The role of ‘no-touch’ automated room disinfection systems in infection prevention and control

Otter, Jonathan A.; Yezli, Saber; Perl, Trish M.; Barbut, Frédéric; French, Gary

doi:10.1016/j.jhin.2012.10.002

Cited by 126 publications

(132 citation statements)

References 127 publications

(141 reference statements)

Supporting

Mentioning

120

Contrasting

Order By: Relevance

“…53 This may have implications for automated room disinfection systems using UV radiation. 54 To the authors' knowledge, no studies have evaluated the impact of hydrogenperoxide-based automated room disinfection systems against biofilms, although emerging data suggest that liquid hydrogen peroxide, as an oxidizing agent, targets both the biofilm matrix and microbes in the biofilm. 35 Aside from the inactivation of microbes attached to surfaces, the chemical properties of biocides also seem to be important in terms of preventing, promoting or dismantling biofilms.…”

Section: Biocide Susceptibilitymentioning

confidence: 99%

“…Surface-attached cells and biofilms are clearly not the only reason for failures in hospital disinfection, given the difficulty in achieving adequate distribution and contact time using manual methods. 11,13,54,58 However, both reduced biocide susceptibility (Table I) and increasing resilience to physical removal by cleaning are likely to contribute to failures in hospital cleaning. This could partly explain why disinfectants that are effective for the inactivation of planktonic bacteria in laboratory tests are not effective for the eradication of a considerably lower load of the same bacterial species from hospital surfaces.…”

Section: Physical Removalmentioning

confidence: 99%

See 1 more Smart Citation

Surface-attached cells, biofilms and biocide susceptibility: implications for hospital cleaning and disinfection

Otter

Vickery

Walker

et al. 2015

Journal of Hospital Infection

Self Cite

200

114

View full text Add to dashboard Cite

Microbes tend to attach to available surfaces and readily form biofilms, which is problematic in healthcare settings. Biofilms are traditionally associated with wet or damp surfaces such as indwelling medical devices and tubing on medical equipment. However, microbes can survive for extended periods in a desiccated state on dry hospital surfaces, and biofilms have recently been discovered on dry hospital surfaces. Microbes attached to surfaces and in biofilms are less susceptible to biocides, antibiotics and physical stress. Thus, surface attachment and/or biofilm formation may explain how vegetative bacteria can survive on surfaces for weeks to months (or more), interfere with attempts to recover microbes through environmental sampling, and provide a mixed bacterial population for the horizontal transfer of resistance genes. The capacity of existing detergent formulations and disinfectants to disrupt biofilms may have an important and previously unrecognized role in determining their effectiveness in the field, which should be reflected in testing standards. There is a need for further research to elucidate the nature and physiology of microbes on dry hospital surfaces, specifically the prevalence and composition of biofilms. This will inform new approaches to hospital cleaning and disinfection, including novel surfaces that reduce microbial attachment and improve microbial detachment, and methods to augment the activity of biocides against surface-attached microbes such as bacteriophages and antimicrobial peptides. Future strategies to address environmental contamination on hospital surfaces should consider the presence of microbes attached to surfaces, including biofilms.

show abstract

Section: Biocide Susceptibilitymentioning

confidence: 99%

Section: Physical Removalmentioning

confidence: 99%

Surface-attached cells, biofilms and biocide susceptibility: implications for hospital cleaning and disinfection

Otter

Vickery

Walker

et al. 2015

Journal of Hospital Infection

Self Cite

200

114

View full text Add to dashboard Cite

show abstract

“…Presence of chloroxylenol and isopropyl alcohol in dettol [21] and cinnamaldehyde and eugenol in cinnamon oil [22,23] inhibits the growth of bacterial isolates. Although different disinfection strategies including the application of isopropyl alcohol or ethyl alcohol [24,17] and ultraviolet radiation [25] were reported earlier, but ultraviolet radiation [26] is not so effective against a wide array of microbes.…”

Section: Biofilm Formation By Staphylococcus Speciesmentioning

confidence: 99%

Biofilm Formation of Methicillin and Vancomycin Resistant Staphylococcus Species Isolated From Cellular Phones

Pattnaik

Mishra

Mohapatra

et al. 2018

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: The goal of the study was to explore the occurrence of methicillin and vancomycin-resistant Staphylococcus species from cellular phones and preventive measures to avoid contamination. Methods:The issues addressed in this investigation are i) Isolation of bacteria from 70 cellular phones through swab culture method ii) Characterization of the isolates by standard biochemical test iii) Antibiogram pattern study of the isolates iv) Molecular identification of the selected isolate through 16s rDNA sequencing v) Virulence study through biofilm assay vi) Susceptibility of the isolates against commonly used disinfectants and essential oils through disc diffusion.Results: All 70 different cellular phone used in this study harbored 120 isolates of bacteria. Of which, we recorded high incidence of Gram-positive cocci (51.6%) and 22 isolates were identified as Staphylococcus species. Three isolates (52N6, 53N9 and 53N6) were resistant to both methicillin and vancomycin, in addition, showed resistance against several other antibiotics. The strain 53N6 that exhibited multidrug resistance was further identified as Staphylococcus sp. strain CPC53N6 through 16s rDNA sequencing with NCBI accession no. KX858346. Virulence activity of the isolate was observed by its biofilm forming capacity as revealed from SEM imaging and the biofilms were composed of aggregated cocci and fibriform extracellular matrix. All the Staphylococcus isolates, including CPC53N6, were sensitive to disinfectants like dettol and cinnamon (Cinnamon zeylanicum) oil indicating their use as preventive measures. Conclusion:Thus, the methicillin and vancomycin-resistant Staphylococcus species of cellular phones can be decontaminated through cinnamon oil to minimize further transmission.

show abstract

“…He outlined the rationale for considering an NTD system; principally the 'prior room occupancy' data combined with the fact that conventional methods do not reliably eliminate pathogens (Otter et al, 2013b). Several different NTD systems are available (mainly hydrogen peroxide vapour or aerosol, and ultraviolet C or pulsed-xenon), each with advantages and disadvantages (Otter et al, 2013c). Technology can help, but you need to understand the limitations.…”

Section: Medical Stats With Tim Boswellmentioning

confidence: 99%

Infection Prevention 2013 – a potted overview

Otter

2014

Journal of Infection Prevention

View full text Add to dashboard Cite

The role of ‘no-touch’ automated room disinfection systems in infection prevention and control

Cited by 126 publications

References 127 publications

Surface-attached cells, biofilms and biocide susceptibility: implications for hospital cleaning and disinfection

Surface-attached cells, biofilms and biocide susceptibility: implications for hospital cleaning and disinfection

Biofilm Formation of Methicillin and Vancomycin Resistant Staphylococcus Species Isolated From Cellular Phones

Infection Prevention 2013 – a potted overview

Contact Info

Product

Resources

About