The Role of Osteobiologics in Spinal Deformity

Cheng, Ivan; Oshtory, Rayshad; Wildstein, Michael

doi:10.1016/j.nec.2007.01.002

Cited by 6 publications

(3 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bone graft substitutes are commonly used to extend the volume of available autogenous bone harvested in major reconstructive spine procedures ( 7 , 15 ). While ceramic-based osteoconductive scaffolds account for a majority of the synthetic bone substitute materials, it is unclear whether inorganic mineral is essential for – or contributes favorably to – bone formation.…”

Section: Discussionmentioning

confidence: 99%

Within Patient Radiological Comparative Analysis of the Performance of Two Bone Graft Extenders Utilized in Posterolateral Lumbar Fusion: A Retrospective Case Series

Stewart

Gage

Neidert³

et al. 2016

Front. Surg.

View full text Add to dashboard Cite

Two bone graft extenders differing in chemical composition were implanted contralaterally in 27 consecutive patients undergoing instrumented posterolateral lumbar fusion as standard-of-care. Bone marrow aspirate and autogenous bone graft were equally combined either with β-tricalcium phosphate (β-TCP) or a hybrid biomaterial [containing hyaluronic acid (HyA) but lacking a calcium salt] and implanted between the transverse processes. Fusion status on each side of the vertebrae was retrospectively graded (1–5 scale) on AP planar X-ray at multiple visits as available, through approximately 12 months. Additionally, consolidation or resorption since prior visit for each treatment was recorded. Sides receiving β-TCP extender showed marked resorption prior to bone consolidation during the first 6 months. By contrast, sides receiving the hybrid biomaterial containing integrated HyA showed rapid bone consolidation by week 6–8, with maintenance of initial bone volume through 12 months. Fusion grade was superior for the hybrid biomaterial, differing significantly from β-TCP at day 109 and beyond. Fusion success at >12 months was 92.9 vs. 67.9% for the hybrid biomaterial and β-TCP-treated sides, respectively. The hybrid biomaterial extender demonstrated a shortened time-to-fusion compared to the calcium-based graft. Mode of action has been demonstrated in the literature to differ between these compositions. Therefore, choice of synthetic biomaterial composition may significantly influence the mode of action of cellular events regulating appositional bone growth.

show abstract

Section: Discussionmentioning

confidence: 99%

Within Patient Radiological Comparative Analysis of the Performance of Two Bone Graft Extenders Utilized in Posterolateral Lumbar Fusion: A Retrospective Case Series

Stewart

Gage

Neidert³

et al. 2016

Front. Surg.

View full text Add to dashboard Cite

show abstract

“…The intensity of the immune response that occurs depends on the degree of enzymatic degradation of the native allograft protein. Human allograft is available in two forms: mineralised and demineralised [17][18][19]. Among the mineralised allograft, freeze-dried allograft is processed by removing water by a vacuum process and is less immunogenic.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, allograft with or without demineralised bone matrix (DBM) have been recently used for ACDF and have achieved satisfactory clinical and radiological outcomes [15,16]. However, allograft and DBM also have several disadvantages, such as risk of disease transmission and immune reaction [17][18][19]. Moreover, the incidence of postoperative infection after ACDF is reported to be higher in allograft compared to that of autograft [11].…”

Section: Introductionmentioning

confidence: 99%

Postoperative changes of early-phase inflammatory indices after uncomplicated anterior cervical discectomy and fusion using allograft and demineralised bone matrix

Kong

Kim

Park

2012

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

Purposes We investigated sequential levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in uncomplicated ACDF (anterior cervical discectomy and fusion) using allograft and DBM (demineralised bone matrix) for primary cervical spondylosis and/or disc herniation. To our knowledge, there has been no study to investigate the diagnostic value of CRP and ESR for postoperative infection in ACDF using allograft and DBM. Methods Blood samples of 85 patients, who underwent one-(n 051) or two-level (n 034) ACDF, were obtained and evaluated before surgery and on the first, third, fifth, seventh, 14th, 30th, and 90th postoperative days. No infection was found in any patient for at least one year follow-up period. Results Mean CRP value increased significantly on the first postoperative day and reached a peak on the third postoperative day. The peak level rapidly decreased but remained elevated on the fifth, seventh, and 14th postoperative days. Mean ESR value increased significantly and reached a peak on the third postoperative day. The peak level gradually decreased but remained elevated on the fifth and seventh postoperative days. One-and two-level ACDF exhibited similar postoperative changes in CRP and ESR values and no significant difference in mean levels of CRP and ESR throughout the follow-up periods. Conclusions This study demonstrates that uncomplicated ACDF using allograft and DBM showed significant abnormal values of CRP and ESR during the early postoperative period. This result suggests that abnormal values of CRP and ESR in the early postoperative period do not indicate acute postoperative infection after ACDF using allograft and DBM. Straying from the normal course, such as a second rise or a failure to decrease, of CRP and ESR is more important to signpost acute postoperative infection in ACDF using allograft and DBM.

show abstract

Bone Graft and Bone Substitute Biology

Singh

Levi

2013

Spine Surgery Basics

View full text Add to dashboard Cite

The Role of Osteobiologics in Spinal Deformity

Cited by 6 publications

References 46 publications

Within Patient Radiological Comparative Analysis of the Performance of Two Bone Graft Extenders Utilized in Posterolateral Lumbar Fusion: A Retrospective Case Series

Within Patient Radiological Comparative Analysis of the Performance of Two Bone Graft Extenders Utilized in Posterolateral Lumbar Fusion: A Retrospective Case Series

Postoperative changes of early-phase inflammatory indices after uncomplicated anterior cervical discectomy and fusion using allograft and demineralised bone matrix

Bone Graft and Bone Substitute Biology

Contact Info

Product

Resources

About