The Role of Nicotinic Receptors on Ca2+ Signaling in Bovine Chromaffin Cells
Amparo Gil,
Virginia González-Vélez,
Luis Miguel Gutiérrez
et al.
Abstract:Chromaffin cells have been used as a physiological model to understand neurosecretion in mammals for many years. Nicotinic receptors located in the cells’ membrane are stimulated by acetylcholine, and they participate in the exocytosis of chromaffin granules, releasing catecholamines in response to stress. In this work, we discuss how the participation of nicotinic receptors and the localization of active zones in the borders of the cytoskeleton can generate local calcium signals leading to secretion. We use a… Show more
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