The role of nickel allergy in hand dermatitis and its impact on handling cupronickel currency coins. A comparative cohort study from Kuwait

Al-Mutairi, Nawaf; Almutawa, Fahad

doi:10.5114/ada.2017.69309

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…In some publications however an allergic reaction to a stainless steel bar or a positive patch test was more common in females [20]. It is also considered that polymorphisms in angiotensin converting enzyme (ACE), tumour necrosis factor (TNF), and N-acetyltransferase or filaggrin gene mutation may increase the chance of a pathological allergic reaction [16,[21][22][23].…”

Section: Mechanismmentioning

confidence: 99%

“…The advantage of titanium bars is not only the allergic reaction reduction, but also it is not contraindicated during magnetic resonance imaging. It is important to point out that allergy to titanium also exists, but is much more uncommon [13,16,[20][21][22]. Several scholars have reported cases of a suspected titanium allergy including cardiac pacemak-ers (with signs of pruritus, redness, and swelling of the skin overlying a titanium-containing pacemaker), failed total hip replacements and eczema upon titanium-based osteosynthesis [24].…”

Section: Mechanismmentioning

confidence: 99%

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Metal allergy after the Nuss procedure for pectus excavatum: a review

Gałązka¹,

Leis²,

Kroczek³

et al. 2020

pdia

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Minimally invasive repair of pectus excavatum (MIRPE) technique (the Nuss procedure) is a minimally-invasive method that is commonly used in the treatment of pectus excavatum. An allergic reaction to the metal alloy bar that is implanted in the thorax during the procedure is a reported complication. We briefly review current literature concerning epidemiology, mechanisms and research results of allergic reactions after Nuss bar implantation. This allergic reaction occurs in approximately 2.7% of patients and is caused by metals used in the medical implant. The most common symptoms include fever and skin lesions such as allergic dermatitis. Elevated levels of C-reactive protein is a frequent finding in laboratory tests. In order to minimize the risk of such complications, taking a detailed allergy-based medical history and conducting allergy tests, i.e. patch test are required. Allergic reactions can be managed with conservative treatment such as general or topical glucocorticosteroid therapy and antihistamine agents. Severe allergic reactions can be addressed by implant revision, replacement of the steel bar with a titanium substitute or removal of the stabilization at all. Although the risk of an allergic reaction to titanium is smaller it still exists, the titanium substitute is not routinely used due to its higher cost and lesser plasticity which has a negative impact on matching a stabilizing bar during the surgery. Surgeons treating pectus excavatum should remember about the possible allergic reactions after implantation of the metal bar and be familiar with methods of diagnosis and treatment of those complications.

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Section: Mechanismmentioning

confidence: 99%

Section: Mechanismmentioning

confidence: 99%

Metal allergy after the Nuss procedure for pectus excavatum: a review

Gałązka¹,

Leis²,

Kroczek³

et al. 2020

pdia

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Cobalt and nickel impair DNA metabolism by the oxidative stress independent pathway

et al. 2017

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The oxidative stress that evolves under cobalt and nickel exposure is thought to exert toxicity, though the exact routes of such metal poisoning remain ambiguous. We revisited the metal toxicity in Escherichia coli to show that cobalt and nickel exposure at levels as low as 0.5 and 1 mM, respectively, visibly inhibits growth. We also observed that acidic conditions aggravated, while alkaline conditions alleviated the metal toxicity. Besides, 1 mM manganese, which is non-cytotoxic, as judged by the growth of E. coli, synergistically elevated cobalt and nickel stress. However, the metal toxicity did not lead to oxidative stress in E. coli. On the other hand, we show that cobalt and nickel, but not manganese, reduced the rate of DNA replication to 50% within 2 hours. Interestingly, the metal ions promoted DNA double-strand breaks but did not induce SOS repair pathways, indicating that the metal ions could block SOS induction. To test this, we show that cobalt and nickel, but not manganese, suppressed the nalidixic acid-induced SOS response. Finally, using an in vitro assay system, we demonstrated that cobalt and nickel inhibit RecBCD function, which is essential for SOS induction. Therefore, our data indicate that cobalt and nickel affect DNA replication, damage DNA, and inhibit the SOS repair pathway to exert toxicity.

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A comprehensive study of nickel levels in everyday items in Brazil

Pavesi

Moreira

2020

Contact Dermatitis

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BackgroundNickel is a ubiquitous element used in many everyday items. In recent decades nickel has become a leading allergen, which has become a public health problem.ObjectiveTo evaluate frequently used nickel products in Brazil. We investigated if these objects release nickel that is capable of inducing sensitization or cause clinical manifestations in terms of allergic contact dermatitis (ACD).MethodsDimethylglyoxime (DMG) spot tests assessed nickel release from several common utensils used in everyday life in São Paulo and Rio de Janeiro, Brazil.ResultsWe tested 46 coins (two denominations) and 90 common utensils. Approximately 91.1% produced nickel‐positive results using the DMG spot test.ConclusionsThe DMG limit of detection was 1.67 ppm of nickel. We observed that many objects in our test series released nickel above the DMG test limit. This observation suggests that nickel‐sensitive individuals may be exposed to nickel, representing a public health issue.

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The role of nickel allergy in hand dermatitis and its impact on handling cupronickel currency coins. A comparative cohort study from Kuwait

Cited by 4 publications

References 35 publications

Metal allergy after the Nuss procedure for pectus excavatum: a review

Metal allergy after the Nuss procedure for pectus excavatum: a review

Cobalt and nickel impair DNA metabolism by the oxidative stress independent pathway

A comprehensive study of nickel levels in everyday items in Brazil

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