The role of Notch signaling pathway in metabolic bone diseases

Gao, Yongguang; Fu, Zhentao; Guan, Junxia; Liu, Xinhua; Zhang, Qing

doi:10.1016/j.bcp.2022.115377

Cited by 8 publications

(6 citation statements)

References 114 publications

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“…As a critical organ in the growth axis, changes in the expression of growth regulators in the liver may affect spinal development , Decreased expression of these three mRNAs may be a key factor in spinal dysplasia. CSL , IGF-1 , and NGS are key regulators of osteoblast differentiation, bone growth, and notochord development in fish liver tissues, respectively. , The expression of these genes in the HL group was significantly lower than that in other groups, indicating that abnormal development of the marine medaka spine may be affected by liver regulation in the early stage.…”

Section: Discussionmentioning

confidence: 99%

Conversion of Retinoids along the Marine Food Chain Contributes to Adverse Impacts on the Spine, Liver, and Intestinal Health of the Marine Medaka (Oryzias melastigma)

Liu,

Xie,

Xiao

et al. 2024

Environ. Sci. Technol.

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Marine microalgae serve as an aquaculture bait. To enhance algal cell growth and breeding profits, high-intensity light conditions are standard for cultivating bait microalgae, potentially altering microalgal metabolite production. This research revealed that Thalassiosira pseudonana, when subjected to high-intensity light conditions, accumulated significant quantities of retinal (RAL) that transferred through the food chain and transformed into alltrans retinoic acid (atRA) in marine medaka. The study further explored the toxic effects on individual fish and specific tissues, as well as the mechanisms behind this toxicity. The accumulation of atRA in the liver, intestine, and spinal column resulted in structural damage and tissue inflammation, as well as oxidative stress. It also down-regulated the gene transcription levels of key pathways involved in immune function and growth. Furthermore, it disrupted the homeostasis of the intestinal microbial communities. The implications for wildlife and human health, which are influenced by the regulation of microalgal metabolite accumulation and their transfer via the food chain, require further investigation and could hold broader significance.

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Section: Discussionmentioning

confidence: 99%

Conversion of Retinoids along the Marine Food Chain Contributes to Adverse Impacts on the Spine, Liver, and Intestinal Health of the Marine Medaka (Oryzias melastigma)

Liu,

Xie,

Xiao

et al. 2024

Environ. Sci. Technol.

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“…Notch1 is involved in regulating synaptic activity [ 31 ], Notch2 induces various intracellular responses associated with neuropathic pain [ 32 ], and Notch3 is associated with the differentiation and maturation of spinal cord neurons [ 33 ], the precise mechanisms require further investigation. All Notch receptors consist of three regions: the extracellular region (NEC), the transmembrane region (TM), and the intracellular region (NICD/ICN) [ 19 , 26 , 34 , 35 ].…”

Section: Notch Signaling Pathwaymentioning

confidence: 99%

“…Notch1 and Notch2 possess the transcriptional activation domain (TAD), which is absent in Notch3 and Notch4. The NICD domain serves as the active form of the Notch receptor, and it’s binding to transcriptional activators initiates the activation of Notch target genes [ 19 ].…”

Section: Notch Signaling Pathwaymentioning

confidence: 99%

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Notch signaling pathway: a new target for neuropathic pain therapy

Wang

Tang

et al. 2023

J Headache Pain

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The Notch gene, a highly evolutionarily conserved gene, was discovered approximately 110 years ago and has been found to play a crucial role in the development of multicellular organisms. Notch receptors and their ligands are single-pass transmembrane proteins that typically require cellular interactions and proteolytic processing to facilitate signal transduction. Recently, mounting evidence has shown that aberrant activation of the Notch is correlated with neuropathic pain. The activation of the Notch signaling pathway can cause the activation of neuroglia and the release of pro-inflammatory factors, a key mechanism in the development of neuropathic pain. Moreover, the Notch signaling pathway may contribute to the persistence of neuropathic pain by enhancing synaptic transmission and calcium inward flow. This paper reviews the structure and activation of the Notch signaling pathway, as well as its potential mechanisms of action, to provide novel insights for future treatments of neuropathic pain.

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“…The differentiation of MSCs into osteoblasts involves the activation of many signaling pathways,including the WNT,TGFβ,and Notch signaling pathways [56][57],with the most important being the Notch signaling pathway [37] [60].Evidence has shown that the Notch signaling pathway is associated with skeletal developmental defects,such as Hajdu-Cheney syndrome [38][57][58] [59].Furthermore, there is evidence that the absence of Jag1 and Notch leads to osteoporosis in adult mice [39], [40].In this study,we successfully established a model of ZIKV infection in hiPSCs-hNCCs and hNCC-MSCs,as well as a model of ZIKV infection in pregnant C57 BL/6 female mice,with the aim to investigate the impact of ZIKV on the osteogenic differentiation ability of hNCC-MSCs and the role of the Notch signaling pathway in this process…”

Section: Introductionmentioning

confidence: 99%

Effect of Zika virus on the osteogenic capacity of mesenchymal stem cells via the Notch signaling pathway

Li,

Gao,

Shi

et al. 2024

Preprint

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Background: Zika virus is a small enveloped flavivirus transmitted through the bite of the aedes mosquitos. Epidemiologic survey has shown that diseases caused by Zika virus mainly include microcephaly and malformation of cranial bones.In 2016, nucleic acid screening for the zika virus was conducted in Puerto Rico, and the results indicated that the seasonal incidence rate of zika virus could reach 21.1%. Research Purpose: To investigate the effect of zika virus on the osteogenic capacity of mesenchymal stem cells. Method: We induced the zika virus-infected human mesenchymal stem cells into osteoblasts. Real-time quantitative polymerase chain reaction and Western Blot were used to detect the mRNA and protein expression of the osteogenic markers, as well as notch signaling pathway molecules. A γ-secretase inhibitor was used to explore whether the osteogenic ability of Zika virus-infected mesenchymal stem cells is restored after inhibiting the notch signaling pathway. Establish a mouse model to verify the results in vivo. Result: We found that zika virus activated the Notch signaling pathway in mesenchymal stem cells,hindering the formation of osteoblasts. After treating mesenchymal stem cells with the gamma-secretase inhibitor,the osteogenic ability of mesenchymal stem cells can be restored. The same results were observed in the mouse model. Conclusion: Zika virus suppresses the osteogenic capacity of mesenchymal stem cells via notch signaling pathway.

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The role of Notch signaling pathway in metabolic bone diseases

Cited by 8 publications

References 114 publications

Conversion of Retinoids along the Marine Food Chain Contributes to Adverse Impacts on the Spine, Liver, and Intestinal Health of the Marine Medaka (Oryzias melastigma)

Conversion of Retinoids along the Marine Food Chain Contributes to Adverse Impacts on the Spine, Liver, and Intestinal Health of the Marine Medaka (Oryzias melastigma)

Notch signaling pathway: a new target for neuropathic pain therapy

Effect of Zika virus on the osteogenic capacity of mesenchymal stem cells via the Notch signaling pathway

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