The Role of Optical Coherence Tomography Angiography in Ranibizumab-Treated Choroidal Neovascularization in Choroidal Osteoma

Abstract

In this study, we report the initial evaluation of choroidal neovascularization (CNV) secondary to choroidal osteoma and subsequent response to anti-vascular endothelial growth factor (anti-VEGF) treatment monitored with optical coherence tomography angiography (OCT-A). A 38-year-old female presented with an initial visual acuity of 20/150 in the left eye. Clinical examination revealed a choroidal osteoma. OCT demonstrated both subretinal and intraretinal fluid. OCT-A was performed and showed CNV. A course of ten treatments with ranibizumab showed an improvement of visual acuity to 20/30-3, improvement of subretinal and intraretinal fluid, as well as attenuation of CNV. Our report demonstrates OCT-A as a useful tool for both initial evaluation of CNV and following treatment response to anti-VEGF therapy.

Choroidal Osteoma with Choroidal Neo Vascular Membrane

“…A high-quality OCT-A has proven to be a useful, noninvasive and cost-effective imaging method for detecting and monitoring treatment response of CNVM in Choroidal osteoma. 9 Treatment modalities available for CNVM are laser photocoagulation, photodynamic therapy and anti-vascular endothelial growth factor (VEGF). 10 Intravitreal anti VEGF is an effective therapeutic option for choroidal osteoma-associated CNVM, particularly when the CNVM is juxta foveolar or sub foveolar in location.…”