The role of octopamine in locusts and other arthropods

Verlinden, Heleen; Vleugels, Rut; Marchal, Elisabeth; Badisco, Liesbeth; Pflüger, Hans‐Joachim; Blenau, Wolfgang; Broeck, Jozef Vanden

doi:10.1016/j.jinsphys.2010.05.018

Cited by 143 publications

(135 citation statements)

References 162 publications

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“…The apparent dominance of OA vs. either DA or 5-HT for the behaviors we have studied here may be surprising, but is consistent with a range of other studies in invertebrates demonstrating the fundamental importance of OA in a variety of basic behaviors (Bicker 1999;Roeder 1999;Scheiner et al 2006;Chase and Koelle 2007;Verlinden et al 2010). It is conceivable that we failed to detect the importance of 5-HT in some cases because of the limited rescue of 5-HT levels using the relatively weak TrH-Gal4 driver.…”

Section: Discussionsupporting

confidence: 87%

“…The findings are consistent with previous studies demonstrating the widespread importance of OA in multiple aspects of invertebrate behavior (Bicker 1999;Roeder 1999;Scheiner et al 2006;Chase and Koelle 2007;Verlinden et al 2010). Both DA and OA can individually rescue male courtship and male fertility, suggesting potentially redundant roles for these systems in stimulating male sexual behavior.…”

supporting

confidence: 92%

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Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin inDrosophila melanogaster

Chen

Lebestky

et al. 2013

Genetics

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To investigate the regulation of Drosophila melanogaster behavior by biogenic amines, we have exploited the broad requirement of the vesicular monoamine transporter (VMAT) for the vesicular storage and exocytotic release of all monoamine neurotransmitters. We used the Drosophila VMAT (dVMAT) null mutant to globally ablate exocytotic amine release and then restored DVMAT activity in either individual or multiple aminergic systems, using transgenic rescue techniques. We find that larval survival, larval locomotion, and female fertility rely predominantly on octopaminergic circuits with little apparent input from the vesicular release of serotonin or dopamine. In contrast, male courtship and fertility can be rescued by expressing DVMAT in octopaminergic or dopaminergic neurons, suggesting potentially redundant circuits. Rescue of major aspects of adult locomotion and startle behavior required octopamine, but a complementary role was observed for serotonin. Interestingly, adult circadian behavior could not be rescued by expression of DVMAT in a single subtype of aminergic neurons, but required at least two systems, suggesting the possibility of unexpected cooperative interactions. Further experiments using this model will help determine how multiple aminergic systems may contribute to the regulation of other behaviors. Our data also highlight potential differences between behaviors regulated by standard exocytotic release and those regulated by other mechanisms. BOTH invertebrate and mammalian behaviors undergo extensive regulation by monoamine neurotransmitters (reviewed in Joshua et al.

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Section: Discussionsupporting

confidence: 87%

supporting

confidence: 92%

Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin inDrosophila melanogaster

Chen

Lebestky

et al. 2013

Genetics

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“…It has also been shown to increase in concentration in locusts in response to stress (Verlinden et al , 2010). The role of induced octopamine in response to feeding by R. padi in our study is unclear, but interestingly it has also been shown to accumulate during the interaction of tomato plants with the bacterial pathogen P. syringae pv.…”

Section: Discussionmentioning

confidence: 99%

Triticum monococcumlines with distinct metabolic phenotypes and phloem-based partial resistance to the bird cherry-oat aphidRhopalosiphum padi

et al. 2016

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Crop protection is an integral part of establishing food security, by protecting the yield potential of crops. Cereal aphids cause yield losses by direct damage and transmission of viruses. Some wild relatives of wheat show resistance to aphids but the mechanisms remain unresolved. In order to elucidate the location of the partial resistance to the bird cherry–oat aphid, Rhopalosiphum padi, in diploid wheat lines of Triticum monococcum, we conducted aphid performance studies using developmental bioassays and electrical penetration graphs, as well as metabolic profiling of partially resistant and susceptible lines. This demonstrated that the partial resistance is related to a delayed effect on the reproduction and development of R. padi. The observed partial resistance is phloem based and is shown by an increase in number of probes before the first phloem ingestion, a higher number and duration of salivation events without subsequent phloem feeding and a shorter time spent phloem feeding on plants with reduced susceptibility. Clear metabolic phenotypes separate partially resistant and susceptible lines, with the former having lower levels of the majority of primary metabolites, including total carbohydrates. A number of compounds were identified as being at different levels in the susceptible and partially resistant lines, with asparagine, octopamine and glycine betaine elevated in less susceptible lines without aphid infestation. In addition, two of those, asparagine and octopamine, as well as threonine, glutamine, succinate, trehalose, glycerol, guanosine and choline increased in response to infestation, accumulating in plant tissue localised close to aphid feeding after 24 h. There was no clear evidence of systemic plant response to aphid infestation.

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“…Octopamine and tyramine are characterized as neurotransmitters, neurohormones and neuromodulators (Roeder et al, 2003;Roeder, 2005;Farooqui, 2012;Ohta and Ozoe, 2014). While the diverse physiological functions of octopamine have been realized for some time, we are only starting to understand the physiological relevance of tyramine; this is because, until recently, tyramine was thought to only be a synthetic precursor to octopamine (Guerrero and Dowd, 2010;Roeder et al, 2003;Roeder, 2005;Verlinden et al, 2010;Farooqui, 2012). Octopamine receptors are believed to be the target of formamidine insecticides/acaricides, which include chlordimeform and amitraz (Blenau et al, 2012;Hashemzadeh et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

“…However, the functional identification of these receptors ligands has yet to be performed. In fact, it has been hypothesized, based on sequence similarity, that the originally identified receptor is a tyramine receptor, instead of an octopamine receptor (Verlinden et al, 2010;Farooqui, 2012). The objectives of this study were to (1) functionally characterize the putative tyramine receptor from the southern cattle tick, and (2) determine the receptor pharmacology using functional assays.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological characterization of a tyramine receptor from the southern cattle tick, Rhipicephalus (Boophilus) microplus

Gross

Temeyer

Day

et al. 2015

Insect Biochemistry and Molecular Biology

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The southern cattle tick (Rhipicephalus (Boophilus) microplus) is a hematophagous external parasite that vectors the causative agents of bovine babesiosis or cattle tick fever, Babesia bovis and B. bigemina, and anaplasmosis, Anaplasma marginale. The southern cattle tick is a threat to the livestock industry in many locations throughout the world. Control methods include the use of chemical acaricides including amitraz, a formamidine insecticide, which is proposed to activate octopamine receptors. Previous studies have identified a putative octopamine receptor from the southern cattle tick in Australia and the Americas. Furthermore, this putative octopamine receptor could play a role in acaricide resistance to amitraz. Recently, sequence data indicated that this putative octopamine receptor is probably a type-1 tyramine receptor (TAR1). In this study, the putative TAR1 was heterologously expressed in Chinese hamster ovary (CHO-K1) cells, and the expressed receptor resulted in a 39-fold higher potency for tyramine compared to octopamine. Furthermore, the expressed receptor was strongly antagonized by yohimbine and cyproheptadine, and mildly antagonized by mianserin and phentolamine. Tolazoline and naphazoline had agonistic or modulatory activity against the expressed receptor, as did the amitraz metabolite, BTS-27271; however, this was only observed in the presence of tyramine. The southern cattle tick's tyramine receptor may serve as a target for the development of anti-parasitic compounds, in addition to being a likely target of formamidine insecticides. RightsWorks produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted. a b s t r a c tThe southern cattle tick (Rhipicephalus (Boophilus) microplus) is a hematophagous external parasite that vectors the causative agents of bovine babesiosis or cattle tick fever, Babesia bovis and B. bigemina, and anaplasmosis, Anaplasma marginale. The southern cattle tick is a threat to the livestock industry in many locations throughout the world. Control methods include the use of chemical acaricides including amitraz, a formamidine insecticide, which is proposed to activate octopamine receptors. Previous studies have identified a putative octopamine receptor from the southern cattle tick in Australia and the Americas. Furthermore, this putative octopamine receptor could play a role in acaricide resistance to amitraz. Recently, sequence data indicated that this putative octopamine receptor is probably a type-1 tyramine receptor (TAR1). In this study, the putative TAR1 was heterologously expressed in Chinese hamster ovary (CHO-K1) cells, and the expressed receptor resulted in a 39-fold higher potency for tyramine compared to octopamine. Furthermore, the expressed receptor was strongly antagonized by yohimbine and cyproheptadine, and mildly antagonized by mianserin and phentolamine. Tolazoline and naphazoline had agonistic or modulatory activity against the expresse...

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The role of octopamine in locusts and other arthropods

Cited by 143 publications

References 162 publications

Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin inDrosophila melanogaster

Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin inDrosophila melanogaster

Triticum monococcumlines with distinct metabolic phenotypes and phloem-based partial resistance to the bird cherry-oat aphidRhopalosiphum padi

Pharmacological characterization of a tyramine receptor from the southern cattle tick, Rhipicephalus (Boophilus) microplus

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