The role of non-invasive scores in determining the liver fibrosis in NAFLD and psoriatic patients

Neagoe, Carmen Daniela; Farmazon, Anca Smaranda; Amzolini, Anca Maria; Singer, Cristina Elena; Ianoși, Simona Laura; Tutunaru, Cristina Violeta; Genunche-Dumitrescu, Amelia; Ianoşi, Nicolae Gabriel; Păun, I; Leru, Polliana Mihaela; Tica, Oana Sorina; Popescu, Mihaela

doi:10.47162/rjme.61.2.20

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…Molecular studies have provided important insights into the pathogenesis of this relatively common condition. One of the most important advances has been the identification of the links between obesity, insulin resistance, inflammation and NAFLD [ 20 , 21 ]. Data from the literature have shown that insulin resistance and its hepatic consequence, NAFLD, could be the result of widespread inflammation [ 22 ].…”

Section: ⧉ Discussionmentioning

confidence: 99%

Systemic and adipose tissue inflammation in NASH: correlations with histopathological aspects

Micu

Amzolini²,

Abu-Alhija³

et al. 2022

Rom J Morphol Embryol

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Introduction: Non-alcoholic steatohepatitis (NASH) is a progressive form of liver steatosis that involves a risk of progression towards fibrosis, cirrhosis, and end-stage liver disease. Low-grade inflammation is recognized to be involved in non-alcoholic fatty liver disease (NAFLD) pathogeny. Additionally, adipose tissue dysfunction plays an important role in the development of metabolic diseases. Patients, Materials and Methods:We conducted a study on 68 patients with liver steatosis confirmed through liver biopsy during the surgery. In all the patients, we recorded anthropometric parameters and we performed blood tests for systemic inflammation [high-sensitivity C-reactive protein (hs-CRP), fibrinogen] and serum adipokines related to adipose tissue inflammation (leptin, adiponectin). Additional to histopathological examination, we also performed the immunohistochemical study of inflammatory mononuclear cells. Results: The 68 patients had a mean age of 56.57±4.94 years old, had a mean value of hs-CRP of 2.30±0.91 mg/L, a mean value of leptin of 14.02±17.02 ng/mL and a mean value of adiponectin of 7.54±0.38 mg/L. In all the cases studied by liver biopsy, the steatosis exceeded 5% of hepatocytes, but the frequency of NASH was 26.47%. Cluster of differentiation (CD)45-positive, CD4-positive, and CD8-positive T-lymphocytes predominated in the studied cases. We obtained a statistically significant high association between definite NASH and the values of hs-CRP, serum adiponectin and leptin/adiponectin ratio (p<0.0001). Conclusions: Systemic and adipose tissue inflammation was statistically significant associated with histological lesions of steatosis and NASH, suggesting that the determination of hs-CRP and serum adipokines in dynamics in patients with NAFLD is predictive for the progression of the disease.

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Section: ⧉ Discussionmentioning

confidence: 99%

Systemic and adipose tissue inflammation in NASH: correlations with histopathological aspects

Micu

Amzolini²,

Abu-Alhija³

et al. 2022

Rom J Morphol Embryol

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“…In general, ALT and AST values are not much higher than the reference values (on average, 2–3 times the threshold value), with an ALT–AST ratio above one [ 65 ]. An interesting aspect observed in a study conducted in Romania in 2020 was that patients who only have NAFLD have lower AST/ALT and fibrosis scores than patients who have concurrent psoriasis [ 83 ]. This demonstrates that the association between NAFLD and psoriasis leads to an unfavorable prognosis in the evolution of liver disease.…”

Section: Correlation Between Psoriasis and Nafldmentioning

confidence: 99%

Intersecting Pathways: Nonalcoholic Fatty Liver Disease and Psoriasis Duet—A Comprehensive Review

Costache,

Blejan,

Cojocaru

et al. 2024

IJMS

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Psoriasis is a chronic, immune-mediated, inflammatory disease that has a major impact on patients’ quality of life. Common psoriasis-associated comorbidities include cardiovascular diseases, psoriatic arthritis, inflammatory bowel syndromes, type-2 diabetes, and metabolic syndrome. Nonalcoholic fatty liver disease (NAFLD) is affecting a substantial portion of the population and is closely linked with psoriasis. The interplay involves low-grade chronic inflammation, insulin resistance, and genetic factors. The review presents the pathophysiological connections between psoriasis and nonalcoholic fatty liver disease, emphasizing the role of cytokines, adipokines, and inflammatory cascades. The “hepato-dermal axis” is introduced, highlighting how psoriatic inflammation potentiates hepatic inflammation and vice versa. According to the new guidelines, the preliminary examination for individuals with psoriasis should encompass evaluations of transaminase levels and ultrasound scans as part of the initial assessment for this cohort. Considering the interplay, recent guidelines recommend screening for NAFLD in moderate-to-severe psoriasis cases. Treatment implications arise, particularly with medications impacting liver function. Understanding the intricate relationship between psoriasis and NAFLD provides valuable insights into shared pathogenetic mechanisms. This knowledge has significant clinical implications, guiding screening practices, treatment decisions, and the development of future therapeutic approaches for these chronic conditions.

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Blood-based scoring systems for identifying significant liver fibrosis in patients with psoriasis

Chularojanamontri

Panjapakkul

Chaiyabutr

et al. 2023

British Journal of Dermatology

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The role of non-invasive scores in determining the liver fibrosis in NAFLD and psoriatic patients

Cited by 5 publications

References 34 publications

Systemic and adipose tissue inflammation in NASH: correlations with histopathological aspects

Systemic and adipose tissue inflammation in NASH: correlations with histopathological aspects

Intersecting Pathways: Nonalcoholic Fatty Liver Disease and Psoriasis Duet—A Comprehensive Review

Blood-based scoring systems for identifying significant liver fibrosis in patients with psoriasis

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