The Role of Non-Pharmacological Treatment for Osteoporosis at Patients with High Plasmatic Concentration of ACTH

Abstract

Cushing disease is characterized by the hypersecretion of adrenocorticotropic hormone (ACTH) due to a pituitary adenoma that causes endogenous hypercortisolism by stimulating adrenal glands. Objective of the study was to analyse the benefits of the physical therapy for patients with ACTH-secreting adenomas osteoporosis.This retrospective study was performed at Craiova, Bunavestire Hospital, the patients were monitorized during 6 months and included 17 patients with ACTH-secretingadenomas. Participants in this study group exercised 3 days a week for 6 consecutive months. Each session is intended to take approximately 60 minutes to complete and will comprise of a warm-up, progressive resistance training using medium weights, moderate impact weight-bearing exercises, flexibility and also stretching exercises. Physical therapy for osteoporosis treatment in patients with ACTH-secreting adenomas improved joint mobility and reduced pain, significantly increasing BMD performed by DEXA in group I patients compared to patients included in group II. Pain relief is evident following evaluation using the VAS rating scale. The increase in joint mobility is observed following the goniometric measurement from day 1 to the end of treatment. Applying the physical therapy program the bone pain and joint mobility was improved, physical therapy can modify bone turnover in the sense of increasing the body mass.