The role of nonesterified fatty acids in pathogenesis of cardiovascular diseases

Tsvetkova, Milena; Хирманов, В. Н.; Зыбина, Н. Н.

doi:10.18705/1607-419x-2010-16-1-93-103

Cited by 10 publications

(8 citation statements)

References 131 publications

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“…Проведенные ранее исследования у пациентов СД демонстрируют наличие у данной когорты больных синдрома нарушения утилизации жирных кислoт, в результате которого происходит накопление в крови неэстерифицированных жирных кислот (НЭЖК) при одновременном снижении уровня глицерола [8,9]. Повышение уровня НЭЖК с развитием нарушения их утилизации миокардом в условиях выраженной симпатикотонии, стресса и электролитных нарушений у больных с ДКА, вероятно, реализует их детергентное действие на мембраны кардиомиоцитов с развитием электрической нестабильности миокарда и формированием нарушений ритма сердца у данной категории больных [4,6,8].…”

Section: Discussionunclassified

Structural and functional myocardial abnormalities and arrhythmias in patients with type 1 diabetes complicated with ketoacidosis

et al. 2020

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Aim. To study the structural and functional cardiac changes and arrhythmias in patients with type 1 diabetes (T1D) complicated with ketoacidosis.Material and methods. We analyzed 24-hour Holter monitoring data in 112 patients with T1D complicated with diabetic ketoacidosis (DKA). To assess the left ventricular (LV) diastolic function, all patients underwent echocardiography.Results. In patients with T1D complicated with DKA, the following cardiac arrhythmias were recorded: supraventricular arrhythmias — 60,7%, premature ventricular contractions — 26,2%, premature ventricular and supraventricular contractions — 13,1%. In 30% of patients with T1D complicated with DKA, premature ventricular contractions were classified as class 4A, in 10% — class 4B. With severe DKA, 5% of patients had short runs of unstable ventricular tachycardia. As the severity of ketosis increases, myocardial remodeling and LV diastolic dysfunction are recorded, as well as the spectral and temporal parameters of heart rate variability decrease.Conclusion. In patients with T1D complicated with DKA, structural and functional LV abnormalities, the development of LV diastolic dysfunction and cardiac arrhythmias are more often recorded. The most pronounced changes were found in the group of patients with T1D with moderate and severe DKA.

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Section: Discussionunclassified

Structural and functional myocardial abnormalities and arrhythmias in patients with type 1 diabetes complicated with ketoacidosis

et al. 2020

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“…Normally, they are contained in blood plasma in an amount of 0.3–0.9 mmol/L in the form of a complex with albumin. A short‐term increase in their blood content is possible with intense physical activity, starvation and stress, and a long‐term with pheochromocytoma, hyperthyroidism, alcoholism, liver failure, Type 2 diabetes mellitus, metabolic syndrome and obesity (Tsvetkova et al, 2010). Elevated FFAs in blood plasma are a risk factor for cardiovascular diseases (Ghosh et al, 2017).…”

Section: Endogenous Substances That Disrupt the Functions Of The Vementioning

confidence: 99%

Endogenous humoral determinants of vascular endothelial dysfunction as triggers of acute poisoning complications

Ivnitsky

Schäfer²,

Rejniuk

et al. 2022

J of Applied Toxicology

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The vascular endothelium is not only the semipermeable membrane that separates tissue from blood but also an organ that regulates inflammation, vascular tone, blood clotting, angiogenesis and synthesis of connective tissue proteins. It is susceptible to the direct cytotoxic action of numerous xenobiotics and to the acute hypoxia that accompanies acute poisoning. This damage is superimposed on the preformed state of the vascular endothelium, which, in turn, depends on many humoral factors. The probability that an exogenous toxicant will cause lifethreatening dysfunction of the vascular endothelium, thereby complicating the course of acute poisoning, increases with an increase in the content of endogenous substances in the blood that disrupt endothelial function. These include ammonia, bacterial endotoxin, indoxyl sulfate, para-cresyl sulfate, trimethylamine N-oxide, asymmetric dimethylarginine, glucose, homocysteine, low-density and very-lowdensity lipoproteins, free fatty acids and products of intravascular haemolysis. Some other endogenous substances (albumin, haptoglobin, haemopexin, biliverdin, bilirubin, tetrahydrobiopterin) or food-derived compounds (ascorbic acid, rutin, omega-3 polyunsaturated fatty acids, etc.) reduce the risk of lethal vascular endothelial dysfunction. The individual variability of the content of these substances in the blood contributes to the stochasticity of the complications of acute poisoning and is a promising target for the risk reduction measures. Another feasible option may be the repositioning of drugs that affect the function of the vascular endothelium while being currently used for other indications.

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“…В связи с этим необходима оптимизация жирового состава рациона. Во многих эпидемиологических исследованиях выявлена прямая связь между потреблением НЖК и уровнем АД и установлена обратная связь между потреблением ПНЖК и МНЖК и уровнем АД [101].…”

Section: жирнокислотный состав рациона и агunclassified

Russian Society for the Prevention of Noncommunicable Diseases (ROPNIZ). Alimentary-dependent risk factors for chronic non-communicable diseases and eating habits: dietary correction within the framework of preventive counseling. Methodological Guidelines

Драпкина¹,

Карамнова²,

Концевая³

et al. 2021

Cardiovasc Ther Prev

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The methodological guidelines are developed as a practical document for medical specialists working in the field of preventive medicine, in order to expand and improve the provision of this type of medical service to the adult population. The methodological guidelines include an informational and informative part for medical specialists and a practical part for patients, presented in the format of memos, contain the main sections-healthy nutrition, correction of eating habits, issues of modifying the diet for the main alimentary-dependent risk factors for chronic non-communicable diseases, such as arterial hypertension, obesity, disorders of lipid, carbohydrate and purine metabolism, a decrease in bone mineral density. They are intended for medical specialists working in the field of prevention, for doctors and secondary medical personnel of offices and departments of medical prevention, public health and medical prevention centers, healthy lifestyle specialists, teachers of medical educational institutions, for specialists who develop and implement educational programs for patients, as well as for medical specialists of a therapeutic profile.

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The role of nonesterified fatty acids in pathogenesis of cardiovascular diseases

Cited by 10 publications

References 131 publications

Structural and functional myocardial abnormalities and arrhythmias in patients with type 1 diabetes complicated with ketoacidosis

Structural and functional myocardial abnormalities and arrhythmias in patients with type 1 diabetes complicated with ketoacidosis

Endogenous humoral determinants of vascular endothelial dysfunction as triggers of acute poisoning complications

Russian Society for the Prevention of Noncommunicable Diseases (ROPNIZ). Alimentary-dependent risk factors for chronic non-communicable diseases and eating habits: dietary correction within the framework of preventive counseling. Methodological Guidelines

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