The Role of Nutrition in Cognitive Function and Brain Ageing in the Elderly

Gardener, Samantha L.; Rainey-Smith, Stephanie R.

doi:10.1007/s13668-018-0229-y

Cited by 54 publications

(34 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results are in line with population-based studies, which observed a positive association between adherence to the Mediterranean diet [43][44][45][46], or MIND diet and cognitive decline or dementia [15,16,18,20]. While not all cross-sectional [21,22] and longitudinal [47][48][49] studies did replicate these findings, a meta-analysis on the Mediterranean diet and a systematic review of the MIND diet 50,51]. Extending the evidence from these population-based studies, we here show that higher adherence to the Mediterranean diet and MIND diet are also associated with cognitive outcomes in a sample enriched with subjects who are either clinically or genetically at increased risk for AD.…”

Section: Discussionsupporting

confidence: 87%

Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer’s disease

et al. 2020

View full text Add to dashboard Cite

Purpose To investigate cross-sectional associations between dietary patterns and cognitive functioning in elderly free of dementia. Methods Data of 389 participants from the German DELCODE study (52% female, 69 ± 6 years, mean Mini Mental State Score 29 ± 1) were included. The sample was enriched with elderly at increased risk for Alzheimer's disease (AD) by including participants with subjective cognitive decline, mild cognitive impairment (MCI) and siblings of AD patients. Mediterranean and MIND diets were derived from 148 Food Frequency Questionnaire items, and data-driven patterns by principal component analysis (PCA) of 39 food groups. Associations between dietary patterns and five cognitive domain scores were analyzed with linear regression analyses adjusted for demographics (model 1), and additionally for energy intake, BMI, other lifestyle variables and APOe4-status (model 2). For PCA-derived dietary components, final model 3 included all other dietary components. Results In fully adjusted models, adherence to Mediterranean and MIND diet was associated with better memory. The 'alcoholic beverages' PCA component was positively associated with most cognitive domains. Exclusion of MCI subjects (n = 60) revealed that Mediterranean and MIND diet were also related to language functions; associations with the alcoholic beverages component were attenuated, but most remained significant. Conclusion In line with data from elderly population samples, Mediterranean and MIND diet and some data-derived dietary patterns were related to memory and language function. Longitudinal data are needed to draw conclusions on the putative effect of nutrition on the rate of cognitive decline, and on the potential of dietary interventions in groups at increased risk for AD.

show abstract

Section: Discussionsupporting

confidence: 87%

Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer’s disease

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Diet is now being investigated beyond its benefits for physical health, and is increasingly recognized as a promising modifiable risk factor to protect against mood disturbances and age-associated cognitive decline [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Inter-individual differences in age-associated brain dysfunction provide opportunity to characterize the relationship between diet quality and psychological outcomes in middle age, prior to the presence of significant brain pathology.…”

Section: Introductionmentioning

confidence: 99%

Self-Reported Diet Quality Differentiates Nutrient Intake, Blood Nutrient Status, Mood, and Cognition: Implications for Identifying Nutritional Neurocognitive Risk Factors in Middle Age

et al. 2020

View full text Add to dashboard Cite

Evidence for diet quality representing a modifiable risk factor for age-related cognitive decline and mood disturbances has typically come from retrospective, cross-sectional analyses. Here a diet screening tool (DST) was used to categorize healthy middle-aged volunteers (n = 141, 40–65 years) into “optimal” or “sub-optimal” diet groups to investigate cross-sectional associations between diet quality, cognitive function, and mood. The DST distinguished levels of nutrient intake as assessed by Automated Self-Administered 24-h dietary recall and nutrient status, as assessed by blood biomarker measures. Compared with the “sub-optimal” group, the “optimal” diet group showed significantly higher intake of vitamin E (p = 0.007), magnesium (p = 0.001), zinc (p = 0.043) and fiber (p = 0.015), higher circulating levels of vitamin B6 (p = 0.030) and red blood cell folate (p = 0.026) and lower saturated fatty acids (p = 0.012). Regarding psychological outcomes, the “optimal” diet group had significantly better Stroop processing than those with a “sub-optimal” diet (p = 0.013). Regression analysis revealed that higher DST scores were associated with fewer mood disturbances (p = 0.002) and lower perceived stress (p = 0.031), although these differences were not significant when comparing “optimal” versus “sub-optimal” as discrete groups. This study demonstrates the potential of a 20-item diet screen to identify both nutritional and psychological status in an Australian setting.

show abstract

“…To our knowledge, this is the first study to evaluate the association between adherence to the MIND diet and mortality. Conformity to the MIND diet has been demonstrated to be more effective in slowing cognitive decline and reducing incidence of Alzheimer's disease than either the DASH or Mediterranean diets (14,29,30) . Our findings indicate an overall impact on health, of the MIND diet, which may extend beyond neuroprotection.…”

Section: Discussionmentioning

confidence: 99%

Adherence to the MIND diet is associated with 12-year all-cause mortality in older adults

Corley

2020

Public Health Nutr.

View full text Add to dashboard Cite

Objective: To prospectively evaluate the association of three dietary patterns: the MIND (Mediterranean-DASH diet intervention for Neurodegenerative Delay) diet; a Mediterranean-type diet and a traditional diet, with all-cause mortality over a 12-year period in an older sample. Design: A longitudinal birth cohort study. We ascertained dietary patterns using FFQ data at baseline (2004–2007) and mortality using linkage data. Cox regression was used to estimate mortality hazard ratios (HR) with adjustment for confounders. Setting: The Lothian Birth Cohort 1936 (LBC1936) study in Edinburgh, Scotland. Participants: Dietary patterns were ascertained in 882 participants, mean age 69·5 (±0·8) years, at baseline. During the 12-year follow-up (to October 2019), 206 deaths occurred. Results: In the basic-adjusted model, all three dietary patterns were significantly associated with mortality, the MIND diet and Mediterranean-type diet with a lower risk and the traditional diet with a higher risk. In fully adjusted models, MIND diet score was inversely related to all-cause mortality (HR 0·88; 95 % CI 0·79, 0·97) such that the risk of death was reduced by 12 % per unit increase in MIND diet score. Participants in the top compared with the bottom third of MIND diet score had a 37 % lower risk of death (HR 0·63; 95 % CI 0·41, 0·96). No significant associations with the Mediterranean-type or traditional dietary patterns were observed in the final multivariate model. Conclusions: Our findings suggest that closer adherence to the MIND diet is associated with a significantly lower risk of all-cause mortality, over 12 years of follow-up, and may constitute a valid public health recommendation for prolonged survival.

show abstract

The Role of Nutrition in Cognitive Function and Brain Ageing in the Elderly

Cited by 54 publications

References 65 publications

Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer’s disease

Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer’s disease

Self-Reported Diet Quality Differentiates Nutrient Intake, Blood Nutrient Status, Mood, and Cognition: Implications for Identifying Nutritional Neurocognitive Risk Factors in Middle Age

Adherence to the MIND diet is associated with 12-year all-cause mortality in older adults

Contact Info

Product

Resources

About