The Role of Open Lung Biopsy in the Management and Outcome of Patients With Diffuse Lung Disease

Kramer, Mordechai R.; Berkman, Neville; Mintz, Bella; Godfrey, Simon; Sauté, Milton; Amir, Gail

doi:10.1016/s0003-4975(97)01081-3

Cited by 110 publications

(84 citation statements)

References 17 publications

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“…[21] In the literature, median postoperative duration of hospital stay were reported as four days, with a range of 2 to 10 days. [23,29] In line with the literature, the median duration of hospital stay was two days in the present study.…”

Section: Discussionsupporting

confidence: 89%

Surgical lung biopsy for differential diagnosis of interstitial lung disease

Sevim¹

2016

Turk Gogus Kalp Dama

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So nuç: Cerrahi akciğer biyopsileri, düşük olasılıkla da olsa, morbidite ve mortalite ile ilişkilidir. Tüm işlemlerde spesifik tanıya ulaşılamamaktadır. Cerrahi biyopsinin yeri, tipi ve sayısı tanı oranını anlamlı olarak etkilememektedir.Anah tar söz cük ler: İdyopatik interstisyel pnömoni; idyopatik pulmoner fibrozis; nonspesifik interstisyel pnömoni. ABSTRACTBackground: This study aims to investigate the diagnostic yield of surgical lung biopsy for the differential diagnosis of interstitial lung disease and the factors affecting diagnosis.

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Section: Discussionsupporting

confidence: 89%

Surgical lung biopsy for differential diagnosis of interstitial lung disease

Sevim¹

2016

Turk Gogus Kalp Dama

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“…15,16 Clinical implications of these biopsies have been greatly exploited, mostly concerning their contribution to the determination of prognosis through therapeutic changes, but also because such surgical biopsied can be carried out with relatively low morbidity and frequently promote changes in treatment. [17][18][19][20] Clearly, most of the studies concerning surgical lung biopsies take into account only diagnostic information provided by routine histological analysis, usually regarded as the gold standard for clinical hypotheses in diffuse infiltrates, 21 in addition to clinical data. Histopathological data from surgical lung biopsies have rarely been exploited in detail.…”

Section: Discussionmentioning

confidence: 99%

Semiquantitative Assessment of Surgical Lung Biopsy: Predictive Value and Impact on Survival of Patients With Diffuse Pulmonary Infiltrate

Canzian

Soeiro

Taga

et al. 2007

Clinics

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. Semiquantitative assessment of surgical lung biopsy: predictive value and impact on survival of patients with diffuse pulmonary infiltrate. Clinics. 2007; 62(1):23-30.PURPOSE: Surgical lung biopsy has been studied in distinct populations, mostly going beyond clinical issues to impinge upon routine histopathological diagnostic information in diffuse infiltrates; however, detailed tissue analyses have rarely been performed. The present study was designed to investigate the prognostic contribution provided by detailed tissue analysis in diffuse infiltrates. METHODS: Medical records and surgical lung biopsies from the period of 1982 to 2003 of 63 patients older than 18 years with diffuse infiltrates were retrospectively examined. Lung parenchyma was histologically divided into 4 anatomical compartments: interstitium, airways, vessels, and alveolar spaces. Histological changes throughout these anatomical compartments were then evaluated according to their acute or chronic evolutional character. A semiquantitative scoring system was applied to histologic findings to evaluate the intensity and extent of the pathological process. We applied logistic regression to predict the risk of death associated with acute and chronic histological changes and to estimate the odds ratios for each of the independent variables in the model. RESULTS: Impact on survival was found for male gender (P = 0.03), presence of diffuse alveolar damage (P = 0.001), and chronic histological changes (P = 0.0004) on biopsy. Thus, being male was associated with a slightly lower risk (O.R. = 0.18; P=0.03) of dying than being female. Death risk was increased 17 times in the presence of acute histological changes such as diffuse alveolar damage and 2.5 times in the presence of chronic histological changes. CONCLUSION: Detailed analysis of histological specimens can provide more than a nosological diagnosis: this approach can provide valuable information concerning prognosis.

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“…Few studies have addressed the indications or diagnostic utility of lung biopsy in chILD syndrome ( Figure 6). Nevertheless, it is widely accepted that the potential benefits of lung biopsy outweigh the risks in most children with acute respiratory deterioration, prolonged lung disease, or unresolved lung disease (116)(117)(118)(119)(120)(121)(122)(123), particularly infants and young children on extracorporeal membrane oxygenation (124)(125)(126).…”

Section: Diagnostic Testsmentioning

confidence: 99%