The role of non-biting flies in the transmission of enteric pathogens<i>(Salmonella</i>species and<i>Shigella</i>species) in Beirut, Lebanon

Bidawid, Sabah; Edeson, J. F. B.; Ibrahim, J.; Matossian, R. M.

doi:10.1080/00034983.1978.11719291

Cited by 42 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unlike humans, mice do not develop intestinal disease upon ingestion of S. flexneri. While recent developments of mouse models using newborn mice (17) and infection paired with intraluminal injection of interleukin-8 (34) are promising, their utility in the study of host cell factors involved in shigellosis remains to be determined.Although Shigella is believed to specifically infect primates, several reports indicate that invertebrates, such as flies and nematodes, may serve as vectors of the bacterium (5,12,16,25,28,41,42). These results indicate that the host range of the pathogen may be broader than is suspected and open the possibility of using invertebrates to study conserved hostpathogen interactions that can be translated to mammalian systems.…”

mentioning

confidence: 71%

“…Although Shigella is believed to specifically infect primates, several reports indicate that invertebrates, such as flies and nematodes, may serve as vectors of the bacterium (5,12,16,25,28,41,42). These results indicate that the host range of the pathogen may be broader than is suspected and open the possibility of using invertebrates to study conserved hostpathogen interactions that can be translated to mammalian systems.…”

mentioning

confidence: 71%

“…Human enteric pathogens have been found to be associated with free-living nematodes (41,42), and C. elegans has been suggested to transport Salmonella to fruits and vegetables (11,24). It is known that Shigella gets in contact with invertebrates such as flies (5,16,25,28) and that it is ingested and defecated by free-living saprozoic nematodes (12). Thus, although the interaction between C. elegans and S. flexneri in the petri dish is artificially caused, the interaction between the two organisms may take place in nature.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Caenorhabditis elegans ABL-1 Tyrosine Kinase Is Required for Shigella flexneri Pathogenesis

Burton

Pendergast

Aballay³

2006

Appl Environ Microbiol

View full text Add to dashboard Cite

Shigellosis is a diarrheal disease caused by the gram-negative bacterium Shigella flexneri. Following ingestion of the bacterium, S. flexneri interferes with innate immunity, establishes an infection within the human colon, and initiates an inflammatory response that results in destruction of the tissue lining the gut. Examination of host cell factors required for S. flexneri pathogenesis in vivo has proven difficult due to limited host susceptibility. Here we report the development of a pathogenesis system that involves the use of Caenorhabditis elegans as a model organism to study S. flexneri virulence determinants and host molecules required for pathogenesis. We show that S. flexneri-mediated killing of C. elegans correlates with bacterial accumulation in the intestinal tract of the animal. The S. flexneri virulence plasmid, which encodes a type III secretory system as well as various virulence determinants crucial for pathogenesis in mammalian systems, was found to be required for maximal C. elegans killing. Additionally, we demonstrate that ABL-1, the C. elegans homolog of the mammalian c-Abl nonreceptor tyrosine kinase ABL1, is required for S. flexneri pathogenesis in nematodes. These data demonstrate the feasibility of using C. elegans to study S. flexneri pathogenesis in vivo and provide insight into host factors that contribute to S. flexneri pathogenesis.The gram-negative bacterium Shigella flexneri is the causative agent of shigellosis, a diarrheal disease which affects up to 150 million people annually (22). The study of shigellosis in vivo has been hampered by the lack of a suitable model system. Unlike humans, mice do not develop intestinal disease upon ingestion of S. flexneri. While recent developments of mouse models using newborn mice (17) and infection paired with intraluminal injection of interleukin-8 (34) are promising, their utility in the study of host cell factors involved in shigellosis remains to be determined.Although Shigella is believed to specifically infect primates, several reports indicate that invertebrates, such as flies and nematodes, may serve as vectors of the bacterium (5,12,16,25,28,41,42). These results indicate that the host range of the pathogen may be broader than is suspected and open the possibility of using invertebrates to study conserved hostpathogen interactions that can be translated to mammalian systems. Caenorhabditis elegans has become a well-established model invertebrate for the study of bacterial pathogenesis and innate immunity. As in mammals, peristalsis, low pH, lytic enzymes, and antimicrobial substances prevent microbial colonization of the C. elegans intestine. However, pathogenic bacteria are capable of proliferating and killing C. elegans using different mechanisms. The lists of bacterial pathogens that induce nematode killing include both gramnegative pathogens such as Salmonella enterica, Pseudomonas aeruginosa, and Serratia marcescens and gram-positive bacteria such as Streptococcus pneumoniae, Staphylococcus aureus, and Enterococcus faecalis (...

show abstract

mentioning

confidence: 71%

mentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Caenorhabditis elegans ABL-1 Tyrosine Kinase Is Required for Shigella flexneri Pathogenesis

Burton

Pendergast

Aballay³

2006

Appl Environ Microbiol

View full text Add to dashboard Cite

show abstract

“…A legyek, különösen a házilegyek, az enteralis kóroko-zók fontos rezervoárjai, és vektoraiként [38][39][40][41] szezonalitásuk hosszával és fenológiájának jellegzetességével befolyásolhatják az enteralis fertőzések szezonalitását. A teljes nyári időszak, de különösen július második fele és augusztus első fele tekinthető kockázatos periódusnak a légy vektorok szempontjából.…”

Section: áBraunclassified

A campylobacteriosis és a salmonellosis heti átlaghőmérséklet által meghatározott szezonalitásának és az Eristalis tenax (Diptera: Syrphidae) éves fenológiájának összehasonlítása

Tràjer

Schoffhauzer²

2016

Orvosi Hetilap

View full text Add to dashboard Cite

Magyar Tudományos Akadémia-Pannon Egyetem, Limnoökológiai Kutatócsoport, Veszprém 3 független szerzőBevezetés: A környezeti hőmérséklet és a Diptera fajok aktivitása a bakteriális bélfertőzések szezonalitásának legfontosabb faktorai. Célkitűzés: A szerzők tanulmányukban a campylobacteriosis és a salmonellosis incidenciaértékeinek alakulását elemezték a heti átlaghőmérséklet függvényében, összevetve a potenciális vektor Eristalis tenax éves fenológiájával. Módszer: A megbetegedési adatokat az Országos Epidemiológiai Központ epidemiológiai információs hetilapjában közölt adattáblákból nyerték. A Magyarországot lefedő rácsra átlagolt heti átlaghőmérsékleti adatok a "European Climate Assessment Dataset" adatbázisból származtak. Eredmények: A campylobacteriosis-incidencia gyenge (r 2 = 0,39), a salmonellosi-sincidencia erős (r 2 = 0,71) összefüggést mutatott a nyolc héttel korábbi heti átlag-hőmérséklet-értékekkel. Következtetések: Az Eristalis tenax fenológiájának és a tanulmányozott bakteriális bélfertőzé-sek incidenciájának összevetése arra az eredményre vezetett, hogy a Salmonella és Campylobacter fajok átvitele szempontjából elsősorban a késő tavaszi és nyári hónapokban juthat jelentősebb szerep a Diptera fajoknak, különös tekintettel a július és augusztus hónapokra. Orv. Hetil., 2016, 157(14), 529-538. Kulcsszavak: Salmonella-fertőzések, Campylobacter-fertőzések, DipteraComparison of the temperature-driven seasonality of campylobacteriosis and salmonellosis and the annual phenology of Eristalis tenax (Diptera: Syrphidae)Introduction: Ambient temperature and the activity of Diptera species are the primary factors of the seasonality of bacterial enteral diseases. Aim: The authors analyzed the effect of the weekly mean ambient temperature on salmonellosis and campylobacteriosis incidence and the annual phenology of the potential vector Eristalis tenax. Method: Weekly case number data of the period between 2004 and 2014 were derived from the Hungarian National Center for Epidemiology. European Climate Assessment Dataset was the source of the weekly mean temperature data for the grid overlapping Hungary. Results: While in the case of campylobacteriosis weak correlation was found (r 2 = 0.39), salmonellosis showed strong correlation with mean temperature (r 2 = 0.71) using 8-weeks lag before the outbreak of the cases. Conclusions: Comparing the mean weekly incidence of campylobacteriosis and salmonellosis with the modeled weekly activity of Eristalis tenax it was found that vector Diptera species may influence the incidence of enteric diseases in late spring and summer, in July and August particularly.

show abstract

“…Diversas familias de dípteros braquíceros como Muscidae, Fanniidae, Calliphoridae o Sarcophagidae, presentan especies con demostrado papel en la difusión de virus, bacterias y protozoos enteropatógenos [25][26][27][28] .…”

Section: Artrópodos Y Saludunclassified

Artrópodos con interés vectorial en la salud pública en España

Marí¹,

Marí²,

Moscardó³

et al. 2009

Rev. Esp. Salud Publica

View full text Add to dashboard Cite

Quince de las treinta y una Enfermedades de Declaración Obligatoria en España, exceptuando las de tipo congénito o neonatal, pueden ser transmitidas por diversas especies de artrópodos que están presentes en nuestro país. Decenas de bacterias, hongos, virus y protozoos tienen en diversos órdenes de artrópodos a sus agentes transmisores ideales. Este hecho hace que sea necesario conocer su biología para poder adoptar medidas de control que sean eficaces y nos permitan disminuir la incidencia de estas enfermedades. Sin embargo, los estudios epidemiológicos, lejos de quedar únicamente restringidos a las enfermedades que presentan ciclos activos de transmisión en nuestro país, deben adquirir una visión más global, en la que se incluyan también enfermedades alóctonas pero con una elevada probabilidad de que se transmitan a nuestro territorio en el contexto de globalización en el que nos hallamos. De este modo se conseguirá conocer qué factores impiden su presencia actual y dotar a la Red Nacional de Vigilancia Epidemioló-gica de una capacidad predictiva que permita pronosticar la posible llegada de la enfermedad, fortaleciendo a fin de cuentas la Salud Pública española. El objetivo del presente trabajo es llevar a cabo una revisión de la artropodofauna de interés vectorial en España. Se discute la situación actual en nuestro país de algunas de las enfermedades más importantes con transmisión vectorial, así como los factores que pueden determinar su aparición, resurgencia y/o recrudecimiento. El estudio de estos agentes en nuestra Salud Pública resulta imprescindible como un elemento más articulado en la compleja red que toda enfermedad de tipo vectorial conlleva.Palabras clave: Artrópodos. Salud Pública. Epidemiología. España. Vector. Alergia e inmunología. Entomología. ABSTRACT Arthropods With Vectorial Interest in Spanish Public HealthFifteen of the thirty-one Obligatory Communicable Diseases in Spain, exempting those of congenital or neonatal types, can be transmitted by several species of arthropods that are present in our country. Several arthropod orders are the suitable transmitters of tens of bacteria, fungi, virus and protozoa. This fact demands a through of the biology knowledge of these vectors in order to adopt efficient control measures that allow us to reduce the incidence levels of these diseases. Nevertheless, the epidemiological studies shouldn't remain only restricted to the diseases with active transmission cycles in our country. It is necessary to acquire a global vision because of allochton diseases that are perfectly extensible to our territory in the globalization context in which we are situated. All this information is important to know which factors are preventing the disease presence. The aim is to provide the National Epidemiological Surveillance Network with a valuable predictive capacity that allows it to predict the potential arrival of diseases and the consequent strengthening of the spanish Public Health. The goal of this work is to carry out a review of the spanish arthropod fauna wi...

show abstract

The role of non-biting flies in the transmission of enteric pathogens(Salmonellaspecies andShigellaspecies) in Beirut, Lebanon

Cited by 42 publications

References 0 publications

The Caenorhabditis elegans ABL-1 Tyrosine Kinase Is Required for Shigella flexneri Pathogenesis

The Caenorhabditis elegans ABL-1 Tyrosine Kinase Is Required for Shigella flexneri Pathogenesis

A campylobacteriosis és a salmonellosis heti átlaghőmérséklet által meghatározott szezonalitásának és az Eristalis tenax (Diptera: Syrphidae) éves fenológiájának összehasonlítása

Artrópodos con interés vectorial en la salud pública en España

Contact Info

Product

Resources

About