The Role of Nrf2 in the Antioxidant Cellular Response to Medical Ozone Exposure

Galiè, Mirco; Covi, Viviana; Tabaracci, Gabriele; Malatesta, Manuela

doi:10.3390/ijms20164009

Cited by 97 publications

(99 citation statements)

References 155 publications

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“…Experimental results demonstrated that ozone ex vivo or in vivo can activate Nrf2 [7,37]. This mechanism can explain the genomic target of ozone, which induces the proteomic response (protein synthesis, as antioxidant enzymes: e.g., HO-1, SOD, CAT), providing far better protection against the total body damaging effects from free radicals.…”

Section: Modulation Of Oxidative Stress By Ozone Therapymentioning

confidence: 89%

“…As described in these works, rectal O 3 /O 2 insufflation at appropriated concentrations enhances the antioxidant mechanisms in renal tissue, which can explain its effect to prevent o diminish cisplatin-induced renal damage. Further support was provided years later, when it was described that appropriated O 3 /O 2 concentration (this is, a moderate ROS stimulus) induces Nrf2 as the mechanism for increasing HO-1 [27] and antioxidant mechanisms leading to decrease in oxidative stress and pro-inflammatory cytokines [7,37,38,51].…”

Section: Ozone and Cisplatin-induced Toxicitymentioning

confidence: 99%

“…It is becoming clear how the respiratory system-when undergoing a chronic oxidative stress-can release slowly, but steadily, a huge number of toxic compounds that are able to enter the circulation and cause serious damage [6]. Moreover, the potent antioxidant capacity of blood exposed to a small and precisely calculated dose of ozone only for a few minutes can modulate the endogenous antioxidant system and aids in the control of different pathological conditions [7].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects

Clavo

Rodrı́guez-Esparragón

Rodríguez-Abreu

et al. 2019

Antioxidants

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(1) Background: Cancer is one of the leading causes of mortality worldwide. Radiotherapy and chemotherapy attempt to kill tumor cells by different mechanisms mediated by an intracellular increase of free radicals. However, free radicals can also increase in healthy cells and lead to oxidative stress, resulting in further damage to healthy tissues. Approaches to prevent or treat many of these side effects are limited. Ozone therapy can induce a controlled oxidative stress able to stimulate an adaptive antioxidant response in healthy tissue. This review describes the studies using ozone therapy to prevent and/or treat chemotherapy-induced toxicity, and how its effect is linked to a modification of free radicals and antioxidants. (2) Methods: This review encompasses a total of 13 peer-reviewed original articles (most of them with assessment of oxidative stress parameters) and some related works. It is mainly focused on four drugs: Cisplatin, Methotrexate, Doxorubicin, and Bleomycin. (3) Results: In experimental models and the few existing clinical studies, modulation of free radicals and antioxidants by ozone therapy was associated with decreased chemotherapy-induced toxicity. (4) Conclusions: The potential role of ozone therapy in the management of chemotherapy-induced toxicity merits further research. Randomized controlled trials are ongoing.

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Section: Modulation Of Oxidative Stress By Ozone Therapymentioning

confidence: 89%

Section: Ozone and Cisplatin-induced Toxicitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects

Clavo

Rodrı́guez-Esparragón

Rodríguez-Abreu

et al. 2019

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Experimental results demonstrated that ozone at therapeutic dosages ex vivo or in vivo can activate Nrf2 [20,32] that involve an indirect modulation (inhibition) of the NF-κB pathway. In addition, Nrf2 suppresses NF-κB activity by eliminating ROS, which may cause NF-κB activation via antioxidative protein induction, such as HO-1 and NQO1.…”

Section: Ozone Therapy As Redox Modulatormentioning

confidence: 99%

Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19

2020

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1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease in China at the end of 2019 has caused a large global outbreak. Systemic ozone therapy (OT) could be potentially useful in the clinical management of several complications secondary to SARS-CoV-2. The rationale and mechanism of action has already been proven clinically in other viral infections and has been shown in research studies to be highly effective at decreasing organ damage mediated by inflammation and oxidative stress. This review summarizes the OT studies that illustrate the possible cytoprotective mechanism of action of ozone and its physiological by-products in target organs affected by SARS-CoV-2. (2) Methods: This review encompasses a total of 74 peer-reviewed original articles. It is mainly focused on ozone as a modulator of the NF-κB/Nrf2 pathways and IL-6/IL-1β expression. (3) Results: In experimental models and the few existent clinical studies, homeostasis of the free radical and antioxidant balance by OT was associated with a modulation of NF-κB/Nrf2 balance and IL-6 and IL-1β expression. These molecular mechanisms support the cytoprotective effects of OT against tissue damage present in many inflammatory diseases, including viral infections. (4) Conclusions: The potential cytoprotective role of OT in the management of organ damage induced by COVID-19 merits further research. Controlled clinical trials are needed.

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“…The NF-κB pathway activation can also upregulate angiogenesis-related factor expression, such as VEGF, and promote the metastasis and invasion of cancer [67,68]. The Nrf2 pathway can generate detoxification and antioxidant effects [69]. The regulation of these pathways by quinonoids may be the main mechanism of their antilung cancer effects.…”

Section: Discussionmentioning

confidence: 99%

Quinonoids: Therapeutic Potential for Lung Cancer Treatment

Ying

Chen

et al. 2020

BioMed Research International

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Lung cancer is the leading cause of cancer-related deaths worldwide. Owing to its high incidence and mortality, the development and discovery of novel anticancer drugs is of great importance. In recent years, many breakthroughs have been achieved in the search for effective anticancer substances from natural products. Many anticancer drugs used clinically and proven to be effective are derived from natural products. Quinonoids, including naphthoquinones, phenanthrenequinones, benzoquinones, and anthraquinones, constitute a large group of natural bioactive compounds that widely exist in higher and lower plant species. Given that most of these compounds possess anticancer effects, they are applied in many cancer studies, especially in lung cancer research. They can promote apoptosis, induce autophagy, and inhibit proliferation, angiogenesis, and cell invasion and migration. Some drugs can enhance anticancer effects when combined with other drugs. Thus, quinonoids have broad application prospects in the treatment of lung cancer. Here, we summarize the previous studies on the antilung cancer activities of quinonoids together with their underlying mechanisms and analyze the common research targets with different effects so as to provide references for the discovery of quinonoids against lung cancer.

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The Role of Nrf2 in the Antioxidant Cellular Response to Medical Ozone Exposure

Cited by 97 publications

References 155 publications

Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects

Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects

Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19

Quinonoids: Therapeutic Potential for Lung Cancer Treatment

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