The Role of Nutrient-Based Epigenetic Changes in Buffering Against Stress, Aging, and Alzheimer’s Disease

Chiu, Simon; Woodbury-Fariña, Michel A.; Shad, Mujeeb U.; Husni, Mariwan; Copen, John; Bureau, Y; Cernovsky, Zack Z.; Hou, Jirui; Raheb, Hana; Terpstra, Kristen; Sánchez, Verónica; Hategan, Ana; Kaushal, Mike; Campbell, Robbie

doi:10.1016/j.psc.2014.09.001

Cited by 20 publications

(16 citation statements)

References 163 publications

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“…Human longitudinal studies based on direct or indirect indices of n-3 PUFA consumption correlate with better cognitive functioning and reduced risk of dementia, higher total brain and regional gray matter volumes [44][45][46][47][48][49] and reduced white matter hyperintensity [50,51]. Some interventional studies reported that n-3 PUFA supplementation improves cognition in healthy elderly subjects [52][53][54] and in subjects with MCI [55][56][57][58]. Many reports have also demonstrated the benefits of a diet rich in n-3 PUFA, as the Mediterranean diet, against age-related cognitive decline in MCI subjects and AD patients [59][60][61][62][63][64][65].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Role of Dietary Supplementation with Omega-3 Fatty Acids in the Presence of Basal Forebrain Cholinergic Neurons Degeneration in Aged Mice

Cutuli

Landolfo

Decandia

et al. 2020

IJMS

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As major components of neuronal membranes, omega-3 polyunsaturated fatty acids (n-3 PUFA) exhibit a wide range of regulatory functions. Recent human and animal studies indicate that n-3 PUFA may exert beneficial effects on aging processes. Here we analyzed the neuroprotective influence of n-3 PUFA supplementation on behavioral deficits, hippocampal neurogenesis, volume loss, and astrogliosis in aged mice that underwent a selective depletion of basal forebrain cholinergic neurons. Such a lesion represents a valid model to mimic a key component of the cognitive deficits associated with dementia. Aged mice were supplemented with n-3 PUFA or olive oil (as isocaloric control) for 8 weeks and then cholinergically depleted with mu-p75-saporin immunotoxin. Two weeks after lesioning, mice were behaviorally tested to assess anxious, motivational, social, mnesic, and depressive-like behaviors. Subsequently, morphological and biochemical analyses were performed. In lesioned aged mice the n-3 PUFA pre-treatment preserved explorative skills and associative retention memory, enhanced neurogenesis in the dentate gyrus, and reduced volume and VAChT levels loss as well as astrogliosis in hippocampus. The present findings demonstrating that n-3 PUFA supplementation before cholinergic depletion can counteract behavioral deficits and hippocampal neurodegeneration in aged mice advance a low-cost, non-invasive preventive tool to enhance life quality during aging.

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Section: Introductionmentioning

confidence: 99%

Neuroprotective Role of Dietary Supplementation with Omega-3 Fatty Acids in the Presence of Basal Forebrain Cholinergic Neurons Degeneration in Aged Mice

Cutuli

Landolfo

Decandia

et al. 2020

IJMS

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“…There are far deeper and longer-lasting effects of Pb exposure. Multiple latent sequelae exist of Pb exposure to sub-toxic levels (Bakulski, 2013;Basha et al, 2005a;Basha et al, 2005b;Bihaqi et al, 2014;Bolin et al, 2006;Chiu et al, 2014;Eid et al, 2016;Masoud et al, 2016;Sen et al, 2015a;Sen et al, 2015b;Wu et al, 2008). Pb exposure can instill latent epigenetic modifications (Zawia et al, 2009) that occur in the absence of toxicity symptoms.…”

Section: Consequences Of Environmental Catastrophes Have Complex Healmentioning

confidence: 99%

Latent consequences of early-life lead (Pb) exposure and the future: Addressing the Pb crisis

et al. 2018

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“…As mentioned widely in scientific literature, the interaction between diet and epigenetics is the best documented in cancer pathology (Ho et al, 2009 ; Shu et al, 2010 ). Furthermore, based on evidence in support of epigenomics in regulating gene expression in stress-mediated AD risk factors, and the pathophysiology of AD, there has been growing interest in examining whether diet and nutraceuticals targeting epigenomics may prevent, delay, or reverse the course of AD (Chiu et al, 2014 ). In this regard, the Mediterranean diet rich in vegetables, fruits and nuts, legumes, olive oil and fish with relative low intakes of red meat has been suggested to reduce the risk for AD onset (Scarmeas et al, 2009 ; Frisardi et al, 2010 ).…”

Section: Alzheimer’s Disease and Epigeneticsmentioning

confidence: 99%

Epigenetic mechanisms in neurological and neurodegenerative diseases

Landgrave-Gómez

Mercado-Gómez

Guevara‐Guzmán

2015

Front. Cell. Neurosci.

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The role of epigenetic mechanisms in the function and homeostasis of the central nervous system (CNS) and its regulation in diseases is one of the most interesting processes of contemporary neuroscience. In the last decade, a growing body of literature suggests that long-term changes in gene transcription associated with CNS’s regulation and neurological disorders are mediated via modulation of chromatin structure. “Epigenetics”, introduced for the first time by Waddington in the early 1940s, has been traditionally referred to a variety of mechanisms that allow heritable changes in gene expression even in the absence of DNA mutation. However, new definitions acknowledge that many of these mechanisms used to perpetuate epigenetic traits in dividing cells are used by neurons to control a variety of functions dependent on gene expression. Indeed, in the recent years these mechanisms have shown their importance in the maintenance of a healthy CNS. Moreover, environmental inputs that have shown effects in CNS diseases, such as nutrition, that can modulate the concentration of a variety of metabolites such as acetyl-coenzyme A (acetyl-coA), nicotinamide adenine dinucleotide (NAD + ) and beta hydroxybutyrate (β-HB), regulates some of these epigenetic modifications, linking in a precise way environment with gene expression. This manuscript will portray what is currently understood about the role of epigenetic mechanisms in the function and homeostasis of the CNS and their participation in a variety of neurological disorders. We will discuss how the machinery that controls these modifications plays an important role in processes involved in neurological disorders such as neurogenesis and cell growth. Moreover, we will discuss how environmental inputs modulate these modifications producing metabolic and physiological alterations that could exert beneficial effects on neurological diseases. Finally, we will highlight possible future directions in the field of epigenetics and neurological disorders.

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The Role of Nutrient-Based Epigenetic Changes in Buffering Against Stress, Aging, and Alzheimer’s Disease

Cited by 20 publications

References 163 publications

Neuroprotective Role of Dietary Supplementation with Omega-3 Fatty Acids in the Presence of Basal Forebrain Cholinergic Neurons Degeneration in Aged Mice

Neuroprotective Role of Dietary Supplementation with Omega-3 Fatty Acids in the Presence of Basal Forebrain Cholinergic Neurons Degeneration in Aged Mice

Latent consequences of early-life lead (Pb) exposure and the future: Addressing the Pb crisis

Epigenetic mechanisms in neurological and neurodegenerative diseases

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