The role of nutraceuticals in heart failure muscle wasting as a result of inflammatory activity. The International Lipid Expert Panel (ILEP) Position Paper.

Abstract

Muscle wasting is one of the main causes for exercise intolerance and ventilatory inefficiency in patients with heart failure and a strong predictor of frailty and reduced survival. The prevalence of sarcopenia is at least 20% in patients with heart failure. Patients with heart failure often have subclinical systemic inflammation, which may exert sustained effects on skeletal muscle. Besides exercise, nutrition should also be carefully evaluated, as an appropriate diet with selected nutraceuticals may be able to stimulate muscle anabolism and inhibit muscle catabolism. This review summarizes the epidemiological and clinical trial evidence supporting the recommendations for the use of nutraceuticals with anti-inflammatory properties in heart failure and provides an overview of the state of the evidence for nutraceutical supplementation to prevent and/or mitigate heart failure muscle wasting.

Timing of decongestion and its impact on acute heart failure prognosis

“…The analyses are derived from the pre-existing data; thus, some important parameters, e.g. uric acid [ 18 ] or sarcopenia status [ 19 ], were not assessed and their impact was not evaluated. Importantly, the haemoconcentration would reflect the changes in the intravascular volume, being a rather poor indicator of the tissue volume overload fluctuations.…”

The year in nutrition medicine 2023

“…Well-selected and adequately dosed nutraceuticals could exert a positive impact on largely prevalent diseases like non-alcoholic fatty liver disease [ 16 ] and in severe pathological conditions, including the skeletal muscle wasting in patients with heart failure [ 17 ].…”