The role of non-coding RNAs (miRNA and lncRNA) in the clinical management of rheumatoid arthritis

Yang, Jiujie; Li, Zhi; Wang, Linna; Yun, Xiaoyun; Zeng, Yaling; Ng, Jerome P.L.; Lo, Hanghong; Wang, Yan; Zhang, Kaixi; Law, Betty Yuen Kwan; Wong, Vincent Kam Wai

doi:10.1016/j.phrs.2022.106549

Cited by 18 publications

(6 citation statements)

References 182 publications

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“…CircRNA can sponge miRNAs to regulate mRNA transcription, as shown in rheumatoid arthritis and systemic lupus erythematosus (SLE) [30]. LncRNA may also sponge miRNA and regulate DNA transcription, with relevance in rheumatoid arthritis [31]; (iii) DNA methyltransferase (DNMT) and ten eleven translocation (TET) modulate gene transcription via the hypermethylation and hypomethylation of cytosine in DNA, respectively. DNMT-1 is proposed to regulate immune responses, as shown in Graves' disease [32], whilst Tet methylcytosine dioxygenase 2 (Tet2) deficiency drives hepatic microbiome dysbiosis, leading to CD8 + T cell-mediated autoimmune hepatitis [33]; (iv) N 6 -methyladenosine (m 6 A) is a common modification of both mRNA and DNA, whereby the METTL3/METTL14 methyltransferase complex installs m 6 A onto mRNA, which can impact not only translation, but also nuclear export and decay, as well as pre-mRNA processing, with relevance to immune regulation in T1DM [34].…”

Section: Classical Autoimmunitymentioning

confidence: 99%

Redefining Autoimmune Disorders’ Pathoetiology: Implications for Mood and Psychotic Disorders’ Association with Neurodegenerative and Classical Autoimmune Disorders

Anderson¹,

Almulla

Reíter

et al. 2023

Cells

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Although previously restricted to a limited number of medical conditions, there is a growing appreciation that ‘autoimmune’ (or immune-mediated) processes are important aspects of a wide array of diverse medical conditions, including cancers, neurodegenerative diseases and psychiatric disorders. All of these classes of medical conditions are associated with alterations in mitochondrial function across an array of diverse cell types. Accumulating data indicate the presence of the mitochondrial melatonergic pathway in possibly all body cells, with important consequences for pathways crucial in driving CD8+ T cell and B-cell ‘autoimmune’-linked processes. Melatonin suppression coupled with the upregulation of oxidative stress suppress PTEN-induced kinase 1 (PINK1)/parkin-driven mitophagy, raising the levels of the major histocompatibility complex (MHC)-1, which underpins the chemoattraction of CD8+ T cells and the activation of antibody-producing B-cells. Many factors and processes closely associated with autoimmunity, including gut microbiome/permeability, circadian rhythms, aging, the aryl hydrocarbon receptor, brain-derived neurotrophic factor (BDNF) and its receptor tyrosine receptor kinase B (TrkB) all interact with the mitochondrial melatonergic pathway. A number of future research directions and novel treatment implications are indicated for this wide collection of poorly conceptualized and treated medical presentations. It is proposed that the etiology of many ‘autoimmune’/‘immune-mediated’ disorders should be conceptualized as significantly determined by mitochondrial dysregulation, with alterations in the mitochondrial melatonergic pathway being an important aspect of these pathoetiologies.

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Section: Classical Autoimmunitymentioning

confidence: 99%

Redefining Autoimmune Disorders’ Pathoetiology: Implications for Mood and Psychotic Disorders’ Association with Neurodegenerative and Classical Autoimmune Disorders

Anderson¹,

Almulla

Reíter

et al. 2023

Cells

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“…Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease characterized by erosive and polyarthritis as the main clinical manifestations [92] . The presence or absence of autoantibodies like anticyclic citrullinated peptide (CCP) and rheumatoid factor (RF) have been suggested to be adequate to classify different RA subtypes [93] . Due to its complex pathogenesis and subtle clinical features, early diagnosis of RA is challenging to achieve.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

lncRNA involvement in immune-related diseases - from SNP association to implication in pathogenesis and therapeutic potential

Bergara-Muguruza,

Castellanos-Rubio,

Santin

et al. 2023

J Transl Genet Genom

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Development of new high throughput array-based techniques and, more recently, next-generation sequencing (NGS) technologies have revolutionized our capability to accurately characterize single nucleotide polymorphisms (SNPs) throughout the genome. These advances have facilitated large-scale genome-wide association studies (GWAS), which have served as fundamental elements in establishing links between SNPs and the susceptibility to several complex diseases, including those related to the immune system. Nevertheless, the molecular mechanisms underlying the development of most of these disorders are still poorly defined. Decoding the functionality of SNPs becomes increasingly challenging due to the predominant presence of these risk variants in non-coding regions of the genome. Among them, long non-coding RNAs (lncRNAs) are enriched in disease-associated SNPs. lncRNAs are involved in governing the control of gene expression both during transcription and at the post-transcriptional level. The existence of SNPs within the sequences of lncRNAs has the potential to alter their expression, structure, or function. This, in turn, can influence their regulatory roles and consequently contribute to the onset or progression of various diseases. In this review, we describe the implication of SNPs located in lncRNAs in the development of different immune-related diseases and highlight the potential of these molecules in the development of emerging RNA-based therapies.

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“…Although miRNA-21 is nonspecificity, it is regarded as a versatile regulator in the advancement of CNS disorders. It is believed to have both harmful and beneficial effects ( Garcia et al, 2022 ; Yang et al, 2022 ; Huang et al, 2024 ). In both in vitro and in vivo , miRNA-21 has been linked to the control of Aβ oligomer-induced toxicity ( Xie et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Investigating the potential neuroprotective benefits of taurine and Dihydrotestosterone and Hydroxyprogesterone levels in SH-SY5Y cells

Almohaimeed,

Almars,

Alsulaimani

et al. 2024

Front. Aging Neurosci.

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BackgroundTaurine, an amino acid abundantly found in the brain and other tissues, has potential neuroprotective properties. Alzheimer’s disease (AD) is a commonly occurring type of dementia, which becomes more prevalent as people age. This experiment aimed to assess the neuroprotective effects of taurine on SH-SY5Y cells by examining its impact on Dihydrotestosterone (DHT), Dihydroprogesterone (DHP), as well as the expression of miRNA-21 and miRNA-181.MethodsThe effects of various taurine concentrations (0.25, and 0.75 mg/mL), and LPS (0.1, and 12 mg/mL) on the SH-SY5Y cell line were assessed using the MTT assay. The levels of DHT and DHP were quantified using an ELISA kit. Additionally, the expression levels of miRNA-181 and miRNA-21 genes were examined through Real-Time PCR analysis.ResultsThe results of the MTT assay showed that treatment with taurine at concentrations of 0.25, and 0.75 mg/mL reduces the toxicity of LPS in SH-SY5Y cells. ELISA results indicated that taurine at a concentration of 0.25, and 0.75 mg/mL significantly elevated DHT and DHP hormones in the SH-SY5Y cell line compared to the untreated group (p < 0.01). The expression levels of IL-1β and IL-6 were decreased under the influence of LPS in SH-SY5Y cells after taurine treatment (p < 0.01). Gene expression analysis revealed that increasing taurine concentration resulted in heightened expression of miRNA-181 and miRNA-21, with the most significant increase observed at a concentration of 0.75 mg/mL (p < 0.001).ConclusionOur study findings revealed that the expression of miRNA-181 and miRNA-21 can be enhanced by taurine. Consequently, exploring the targeting of taurine, miRNA-181, and miRNA-21 or considering hormone therapy may offer potential therapeutic approaches for treating AD or alleviating severe symptoms. Nonetheless, in order to fully comprehend the precise mechanisms involved, additional research is required.

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The role of non-coding RNAs (miRNA and lncRNA) in the clinical management of rheumatoid arthritis

Cited by 18 publications

References 182 publications

Redefining Autoimmune Disorders’ Pathoetiology: Implications for Mood and Psychotic Disorders’ Association with Neurodegenerative and Classical Autoimmune Disorders

Redefining Autoimmune Disorders’ Pathoetiology: Implications for Mood and Psychotic Disorders’ Association with Neurodegenerative and Classical Autoimmune Disorders

lncRNA involvement in immune-related diseases - from SNP association to implication in pathogenesis and therapeutic potential

Investigating the potential neuroprotective benefits of taurine and Dihydrotestosterone and Hydroxyprogesterone levels in SH-SY5Y cells

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