The role of nutritional habits during gestation and child life in pediatric brain tumor etiology

Lubin, Flora; Farbstein, Hanan; Chetrit, Angela; Farbstein, Moti; Freedman, Laurence S.; Alfandary, Esther; Modan, Baruch

doi:10.1002/(sici)1097-0215(20000401)86:1<139::aid-ijc22>3.0.co;2-c

Cited by 41 publications

(40 citation statements)

References 15 publications

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“…There was little consistency in the relationship when individual cured meats were investigated. Lubin et al (2000) observed no association of mother's nitrate, nitrite, or vitamin C intake during gestation and risk for a brain tumor in the child. However, children with brain tumors had higher consumption of vegetable fat than did controls (OR = 1.4; 95% CI 1.1-1.7), and their mothers had consumed more potassium during gestation than had control mothers (OR = 1.4; 95% CI 1.0-2.0).…”

Section: Diet and Vitaminsmentioning

confidence: 99%

“…Epidemiologic studies of diet and vitamin supplementation have provided mixed support for the hypothesis that dietary N-nitroso compounds, antioxidants, or speci c nutrients might in uence the risk of either childhood or adult brain tumors, as reviewed in a number of reports (Berleur and Cordier, 1995;PrestonMartin and Mack, 1996;Wrensch et al, 1993), including some published more recently Hu et al, 1999;Kaplan et al, 1997;Lee et al, 1997;Lubin et al, 2000;Tedeschi-Blok et al, 2001). In a review of the relationship between childhood cancer and cured meat in the diet, Blot et al (1999) observed that most studies found no statistically significant association between the mother's total consumption of cured meat during the index pregnancy and the risk for developing a brain tumor in the child, but more studies found positive rather than negative relationships.…”

Section: Diet and Vitaminsmentioning

confidence: 99%

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Epidemiology of primary brain tumors: Current concepts and review of the literature

Wrensch¹,

Minn²,

Chew³

et al. 2002

Neuro-Oncol

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Neuro-OncologyThe purpose of this review is to provide a suf ciently detailed perspective on epidemiologic studies of primary brain tumors to encourage multidisciplinary etiologic and prognostic studies among surgeons, neuro-oncologists, epidemiologists, and molecular scientists. Molecular tumor markers that predict survival and treatment response are being identi ed with hope of even greater gains in this area from emerging array technologies. Regarding risk factors, studies of inherited susceptibility and constitutive polymorphisms in genes pertinent to carcinogenesis (for example, DNA repair and detoxi cation genes and mutagen sensitivity) have revealed provocative ndings. Inverse associations of the history of allergies with glioma risk observed in 3 large studies and reports of inverse associations of glioma with common infections suggest a possible role of immune factors in glioma genesis or progression. Studies continue to suggest that brain tumors might result from workplace, dietary, and other personal and residential exposures, but studies of cell phone use and power frequency electromagnetic elds have found little to support a causal connection with brain tumors; caveats remain. The only proven causes of brain tumors (that is, rare hereditary syndromes, therapeutic radiation, and immune suppression giving rise to brain lymphomas) account for a small proportion of cases. Progress in understanding primary brain tumors might result from studies of well-de ned histologic and molecular tumor types incorporating assessment of potentially relevant information on subject susceptibility and environmental and noninherited endogenous factors (viruses, radiation, and carcinogenic or protective chemical exposures through diet, workplace, oxidative metabolism, or other sources). Such studies will require the cooperation of researchers from many disciplines. Neuro-Oncology 4, 278-299, 2002 (Posted to Neuro-Oncology [serial online], Doc. 02-011, August 27, 2002 P rimary malignant or benign brain tumors were estimated to be newly diagnosed in about 35,519 Americans in 2001 (CBTRUS, 2000. Epidemiologic studies enhance our understanding of this heterogeneous group of diseases in 2 ways. Descriptive studies characterize the incidence of brain tumors and the mortality and survival rates associated with them with respect to histologic tumor type and demographic characteristics of patients affected, such as their age, sex, and geographic region. Analytic epidemiologic studies either compare the risk of brain tumors in people with and without certain characteristics (cohort studies) or compare the histories of people with and without brain tumors (case-control studies) to provide information on a wide range of possible risk factors, including diet, smoking, alcohol, occupation and industry, exposure to ionizing or nonionizing radiation, infections, allergies, head trauma, family history, and inherited polymorphisms in genes related to carcinogen metabolism, oxidative metabolism, and DNA repair. Because of the relative ra...

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Section: Diet and Vitaminsmentioning

confidence: 99%

Section: Diet and Vitaminsmentioning

confidence: 99%

Epidemiology of primary brain tumors: Current concepts and review of the literature

Wrensch¹,

Minn²,

Chew³

et al. 2002

Neuro-Oncol

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“…However, the effects of periconceptional folate intake or folic acid supplementation on other cancers have been examined in epidemiologic studies with inconsistent results [129]. While a protective effect of periconceptional maternal folic acid supplementation on several pediatric cancers has been shown in some studies [130][131][132][133][134], other studies have not confirmed this protective effect [135][136][137] and some have even shown an increased risk [132]. A meta-analysis of seven of these studies reported a protective effect of folic acidcontaining multivitamin supplements on childhood leukemia including acute lymphocytic leukemia and on pediatric brain tumors, especially neuroblastoma [138].…”

Section: Maternal and Early Life Folate Nutrition And Colorectal Cancmentioning

confidence: 99%

Current Status of Folic Acid Supplementation on Colorectal Cancer Prevention

Kim

2016

Curr Pharmacol Rep

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Folate and its synthetic form, folic acid, play an important role in one-carbon transfer reactions involved in DNA synthesis and methylation, aberrations of which contribute to the development of colorectal cancer. Indeed, a portfolio of epidemiologic evidence suggests an inverse association between folate status and colorectal cancer risk. However, animal studies and clinical trials collectively suggest a dual modulatory effect of folic acid supplementation on colorectal cancer risk depending on the stage of cell transformation at the time of intervention. Folic acid supplementation may prevent neoplastic initiation in the colorectum but it may promote the progression of established precancerous lesions. Concerns have been raised over whether or not the significantly increased intake and blood levels of folate resulting from folic acid fortification and prevalent supplemental folic acid use would increase the incidence and mortality of cancer in North America. Recent epidemiologic studies, however, have reported a decreasing trend of colorectal cancer incidence postfortification in the USA and have not demonstrated a colorectal cancer-promoting effect of folic acid supplementation.Nevertheless, the effect of the dramatically increased folate status in North America on cancer incidence and mortality requires continued careful monitoring, given serious pubic health ramifications. At present, based on the lack of compelling supportive evidence and on the potential tumorpromoting effect, folic acid supplementation should not be recommended as a chemopreventive measure against colorectal cancer or any other cancers. Whether or not folic acid supplementation can prevent the development of colorectal cancer remains a highly controversial and complex topic at present.

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“…We have previously investigated vitamin supplementation and dietary folate intake in infants and children under 3 years of age, but no associations were seen [5]. Two other studies investigated childhood dietary folate intake and reported no associations [6,7]. Studies examining childhood fruit/vegetable and supplement intake were reviewed in 2005 [8]; two out of three studies of multivitamins reported ORs below the null (one reported no association), while out of five studies of fruit and vegetables, one reported nonsignificant ORs above the null, one reported no association, two reported nonsignificant ORs below the null, and one reported a significant inverse association.…”

Section: Introductionmentioning

confidence: 99%

Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case–control study

Greenop

Miller

Bailey

et al. 2015

Cancer Causes Control

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The role of nutritional habits during gestation and child life in pediatric brain tumor etiology

Cited by 41 publications

References 15 publications

Epidemiology of primary brain tumors: Current concepts and review of the literature

Epidemiology of primary brain tumors: Current concepts and review of the literature

Current Status of Folic Acid Supplementation on Colorectal Cancer Prevention

Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case–control study

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