The role of oligohydramnios and fetal growth restriction in adverse pregnancy outcomes in preeclamptic patients

Özgen, Gülten; Çakmak, Burcu Dinçgez; Özgen, Levent; Uguz, Seren; Sager, Hakan

doi:10.5603/gp.a2021.0094

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…However, the greatest challenges that lie ahead are in monitoring gestation and deciding whether to terminate pregnancy in women demonstrating the various clinical forms of placental insufficiency [10]. My belief is that a combination of the traditional physical examination methods such as blood pressure measurement, cardiotocography, ultrasound, and amniotic fluid volume assessment [11] with modern methods for assessing placental function will be crucial in ensuring proper management. This new definition of placental insufficiency that accounts for its varied severity pertains to nearly 10% of all pregnancies.…”

Section: Pomeranian Medical University In Szczecin Polandmentioning

confidence: 99%

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Kwiatkowski

2022

Ginekol Pol

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Section: Pomeranian Medical University In Szczecin Polandmentioning

confidence: 99%

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Kwiatkowski

2022

Ginekol Pol

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“…Preeclampsia is a complex multifactor and multisystem disease, which can be accompanied by diseases such as fetal growth restriction in utero, premature delivery and placental abruption. It can seriously affect the prognosis of pregnant women and fetuses, and even lead to long-term complications in women and newborns [2], and its pathophysiological mechanism remains unclear. Current studies suggest that abnormal placental growth caused by trophoblastic dysfunction.…”

Section: Introductionmentioning

confidence: 99%

A Review of the Studies on Placental Mesenchymal Stem Cells and Their Exosomes Applied to Preeclampsia

2024

medsc

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Preeclampsia (PE) is a complex complication of pregnancy, which is a major cause of maternal and neonatal mortality. Its pathogenesis is closely associated with placental defects, although the specific mechanisms remain unknown, and specific targeted therapeutic interventions are currently unavailable. This article reviews recent domestic and international literature on PE and reveals the differences in placental mesenchymal stem cells (PMSCs) between PE and normal pregnancy groups. PMSCs play a crucial role in intercellular communication, regulating the normal functions of cells and organs, including maintaining a healthy pregnancy. The pathogenesis of PE is intricately linked to PMSCs, and abnormalities in these cells are associated with oxidative stress, inflammation, vascular endothelial damage and placental anomalies. Recent research on exosomes offers the potential for treatment strategies for PE. This article provides a comprehensive overview of the role of PMSCs and their exosomes in the pathogenesis of PE, while also delving into their potential utility in the prognosis and management of this distinctive pregnancy-related ailment presenting invaluable perspectives for forthcoming investigations within this domain of scholarly inquiry.

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“…FGR affects 8% of pregnancies and 30% of stillbirths [2]. Around 3-6% of pregnant women get preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

Different clinical presentation of two pregnancy syndromes: Similar pro and antiangiogenic characteristics near delivery: Fetal growth preeclampsia

Raman

Prasad²,

Vishwanath³

2023

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This research aimed to determine if there was a statistically significant distinction between the serum anti- but also pro-angiogenic chemical ratios among pregnant women having preeclampsia and/or fetal growth limitation, two clinical subgroups of placental ischemia syndrome. We conducted a prospective case-control study that looked at 77 singleton pregnancies and compared them with and without preeclampsia with 77 singleton pregnancies with and without healthy fetuses, matching for gestational age. All pregnant participants in the trial were analyzed to determine the presence or absence of adverse outcomes. Because once in comparison to the control group, the study participants had higher levels of obtainable endoglin dissolution and the ratio of fms-like tyrosine kinase-1 (sFlt-1) to trophoblastic growth factor. Despite the fact that experimental groups received a same quantity of placental growth factor, this was the case (PlGF). sFlt-1 to PlGF ratio as well as the PE without accompanying FGR cohort were the two areas in which the most prominent outliers were discovered. Since preeclamptic persons have the greatest sFlt-1 levels, this factor may be responsible for the development of PE in the mother due to ischemic placental disease.

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The role of oligohydramnios and fetal growth restriction in adverse pregnancy outcomes in preeclamptic patients

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Ginekologia Polska" are listed in PubMed.

Cited by 7 publications

References 28 publications

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A Review of the Studies on Placental Mesenchymal Stem Cells and Their Exosomes Applied to Preeclampsia

Different clinical presentation of two pregnancy syndromes: Similar pro and antiangiogenic characteristics near delivery: Fetal growth preeclampsia

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