The role of Nrf2 in neural stem/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative disease

Kahroba, Houman; Ramezani, Bahman; Maadi, Hamid; Sadeghi, Mohammad Reza; Jaberie, Hajar; Ramezani, Fatemeh

doi:10.1016/j.arr.2020.101211

Cited by 78 publications

(71 citation statements)

References 169 publications

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“…Increasing evidence has shown that targeting ROS/NADPH oxidase, NLRP3 inflammasome, MAPK/NF-κB signaling, Nrf2 signaling, autophagy, and mitochondrial bioenergetics provides potential therapeutic strategies for the prevention and treatment of various inflammatory diseases [ 15 , 137 , 138 , 139 , 140 , 141 , 142 ]. However, given the multifactorial etiology of inflammatory diseases and the limited success of antioxidant therapies achieved to date, therapeutic targets at single risk factor interventions are not enough to block the progression of inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases

Chang

2021

IJMS

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Oxidative stress is a major contributor to the pathogenesis of various inflammatory diseases. Accumulating evidence has shown that oxidative stress is characterized by the overproduction of reactive oxygen species (ROS). Previous reviews have highlighted inflammatory signaling pathways, biomarkers, molecular targets, and pathogenetic functions mediated by oxidative stress in various diseases. The inflammatory signaling cascades are initiated through the recognition of host cell-derived damage associated molecular patterns (DAMPs) and microorganism-derived pathogen associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs). In this review, the effects of PRRs from the Toll-like (TLRs), the retinoic acid-induced gene I (RIG-I)-like receptors (RLRs) and the NOD-like (NLRs) families, and the activation of these signaling pathways in regulating the production of ROS and/or oxidative stress are summarized. Furthermore, important directions for future studies, especially for pathogen-induced signaling pathways through oxidative stress are also reviewed. The present review will highlight potential therapeutic strategies relevant to inflammatory diseases based on the correlations between ROS regulation and PRRs-mediated signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases

Chang

2021

IJMS

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“…Oxaliplatin resistance is a common phenomenon in the failure of treatment following the surgery 2 . Nuclear factor− erythroid 2−related factor 2 (Nrf2) plays a key role in the protection of cells against oxidative stress and inflammation in numerous tissues 3 and its role has been investigated in cancer stem cells 4,5 .…”

Section: Introductionmentioning

confidence: 99%

The Impact of Nrf2 Silencing on Nrf2-PD-L1 Axis to Overcome Oxaliplatin Resistance and Migration in Colon Cancer Cells

Payandeh¹,

Tazehkand²,

Mansoori³

et al. 2021

AJMB

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Background: Nuclear factor-erythroid 2-related factor 2 (Nrf2) plays a key role in promoting chemoresistance in various cancers. PD-L1 is one of the downstream targets of the Nrf2 signaling pathway. This molecule has some beneficial impacts on tumors growth by inhibition of the immune system. This study aimed to investigate the potential role of the Nrf2-PD-L1 axis in the promotion of oxaliplatin resistance in colon cancer cells. Methods: We examined Nrf2, PD- L1, and CD80 expression in the tumor and margin tissue samples from CRC patients. After that role of the Nrf2-PD-L1 axis in promotion of Oxaliplatin resistance was investigated. Results: Our data revealed that Nrf2 and PD-L1 mRNA expressions were markedly higher in tumor tissues compared to margin tissues. The PD-L1 mRNA expression level was also increased in the resistant cells. However, Nrf2 expression was decreased in SW480/Res cells and increased in LS174T/Res cells. The inhibition of Nrf2 through siRNA treatment in SW480/Res and LS174T/Res cells has decreased the IC50 values of oxaliplatin. Inhibition of the Nrf2 has significantly increased the oxaliplatin-induced apoptosis, and reduced the migration in SW480/Res cells. Conclusion: It is suggested that effective inhibition of Nrf2-PD-L1 signaling pathways can be considered as a novel approach to improve oxaliplatin efficacy in colon cancer patients.

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“…Treadmill exercise can reverse the related neuronal loss by preventing oxidative damage of DNA [ 115 ]. In healthy cells, many important antioxidant-related factors and enzymes, such as nuclear factor erythroid 2-related factor 2 (Nrf2) and superoxide dismutase 2 (SOD2), are present and involved in defending against oxidative damage [ 116 , 117 ]. In neurodegeneration, the decreased expression and function of such molecules is usually mediated by DNAm [ 118 , 119 ].…”

Section: Dnam For Neuroplasticity Neuronal Loss and Neurogenesis Under Exercisementioning

confidence: 99%

Roles of physical exercise in neurodegeneration: reversal of epigenetic clock

Zhu

Liu

et al. 2021

Transl Neurodegener

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The epigenetic clock is defined by the DNA methylation (DNAm) level and has been extensively applied to distinguish biological age from chronological age. Aging-related neurodegeneration is associated with epigenetic alteration, which determines the status of diseases. In recent years, extensive research has shown that physical exercise (PE) can affect the DNAm level, implying a reversal of the epigenetic clock in neurodegeneration. PE also regulates brain plasticity, neuroinflammation, and molecular signaling cascades associated with epigenetics. This review summarizes the effects of PE on neurodegenerative diseases via both general and disease-specific DNAm mechanisms, and discusses epigenetic modifications that alleviate the pathological symptoms of these diseases. This may lead to probing of the underpinnings of neurodegenerative disorders and provide valuable therapeutic references for cognitive and motor dysfunction.

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The role of Nrf2 in neural stem/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative disease

Cited by 78 publications

References 169 publications

Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases

Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases

The Impact of Nrf2 Silencing on Nrf2-PD-L1 Axis to Overcome Oxaliplatin Resistance and Migration in Colon Cancer Cells

Roles of physical exercise in neurodegeneration: reversal of epigenetic clock

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