The Role of Nitric Oxide in the Antioxidant Defense of Plants Exposed to UV‐B Radiation

Cassia, Raúl; Amenta, Melina; Fernández, María Belén; Nocioni, Macarena; Dávila, Valeria A.

doi:10.1002/9781119468677.ch22

Cited by 15 publications

(9 citation statements)

References 101 publications

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“…22,23 Indeed, UV-B overexposure even induces oxidative stress in flora, demonstrating the over-arching risk of ROS overproduction due to UV-B. 24 This prevalent oxidative stressinducing ability of UV-B is, therefore, a key point of focus in the search for therapies to mitigate UV-Binduced injury. The results of the present study demonstrate a clear ability of Gpr40 agonism to limit UV-Binduced ROS production.…”

Section: Discussionmentioning

confidence: 99%

<p>Agonism of Gpr40 Protects the Capacities of Epidermal Stem Cells (ESCs) Against Ultraviolet-B (UV-B)</p>

Sun

Li²,

et al. 2020

DDDT

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Introduction: Skin damage due to overexposure to ultraviolet B (UV-B) radiation can lead to the development of cancers and reduce the skin's functionality as a vital protective barrier. Epidermal stem cells (ESCs) are pluripotent cells responsible for skin regeneration and healing. Upon exposure to UV-B radiation, ESCs produce excess amounts of reactive oxygen species (ROS) and inflammatory cytokines. However, the functional protection of ESCs is not fully explored. G-protein coupled G protein-coupled receptor 40 (Gpr40) is a free fatty acid receptor that is emerging as a potential treatment target for various diseases. Gpr40 has been found to be expressed in various cell types. Methods: ESCs were exposed to UV-B at the intensities of 25, 50, and 100 mJ/cm 2 for 24 h using TL 20 W/12 RS UV lamps. ESCs were treated with UV-B at 50 mJ/cm 2 in the presence or absence of 25 or 50 µM of the Gpr40 agonist GW9508 for 24 h. The gene expression of the Wnt1 pathway and proinflammatory cytokines were evaluated. To antagonize Gpr40 expression, ESCs were treated with 10 µM GW1100. Results: Our findings demonstrate that Gpr40 agonism can reduce the production of ROS as well as the expression of interleukins 1β and 8, two key proinflammatory cytokines. We demonstrate that agonism of Gpr40 can rescue the reduction in integrin β1 and Krt19 induced by UV-B exposure, thereby improving the capacities of ESCs to resist UV-B damage. Moreover, we show that the effects of Gpr40 agonism observed in our experiments are mediated through the Wnt/β-catenin canonical signaling pathway, as evidenced by the expression of Wnt1 and cyclin D1. Conclusion: Our findings present evidence of the role of Gpr40 agonism in mediating the protective capacities of ESCs against insult from UV-B radiation.

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Section: Discussionmentioning

confidence: 99%

<p>Agonism of Gpr40 Protects the Capacities of Epidermal Stem Cells (ESCs) Against Ultraviolet-B (UV-B)</p>

Sun

Li²,

et al. 2020

DDDT

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“…Likewise, Wu et al (2016) revealed that the induction of anthocyanin under UV-B radiation is regulated by the interaction between H 2 O 2 , NO and UVR8 in radish. Similarly, Cassia et al (2019) proposed that UV-B triggers the accumulation of ABA, which increases the production of H 2 O 2 and NO. In the process, the UV-B receptor UVR8 is activated.…”

Section: Ozone-induced Stress Triggers Nitric Oxide Signaling In Plantsmentioning

confidence: 99%

Nitric oxide: A core signaling molecule under elevated GHGs (CO2, CH4, N2O, O3)-mediated abiotic stress in plants

Kabange

Mun²,

Lee³

et al. 2022

Front. Plant Sci.

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Nitric oxide (NO), an ancient molecule with multiple roles in plants, has gained momentum and continues to govern plant biosciences-related research. NO, known to be involved in diverse physiological and biological processes, is a central molecule mediating cellular redox homeostasis under abiotic and biotic stresses. NO signaling interacts with various signaling networks to govern the adaptive response mechanism towards stress tolerance. Although diverging views question the role of plants in the current greenhouse gases (GHGs) budget, it is widely accepted that plants contribute, in one way or another, to the release of GHGs (carbon dioxide (CO2), methane (CH4), nitrous oxide (N2O) and ozone (O3)) to the atmosphere, with CH4 and N2O being the most abundant, and occur simultaneously. Studies support that elevated concentrations of GHGs trigger similar signaling pathways to that observed in commonly studied abiotic stresses. In the process, NO plays a forefront role, in which the nitrogen metabolism is tightly related. Regardless of their beneficial roles in plants at a certain level of accumulation, high concentrations of CO2, CH4, and N2O-mediating stress in plants exacerbate the production of reactive oxygen (ROS) and nitrogen (RNS) species. This review assesses and discusses the current knowledge of NO signaling and its interaction with other signaling pathways, here focusing on the reported calcium (Ca2+) and hormonal signaling, under elevated GHGs along with the associated mechanisms underlying GHGs-induced stress in plants.

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“…In parallel, NO levels increase in response to UV-B in plants ( Mackerness et al., 2001 ; Zhang et al., 2003 ) and it acts as an important factor in protecting plants against UV-B effects. It has been reported that when plants with a decrease of endogenous NO are exposed to UV-B radiation, damaged symptoms are enhanced ( Cassia et al., 2019 ). The perception of UV-B by UVR8 leads to an increase in these NO levels regulating the stomatal closure, protecting the microtubules organization, scavenging ROS, and upregulating HY5 ( Krasylenko et al., 2012 ; Tossi et al., 2014 ; Li et al., 2022 ).…”

Section: Uv Radiationmentioning

confidence: 99%

Functions of nitric oxide-mediated post-translational modifications under abiotic stress

et al. 2023

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Environmental conditions greatly impact plant growth and development. In the current context of both global climate change and land degradation, abiotic stresses usually lead to growth restriction limiting crop production. Plants have evolved to sense and respond to maximize adaptation and survival; therefore, understanding the mechanisms involved in the different converging signaling networks becomes critical for improving plant tolerance. In the last few years, several studies have shown the plant responses against drought and salinity, high and low temperatures, mechanical wounding, heavy metals, hypoxia, UV radiation, or ozone stresses. These threats lead the plant to coordinate a crosstalk among different pathways, highlighting the role of phytohormones and reactive oxygen and nitrogen species (RONS). In particular, plants sense these reactive species through post-translational modification (PTM) of macromolecules such as nucleic acids, proteins, and fatty acids, hence triggering antioxidant responses with molecular implications in the plant welfare. Here, this review compiles the state of the art about how plant systems sense and transduce this crosstalk through PTMs of biological molecules, highlighting the S-nitrosylation of protein targets. These molecular mechanisms finally impact at a physiological level facing the abiotic stressful traits that could lead to establishing molecular patterns underlying stress responses and adaptation strategies.

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The Role of Nitric Oxide in the Antioxidant Defense of Plants Exposed to UV‐B Radiation

Cited by 15 publications

References 101 publications

<p>Agonism of Gpr40 Protects the Capacities of Epidermal Stem Cells (ESCs) Against Ultraviolet-B (UV-B)</p>

<p>Agonism of Gpr40 Protects the Capacities of Epidermal Stem Cells (ESCs) Against Ultraviolet-B (UV-B)</p>

Nitric oxide: A core signaling molecule under elevated GHGs (CO2, CH4, N2O, O3)-mediated abiotic stress in plants

Functions of nitric oxide-mediated post-translational modifications under abiotic stress

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