The role of nitric oxide in the emotional learning of rats in the plus-maze

Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants

“…In similar antiamnesic activity assays reported so far, which have used the same experimental animal model as ours, in vitro AChE inhibitory and antioxidant activity assays of the extracts have been also employed (Da Cunha et al, 2005;Zhang et al, 2006;Hung et al, 2008;Jeong et al, 2009).…”

Brain nitric oxide: Regional characterisation of a real-time microelectrochemical sensor

“…Other paradigms reported include the elevated plus-maze which is based on exploratory behaviour of rats. NO is believed to play a role in learning and memory and l-NAME is shown to induce a learning deficit in this avoidance learning test (Da Cunha et al, 2005). Since nitric oxide has been characterised as the EDRF, it is very closely associated with CBF and cerebrovasodilation.…”

Original article Involvement of D 2 /D 2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate

“…Animals retested in the EPM avoid exploring open spaces and displaying a clear enclosed arm preference with a low percentage of entries and time spent in the open arms [59], relative to their respective measures during the test [10,22,44,74,79]. The aversive and fear-inducing nature of the open arms represents a useful tool for the study of aversively motivated learning processes in the EPM [16]. Based on the above, learning and memory are usually studied in the EPM through avoidance to open-arms during the retest session.…”