The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking

Ikemoto, Satoshi; Panksepp, Jaak

doi:10.1016/s0165-0173(99)00023-5

Cited by 1,305 publications

(988 citation statements)

References 286 publications

Supporting

Mentioning

914

Contrasting

Unclassified

Order By: Relevance

“…The postpartum female is uniquely and highly responsive to pups: she vigorously performs maternal caregiving behaviors toward her pups across the postpartum period and attributes considerable incentive salience to pups during early postpartum (Wilsoncroft 1969;Lee et al 2000;Mattson et al 2001). Pup-directed maternal behaviors substantially increase dopaminergic activity in the nucleus accumbens (Hansen et al 1993;Champagne et al 2004), a mesolimbic region closely tied to motivational processing, goal-directed behaviors (Berridge and Robinson 1998;Ikemoto and Panksepp 1999;Salamone and Correa 2002), and, recently, cocaine-associated chamber preference (Mattson and Morrell 2005). As dynamic endogenous changes in the female's endocrine state also modulate mesolimbic responsivity (Bazzett and Becker 1994;Bakowska and Morrell 1995), both pup-induced and endocrineassociated changes in dopaminergic tone across postpartum may contribute to cocaine's unique incentive salience in the postpartum female rat.…”

Section: Discussionmentioning

confidence: 99%

Incentive salience of cocaine across the postpartum period of the female rat

et al. 2008

View full text Add to dashboard Cite

Rationale-Objectives-Our prior conditioned place preference (CPP) work demonstrates that late (day16) postpartum female rats consistently prefer cocaine-over pup-associated chambers, whereas far fewer early postpartum (day8) females prefer the cocaine-associated chamber. The present study examines early and late postpartum females' preference for a cocaine-associated chamber when contrasted with a chamber associated with saline (rather than pups).Materials and methods-Postpartum females were tested for conditioned preference for chambers associated with cocaine (10 mg/kg subcutaneous (SC) or 0.5, 5, 10, or 20 mg/kg intraperitoneal (IP) injections) versus saline; preferences of virgin female and male rats for select cocaine stimuli (10mg/kg SC or IP) were also tested. Locomotion was recorded during CPP conditioning and testing.Results-Early and late postpartum females expressed strikingly similar preference for the cocaineassociated chamber across all administration routes and doses. IP cocaine produced an orderly, inverted U-shaped dose-preference curve, with preference peaking at the 5 mg/kg dose (83% of females). While many postpartum females preferred 10mg/kg cocaine administered either SC or IP, both virgin females and males expressed strong aversion to SC cocaine and, while virgin females strongly preferred IP cocaine, males remained relatively indifferent. Across 10mg/kg IP cocaineconditioning sessions, locomotor sensitization occurred exclusively in cocaine-but not salinepreferring postpartum females. Locomotor rate was lower in preferred versus nonpreferred chambers at CPP test.Conclusions-Early and late postpartum females may be equally and uniquely susceptible to sampling and/or abuse of modestly salient doses of cocaine (10mg/kg SC; 5mg/kg IP) compared to virgin females and/or males.

show abstract

Section: Discussionmentioning

confidence: 99%

Incentive salience of cocaine across the postpartum period of the female rat

et al. 2008

View full text Add to dashboard Cite

show abstract

“…A possible explanation may be found in the interpretation of dopamine's role in motivation by Ikemoto and Panksepp (1999). These authors propose that nucleus accumbens dopamine may modulate a flexible response system (a system that operates when animals are learning about incentive contingencies in their environment) (Ikemoto and Panksepp, 1999, p. 16) in the presence of salient stimuli.…”

Section: Discussionmentioning

confidence: 99%

“…It has been proposed to mediate the sensory pleasure of reward (Wise, 1982) and incentive learning (Beninger, 1983;Di Chiara, 1998, 1999, 2002. Other authors have suggested a role in the attribution of incentive salience to different stimuli (Berridge and Robinson, 1998;Robinson and Berridge, 1993) or in the invigoration of behaviors (Ikemoto and Panksepp, 1999;Salamone and Correa, 2002). Dopamine may also play a role in the prediction or anticipation of rewarded events (Blackburn et al, 1987(Blackburn et al, , 1989Schultz, 2002;Schultz et al, 1997;Weingarten and Martin, 1989), conditioned locomotion (Jones and Robbins, 1992), as well as response selection taking into account costs and benefits Salamone and Correa, 2002).…”

Section: Introductionmentioning

confidence: 99%

Differential Regulation of the Consummatory, Motivational and Anticipatory Aspects of Feeding Behavior by Dopaminergic and Opioidergic Drugs

Barbano

Cador

2005

Neuropsychopharmacol

114

View full text Add to dashboard Cite

Various aspects of feeding behavior (eg consumption, motivation and anticipation) are regulated by homeostatic and hedonic systems, and are modulated by dopaminergic and opioid brain systems. Here, we have studied the modulation of these aspects of feeding behavior by opioid and dopaminergic neurotransmission while taking into account food palatability and homeostatic state. Foods that varied in palatability were presented to either food sated or food restricted rats following injections of different doses of naloxone, an opioid receptor antagonist, or flupenthixol, a dopaminergic receptor antagonist, in behavioral paradigms that measured different aspects of feeding. Naloxone decreased food intake in a dose-dependent manner in sated rats given access to palatable food, without modifying food intake in food restricted rats. Flupenthixol did not have any effect on food intake. With regard to motivation, which was tested in a straight alley, naloxone increased the latency to reach the food only in sated rats presented with palatable food. Flupenthixol did not modify the latency of any group. Conditioned locomotor activity to repeated food presentation, a measure of anticipation, is expressed only in food restricted rats. Naloxone did not modify anticipatory activity, whereas flupenthixol decreased it only in food restricted rats presented with palatable food. These results reinforce the idea that the opioid system regulates feeding through the modulation of the perceived palatability of food. The dopaminergic system seems to be more important for the regulation of anticipatory activity related to motivationally relevant stimuli.

show abstract

“…Research on the role of dopamine in motivation focused mainly on appetitive motivation; however, dopamine appeared to be not only involved in processes of appetitive conditions but also in aversive conditions (Ikemoto and Panksepp, 1999;Salamone and Correa, 2002). Several studies in rats showed effects of nucleus accumbens dopamine levels on avoidance responses, indicating that nucleus accumbens dopamine is not only involved in approach responses to rewards but also in avoidance responses elicited by aversive stimuli (Ikemoto and Panksepp, 1999). In the present study, we focused on sexual incentive conditions; however, future studies may include various rewarding as well as aversive stimuli to investigate dopaminergic influences on appetitive and aversive motivation in humans.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Single Dose of Levodopa on Sexual Response in Men and Women

Both

Everaerd

Laan

et al. 2004

Neuropsychopharmacol

View full text Add to dashboard Cite

From animal research, there is ample evidence for a facilitating effect of dopamine on sexual behavior. In humans, little experimental research has been conducted on the inter-relation between dopamine and sexual response, even less so in women than in men. We investigated the effect of levodopa (100 mg) on sexual response in men and women following a double-blind, placebo-controlled crossover design. Genital and subjective sexual responses were measured as well as somatic motor system activity by means of Achilles tendon (T) reflex modulation. Genital and subjective sexual arousal were not affected by levodopa. However, the drug increased T reflex magnitude in response to sexual stimulation in men, but not in women. These results support the view that dopamine is involved in the energetic aspects of appetitive sexual behavior in men. The observed gender difference in the effect of levodopa is discussed in the perspective of possible dopamine-steroid interaction.

show abstract

The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking

Cited by 1,305 publications

References 286 publications

Incentive salience of cocaine across the postpartum period of the female rat

Incentive salience of cocaine across the postpartum period of the female rat

Differential Regulation of the Consummatory, Motivational and Anticipatory Aspects of Feeding Behavior by Dopaminergic and Opioidergic Drugs

Effect of a Single Dose of Levodopa on Sexual Response in Men and Women

Contact Info

Product

Resources

About