The role of osteopontin in the progression of solid organ tumour

Abstract

Osteopontin (OPN) is a bone sialoprotein involved in osteoclast attachment to mineralised bone matrix, as well as being a bone matrix protein, OPN is also a versatile protein that acts on various receptors which are associated with different signalling pathways implicated in cancer. OPN mediates various biological events involving the immune system and the vascular system; the protein plays a role in processes such as immune response, cell adhesion and migration, and tumorigenesis. This review discusses the potential role of OPN in tumour cell proliferation, angiogenesis and metastasis, as well as the molecular mechanisms involved in these processes in different cancers, including brain, lung, kidney, liver, bladder, breast, oesophageal, gastric, colon, pancreatic, prostate and ovarian cancers. The understanding of OPN’s role in tumour development and progression could potentially influence cancer therapy and contribute to the development of novel anti-tumour treatments.

Linking NRP2 With EMT and Chemoradioresistance in Bladder Cancer

“…The SPP1 gene (Osteopontin, OPN) was previously reported to be induced by VEGF (25) and to be associated with decreased survival, disease stage, and grading in BCa (26,27). Previous findings support the role of SPP1 as one of the key EMT regulators (28). We applied an EMT PCR array to analyze if SPP1 regulates gene expression of EMT regulators in our cell models.…”

Liver Matrix in Benign and Malignant Biliary Tract Disease

“…Overexpression of OPN has been observed in several carcinomas associated with an intense stroma, such as breast, prostate, lung, stomach, pancreatic and colorectal cancer, with prognostic significance especially in breast and lung cancer. 39,92 Thanks to its secretory properties, OPN can be also detected in biological fluids, including plasma, and thus used as tumor biomarker to monitor disease progression. In a recent translational study, increased serum levels of OPN discriminated patients with CCA from patients with PSC, and high OPN in pre-and postoperative settings was strongly associated with poor survival after resection.…”

<p>Blood Biomarkers of Uveal Melanoma: Current Perspectives</p>

“…32 This protein has been described in the context of various physiological functions, including chemotaxis, cell migration, cell adhesion, angiogenesis, apoptosis, extracellular cell-matrix interactions, immune regulation, and tumor metastasis. 33 Thus, it was shown that osteopontin actively promotes a tumorigenic phenotype and contributes to metastasis. 34 Increased osteopontin expression is associated with aggressive behavior and metastasis in breast, colon, prostate, lung, liver, and ovarian cancers.…”